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Compare Reyataz vs. Crixivan

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Atazanavir (Reyataz) and indinavir (Crixivan) are both medications used to treat HIV infections when taken with other HIV antiretrovirals. They both belong to the protease inhibitor class of antiretroviral (ARV) medications. However, there are several differences between them. Atazanavir (Reyataz) is still available and is taken orally, either as a tablet or powder, while indinavir (Crixivan) has been discontinued in the U.S. due to business reasons and the availability of newer treatments. Atazanavir (Reyataz) is typically taken once daily with food and often requires a "booster" like ritonavir to enhance its effectiveness. In contrast, indinavir (Crixivan) was known for its side effects and interactions, which contributed to its decline in use. Atazanavir (Reyataz) can cause side effects like nausea, headache, and jaundice, and it interacts with many medications, requiring careful management.

  • Atazanavir (Reyataz)
    Crixivan (indinavir)
  • Atazanavir (Reyataz)
    Crixivan (indinavir)

  • Summary of Reyataz vs. Crixivan

    Summary for HIV ARV
    Prescription only

    Atazanavir (Reyataz) is an oral tablet or powder that's used as part of an antiretroviral (ARV) regimen to treat human immunodeficiency virus (HIV) infections. It's often taken in combination with a "booster," like ritonavir (Norvir), to help atazanavir (Reyataz) work better against the virus. Some common side effects of this medication include nausea, vomiting, and headache. Rarely, this medication can also cause jaundice, which is a health condition that causes the skin or whites of the eyes to turn yellow.

    Summary for HIV ARV

    Crixivan (indinavir) was one of the first HIV antiretroviral (ARV) medications approved by the FDA. Due to side effects and medication interactions, it has not been a first choice treatment option for many years and has been discontinued in the U.S.

  • Indications of Reyataz vs. Crixivan

    Indications for
    •Treatment of HIV infection
    Indications for

  • Pros and Cons of Reyataz vs. Crixivan

    Pros and Const for HIV ARV
    Pros
    •Powder form can be mixed with soft food or liquid, such as applesauce or milk, so convenient for people with difficulty swallowing pills
    •Available as a lower-cost generic medication
    •Can be used in young children 3 months and older who weigh over 5 kg (powder form)
    •Only taken once a day
    Cons
    •Interacts with a lot of medications
    •Requires regular blood work and lab tests
    •Not safe for use for people with serious kidney problems
    •Needs to be taken with food
    Pros and Const for HIV ARV
    Pros
    Cons

  • Common Side Effects of Reyataz vs. Crixivan

    Common Side Effects for
    •Higher liver enzyme levels (44-49%)
    •Higher cholesterol levels (up to 25%)
    •Nausea (3-14%)
    •Yellowing of the skin or whites of the eyes (7-9%)
    •Headache (1-6%)
    •Vomiting (3-4%)
    •Belly pain (4%)
    •Nerve pain (4%)
    •Rash (3-7%)
    •Diarrhea (1-3%)

    Please note: The side effects above were reported in adults taking this medication with other HIV ARVs. Side effects might differ in children.

    Common Side Effects for

  • Warnings of Reyataz vs. Crixivan

    Common Side Effects for
    •Heart rhythm problems (PR prolongation)
    •Severe skin and allergic reactions
    •Liver problems
    •Kidney problems
    •Risk of kidney stones or gallstones
    •High blood sugar
    •Overactive immune system
    •Changes in body fat
    •Risk of bleeding
    •Interactions with other medications
    Common Side Effects for

  • Prices with our coupons for Reyataz vs. Crixivan

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    Learn more about Crixivan

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