Key takeaways
Prezista (darunavir) and Evotaz (atazanavir/cobicistat) are both oral antiretroviral medications used to treat HIV. They are both protease inhibitors, but there are several differences between them. Prezista is taken with a booster like ritonavir, while Evotaz already contains cobicistat as a booster. Prezista is available as a tablet or oral suspension, whereas Evotaz is only available as a tablet. Prezista can be used in children as young as 3 years old, while Evotaz is approved for those weighing at least 77 pounds. Prezista is safe during pregnancy, but Evotaz is not recommended because it may not work as well during pregnancy. Common side effects of Prezista include diarrhea, rash, and nausea, while Evotaz can cause jaundice and rash. Both medications interact with many other drugs, but Evotaz must be separated from heartburn medications.
