Key takeaways
Abacavir (Ziagen) and Trizivir (abacavir/lamivudine/zidovudine) are both medications used to treat HIV. They belong to the same drug class, nucleoside reverse transcriptase inhibitors (NRTIs), which work by stopping the HIV virus from making copies of itself. However, there are several differences between the two. Abacavir (Ziagen) is a single medication that can be taken as a tablet or oral solution, while Trizivir is a combination of three medications in one tablet. Abacavir (Ziagen) is typically taken once or twice daily, whereas Trizivir is taken twice daily. Both medications require a genetic test called HLA-B 5701 to prevent severe allergic reactions. Trizivir is not a full HIV regimen on its own and must be taken with at least one other HIV medication, while abacavir (Ziagen) is often used in combination with other HIV medications. Common side effects of abacavir (Ziagen) include headache, nausea, and fatigue, while Trizivir can cause nausea, vomiting, and headaches more frequently. Trizivir also has additional risks, such as blood and muscle problems, which are not associated with abacavir (Ziagen) alone. Both medications are available as generics, making them more affordable options.
