Key takeaways
Prezcobix (darunavir/cobicistat) and Reyataz (atazanavir) are both antiretroviral medications used to treat HIV infections, but they have some key differences. Prezcobix is a combination of two medications: darunavir, a protease inhibitor, and cobicistat, a booster that helps darunavir work better. Reyataz, on the other hand, is usually taken with a separate booster like ritonavir. Prezcobix is taken as a single tablet once daily, while Reyataz can be taken as a tablet or powder, also once daily. Prezcobix is not recommended during pregnancy, whereas Reyataz can be used during pregnancy without increasing the risk of birth defects. Additionally, Prezcobix must be taken with food and is not safe for people with sulfa allergies, while Reyataz also needs to be taken with food and is not suitable for those with serious kidney problems. Both medications can cause high blood sugar and changes in body fat, but Reyataz has a higher risk of causing jaundice.
