Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Prezista vs. Evotaz

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Prezista (darunavir) and Evotaz (atazanavir/cobicistat) are both oral antiretroviral medications used to treat HIV. They are both protease inhibitors, but there are several differences between them. Prezista is taken with a booster like ritonavir, while Evotaz already contains cobicistat as a booster. Prezista is available as a tablet or oral suspension, whereas Evotaz is only available as a tablet. Prezista can be used in children as young as 3 years old, while Evotaz is approved for those weighing at least 77 pounds. Prezista is safe during pregnancy, but Evotaz is not recommended because it may not work as well during pregnancy. Common side effects of Prezista include diarrhea, rash, and nausea, while Evotaz can cause jaundice and rash. Both medications interact with many other drugs, but Evotaz must be separated from heartburn medications.

  • Prezista (darunavir)
    Evotaz (atazanavir / cobicistat)
  • Prezista (darunavir)
    Evotaz (atazanavir / cobicistat)

  • Summary of Prezista vs. Evotaz

    Summary for HIV ARV
    Prescription only

    Prezista (darunavir) is an oral tablet or suspension that's used as part of an antiretroviral (ARV) regimen to treat human immunodeficiency virus (HIV) infections. It's often taken in combination with a "booster," like ritonavir (Norvir), to help Prezista (darunavir) work better against the virus. Rarely, this medication can cause a skin rash within the first month of treatment, but it typically goes away on its own. Lastly, let your provider know if you have a history of sulfa allergy since Prezista (darunavir) contains a "sulfa" component.

    Summary for Antiretroviral
    Prescription only

    Evotaz (atazanavir / cobicistat) is a combination medication that's taken as part of an antiretroviral (ARV) regimen to treat HIV (human immunodeficiency virus). It's approved for people with HIV who weigh at least 77 pounds. Evotaz (atazanavir / cobicistat) is a tablet that's taken once a day with food. It must be taken along with other HIV ARV medications. Evotaz (atazanavir / cobicistat) can cause side effects, including rash and jaundice (yellowing of the skin or eyes).

  • Indications of Prezista vs. Evotaz

    Indications for
    •Treatment of HIV infection in people aged 3 years and older
    Indications for
    •Treatment of HIV

  • Pros and Cons of Prezista vs. Evotaz

    Pros and Const for HIV ARV
    Pros
    •Taken once a day by mouth
    •Available as an oral suspension, so it's convenient if you have trouble swallowing pills
    •Safe to take during pregnancy
    Cons
    •Requires regular blood work and lab tests
    •Interacts with many medications
    •Must be used carefully in people with sulfa allergies
    Pros and Const for Antiretroviral
    Pros
    •Taken once a day
    •Combination tablet, so there are fewer pills to take
    •Same dose for adults and children who weigh at least 77 pounds
    •Can take if you have a sulfa allergy
    Cons
    •Need to take with food
    •Might cause jaundice (yellowing of skin or eyes)
    •Interacts with a lot of medications, such as certain other HIV medications, statins, and certain blood thinners
    •Must be separated from medications that treat heartburn and indigestion by a certain amount of time

  • Common Side Effects of Prezista vs. Evotaz

    Common Side Effects for
    •Diarrhea (9-14%)
    •Rash (6-7%)
    •Nausea (4-7%)
    •Headache (3-7%)
    •Stomach pain (6%)
    •Vomiting (2-5%)

    Side effects above were reported in adults taking this medication with ritonavir (Norvir). Side effects might differ in children.

    Common Side Effects for
    •Jaundice (yellowing of the skin or eyes; up to 6%)
    •Rash (5%)

  • Warnings of Prezista vs. Evotaz

    Common Side Effects for
    •Liver problems
    •Severe skin and allergic reactions
    •Changes in body fat
    •Overactive immune system
    •Bleeding
    •Interactions with other medications
    Common Side Effects for
    •Heart rhythm problems
    •Rash and other severe skin reactions
    •Kidney problems
    •Kidney stones or gallstones
    •Liver problems
    •High bilirubin levels
    •Interactions with other medications (including certain HIV ARVs)
    •Overactive immune system
    •High blood sugar
    •Changes in body fat
    •Risk of bleeding in people with hemophilia

  • Prices with our coupons for Prezista vs. Evotaz

    Learn more about Prezista
    Learn more about Evotaz

Compare other HIV Treatment drugs

Prezista vs AptivusPrezista vs CrixivanPrezista vs EvotazPrezista vs GenvoyaPrezista vs InvirasePrezista vs KaletraPrezista vs LexivaPrezista vs PrezcobixPrezista vs StribildPrezista vs TriumeqPrezista vs ViraceptAtripla vs GenvoyaAtripla vs StribildEpivir vs GenvoyaEvotaz vs GenvoyaEvotaz vs PrezcobixEvotaz vs StribildEvotaz vs TriumeqGenvoya vs CompleraGenvoya vs DescovyGenvoya vs EdurantGenvoya vs SustivaInvirase vs AptivusInvirase vs CrixivanLexiva vs CrixivanPrezcobix vs GenvoyaReyataz vs CrixivanTivicay vs GenvoyaViracept vs CrixivanZiagen vs Genvoya
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.