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Compare Prezcobix vs. Reyataz

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Prezcobix (darunavir/cobicistat) and Reyataz (atazanavir) are both antiretroviral medications used to treat HIV infections, but they have some key differences. Prezcobix is a combination of two medications: darunavir, a protease inhibitor, and cobicistat, a booster that helps darunavir work better. Reyataz, on the other hand, is usually taken with a separate booster like ritonavir. Prezcobix is taken as a single tablet once daily, while Reyataz can be taken as a tablet or powder, also once daily. Prezcobix is not recommended during pregnancy, whereas Reyataz can be used during pregnancy without increasing the risk of birth defects. Additionally, Prezcobix must be taken with food and is not safe for people with sulfa allergies, while Reyataz also needs to be taken with food and is not suitable for those with serious kidney problems. Both medications can cause high blood sugar and changes in body fat, but Reyataz has a higher risk of causing jaundice.

  • Prezcobix (darunavir / cobicistat)
    Atazanavir (Reyataz)
  • Prezcobix (darunavir / cobicistat)
    Atazanavir (Reyataz)

  • Summary of Prezcobix vs. Reyataz

    Summary for HIV ARV
    Prescription only

    Prezcobix (darunavir / cobicistat), also known as DRV/COBI, is an antiretroviral (ARV) medication that treats HIV (human immunodeficiency virus) infections in people who weigh at least 88 pounds. It's typically taken with other HIV ARVs to make up a complete treatment regimen. Prezcobix (darunavir / cobicistat) is an oral tablet that's taken once daily. It's important to take the medication every day to prevent HIV drug resistance (when HIV medications no longer work). A side effect of Prezcobix (darunavir / cobicistat) is a skin rash that appears within the first month of treatment, but it typically goes away on its own.

    Summary for HIV ARV
    Prescription only

    Atazanavir (Reyataz) is an oral tablet or powder that's used as part of an antiretroviral (ARV) regimen to treat human immunodeficiency virus (HIV) infections. It's often taken in combination with a "booster," like ritonavir (Norvir), to help atazanavir (Reyataz) work better against the virus. Some common side effects of this medication include nausea, vomiting, and headache. Rarely, this medication can also cause jaundice, which is a health condition that causes the skin or whites of the eyes to turn yellow.

  • Indications of Prezcobix vs. Reyataz

    Indications for
    •Treatment of HIV infection in adults and children weighing at least 88 pounds
    Indications for
    •Treatment of HIV infection

  • Pros and Cons of Prezcobix vs. Reyataz

    Pros and Const for HIV ARV
    Pros
    •Taken once a day by mouth
    •Combines two medications into one pill for convenience
    •Safe to use in adults and children weighing at least 88 pounds
    Cons
    •Interacts with many medications, such as certain statins and blood thinners
    •Must be used carefully in people with sulfa allergies
    •Not recommended during pregnancy (being pregnant can cause the medication to work less well)
    Pros and Const for HIV ARV
    Pros
    •Powder form can be mixed with soft food or liquid, such as applesauce or milk, so convenient for people with difficulty swallowing pills
    •Available as a lower-cost generic medication
    •Can be used in young children 3 months and older who weigh over 5 kg (powder form)
    •Only taken once a day
    Cons
    •Interacts with a lot of medications
    •Requires regular blood work and lab tests
    •Not safe for use for people with serious kidney problems
    •Needs to be taken with food

  • Common Side Effects of Prezcobix vs. Reyataz

    Common Side Effects for

    Side effects below were reported in at least 5% of adults taking Prezista (darunavir) with ritonavir (Norvir) during clinical studies.

    •Diarrhea
    •Nausea
    •Stomach pain
    •Vomiting
    •Headache
    •Rash

    Side effects below were reported in at least 5% of adults taking Tybost (cobicistat) with other HIV medications in clinical studies.

    •Jaundice
    •Rash
    Common Side Effects for
    •Higher liver enzyme levels (44-49%)
    •Higher cholesterol levels (up to 25%)
    •Nausea (3-14%)
    •Yellowing of the skin or whites of the eyes (7-9%)
    •Headache (1-6%)
    •Vomiting (3-4%)
    •Belly pain (4%)
    •Nerve pain (4%)
    •Rash (3-7%)
    •Diarrhea (1-3%)

    Please note: The side effects above were reported in adults taking this medication with other HIV ARVs. Side effects might differ in children.

  • Warnings of Prezcobix vs. Reyataz

    Common Side Effects for
    •Liver problems
    •Severe skin and allergic reactions
    •Changes to blood test results for kidney function
    •Kidney problems when used with tenofovir disoproxil fumarate (TDF)
    •High blood sugar
    •Changes in body fat
    •Overactive immune system
    •Risk of bleeding in people with hemophilia
    •Interactions with other medications
    Common Side Effects for
    •Heart rhythm problems (PR prolongation)
    •Severe skin and allergic reactions
    •Liver problems
    •Kidney problems
    •Risk of kidney stones or gallstones
    •High blood sugar
    •Overactive immune system
    •Changes in body fat
    •Risk of bleeding
    •Interactions with other medications

  • Prices with our coupons for Prezcobix vs. Reyataz

    Learn more about Prezcobix
    Learn more about Atazanavir

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