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Compare Triumeq vs. Juluca

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Triumeq (abacavir/dolutegravir/lamivudine) and Juluca (dolutegravir/rilpivirine) are both HIV antiretroviral (ARV) medications, but they have some key differences. Triumeq is a three-drug combination that includes abacavir, dolutegravir, and lamivudine, and is used for treating HIV in people who weigh at least 13 pounds. It requires a genetic test before starting to check for a risk of serious allergic reactions. Juluca, on the other hand, is a two-drug combination of dolutegravir and rilpivirine, and is only for people who are already well-controlled on their current HIV regimen and want to switch. Unlike Triumeq, Juluca must be taken with a meal and cannot be used with proton pump inhibitors like omeprazole. Both medications can cause serious allergic reactions and liver problems, but Juluca also has a risk of mood changes and depression. Triumeq is available as both a regular tablet and dissolvable tablet for children, while Juluca is only available as a regular tablet.

  • Triumeq
    Juluca (dolutegravir / rilpivirine)
  • Triumeq
    Juluca (dolutegravir / rilpivirine)

  • Summary of Triumeq vs. Juluca

    Summary for HIV ARV
    Prescription only

    Triumeq is a single-tablet regimen used to treat human immunodeficiency virus (HIV) infections. It contains 3 antiretrovirals (ARVs): abacavir, dolutegravir, and lamivudine. Triumeq is available as either a tablet or a dissolvable tablet for oral suspension (Triumeq PD), but the two are not the same. Before starting treatment, your provider will require you to get a genetic test to see if you're at risk for developing a serious allergic reaction to this medication.

    Summary for HIV ARV combo
    Prescription only

    Juluca (dolutegravir / rilpivirine) is an HIV antiretroviral (ARV) tablet that contains two medications. It's not meant for people who have never taken HIV ARVs. Still, it's a good option for people who are well controlled on their current HIV regimen and want to switch to different regimen.

  • Indications of Triumeq vs. Juluca

    Indications for
    •Treatment of HIV infection (in people who weigh at least 22 pounds)
    Indications for
    •HIV treatment for people who are well controlled on an HIV ARV regimen already and want to switch regimens

  • Pros and Cons of Triumeq vs. Juluca

    Pros and Const for HIV ARV
    Pros
    •Only taken once a day for complete HIV treatment
    •Combines three medications into one pill for convenience
    •Can be taken with or without food
    •Available for adults and children at or over 22 lbs
    Cons
    •Dose can't be adjusted so it's not recommended for people with kidney or liver problems
    •Not safe to use in severe liver problems
    •Requires a genetic test before starting
    •Interacts with a lot of medications such as St. John’s wort and oxcarbazepine (Trileptal)
    Pros and Const for HIV ARV combo
    Pros
    •Convenient; one tablet once a day
    •Two medications is a full HIV regimen; less risk for side effects
    •No dose adjustments needed for people with mild kidney or liver problems
    Cons
    •Must be taken with food
    •Not meant for people first starting HIV ARVs
    •Can interact with a lot of medications, including over-the-counter (OTC) heartburn products

  • Common Side Effects of Triumeq vs. Juluca

    Common Side Effects for
    •Higher lipase levels (suggesting irritated pancreas) (up to 11%)
    •Higher blood sugar levels (up to 9%)
    •Higher creatine kinase levels in the blood (suggesting muscle damage) (up to 7%)
    •Higher fat levels in the blood (up to 6%)
    •Higher white blood cell count (up to 4%)
    •Abnormal liver labs (up to 3%)
    •Trouble sleeping (3%)
    •Headache (2%)
    •Feeling tired (2%)

    Please note: The side effects listed above are from clinical trials with Tivicay (dolutegravir) and Epzicom (abacavir / lamivudine), which are all active ingredients in Triumeq and Triumeq PD

    Common Side Effects for
    •Diarrhea (2%)
    •Headache (2%)

  • Warnings of Triumeq vs. Juluca

    Common Side Effects for
    •Serious allergic reaction
    •Worsening of hepatitis B virus (HBV) infection
    •Liver problems
    •Overactive immune system
    •Interaction with other medications
    Common Side Effects for
    •Severe rash and allergic reactions
    •Liver toxicity
    •Birth defects
    •Depression and changes in mood
    •Serious interactions with other medications

  • Prices with our coupons for Triumeq vs. Juluca

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