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Compare Evotaz vs. Stribild

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Evotaz (atazanavir/cobicistat) and Stribild (elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate) are both medications used to treat HIV, but they have some key differences. Evotaz is a combination of two drugs: atazanavir, a protease inhibitor, and cobicistat, a booster. It must be taken with other HIV medications to form a complete treatment regimen. On the other hand, Stribild is a single-tablet regimen that includes four drugs: elvitegravir, an integrase inhibitor, emtricitabine and tenofovir, both nucleoside reverse transcriptase inhibitors (NRTIs), and cobicistat. This means you can take Stribild alone for HIV treatment. Both medications need to be taken with food, but Stribild is not recommended for people with kidney or liver problems, while Evotaz can be used with caution in these cases. Additionally, Stribild can cause bone problems and is not a good option for pregnant individuals, whereas Evotaz can cause jaundice and is also not recommended during pregnancy. Both medications interact with many other drugs, so it's important to discuss all your medications with your healthcare provider.

  • Evotaz (atazanavir / cobicistat)
    Stribild
  • Evotaz (atazanavir / cobicistat)
    Stribild

  • Summary of Evotaz vs. Stribild

    Summary for Antiretroviral
    Prescription only

    Evotaz (atazanavir / cobicistat) is a combination medication that's taken as part of an antiretroviral (ARV) regimen to treat HIV (human immunodeficiency virus). It's approved for people with HIV who weigh at least 77 pounds. Evotaz (atazanavir / cobicistat) is a tablet that's taken once a day with food. It must be taken along with other HIV ARV medications. Evotaz (atazanavir / cobicistat) can cause side effects, including rash and jaundice (yellowing of the skin or eyes).

    Summary for HIV ARV Combo
    Prescription only

    Stribild is a single-tablet-regimen containing 3 HIV antiretrovirals (ARVs), elvitegravir (Vitekta), emtricitabine (Emtriva), and tenofovir DF (Viread), and one booster medication, cobicistat (Tybost).

  • Indications of Evotaz vs. Stribild

    Indications for
    •Treatment of HIV
    Indications for
    •HIV treatment

  • Pros and Cons of Evotaz vs. Stribild

    Pros and Const for Antiretroviral
    Pros
    •Taken once a day
    •Combination tablet, so there are fewer pills to take
    •Same dose for adults and children who weigh at least 77 pounds
    •Can take if you have a sulfa allergy
    Cons
    •Need to take with food
    •Might cause jaundice (yellowing of skin or eyes)
    •Interacts with a lot of medications, such as certain other HIV medications, statins, and certain blood thinners
    •Must be separated from medications that treat heartburn and indigestion by a certain amount of time
    Pros and Const for HIV ARV Combo
    Pros
    •1 tablet once a day is a full HIV regimen
    •Contains tenofovir, which is also a first-choice treatment option for hepatitis B
    •One of the few single-tablet-regimens that contains an integrase inhibitor (a preferred HIV ARV subclass)
    •In clinical trials, caused less abnormal dreams than Atripla
    •Gilead copay card available for people with commercial health plans (not for use with Medicaid and Medicare plans)
    Cons
    •Must be taken with food
    •Dose can't be adjusted, so it's not recommended for people with kidney or liver problems
    •Can cause kidney and bone problems
    •Interacts with a lot of medications
    •Not a good option for people who are pregnant, or plan to become pregnant

  • Common Side Effects of Evotaz vs. Stribild

    Common Side Effects for
    •Jaundice (yellowing of the skin or eyes; up to 6%)
    •Rash (5%)
    Common Side Effects for
    •Nausea (16%)
    •Diarrhea (12%)
    •Abnormal, strange dreams (9%)
    •Headache (7%)

  • Warnings of Evotaz vs. Stribild

    Common Side Effects for
    •Heart rhythm problems
    •Rash and other severe skin reactions
    •Kidney problems
    •Kidney stones or gallstones
    •Liver problems
    •High bilirubin levels
    •Interactions with other medications (including certain HIV ARVs)
    •Overactive immune system
    •High blood sugar
    •Changes in body fat
    •Risk of bleeding in people with hemophilia
    Common Side Effects for
    •WORSENING OF HEPATITIS B
    •CHANGES IN KIDNEY FUNCTION
    •LIVER PROBLEMS
    •DRUG INTERACTIONS
    •BONE PROBLEMS
    •IMMUNE RECONSTITUTION SYNDROME

  • Prices with our coupons for Evotaz vs. Stribild

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