Key takeaways
Atazanavir (Reyataz) and tipranavir (Aptivus) are both antiretroviral (ARV) medications used to treat HIV infections when taken with other HIV antiretrovirals. They belong to the same class of medications called protease inhibitors, which work by blocking a protein that the HIV virus needs to make copies of itself. However, there are several differences between the two. Atazanavir (Reyataz) is available as an oral tablet or powder and is typically taken once daily, often with a booster like ritonavir (Norvir). It is available as a generic medication and can be used in children as young as 3 months old. Common side effects include nausea, headache, and jaundice. On the other hand, tipranavir (Aptivus) is usually taken as 500 mg with ritonavir 200 mg twice daily, requiring multiple capsules per day. It is available as an oral solution for those who have trouble swallowing capsules. Tipranavir (Aptivus) is not recommended for people with sulfa allergies or moderate to severe liver problems. Common side effects include diarrhea, nausea, and fatigue. Both medications interact with many other drugs, but tipranavir (Aptivus) is known for more severe interactions, including with birth control pills.
