Key takeaways
Stribild (elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate) and Edurant (rilpivirine) are both medications used to treat HIV. However, they belong to different classes of antiretrovirals. Stribild is a combination medication that includes an integrase inhibitor and two nucleoside reverse transcriptase inhibitors (NRTIs), while Edurant is a non-nucleoside reverse transcriptase inhibitor (NNRTI). Both medications are taken once daily with food, but Edurant must be combined with other HIV medications. Stribild is not recommended for people with kidney or liver problems, while Edurant can be used in those with mild-to-moderate kidney and liver problems. Stribild can cause nausea and diarrhea and should not be taken within 2 hours of antacids. Edurant can cause depression and liver problems and should not be taken with certain heartburn medications like omeprazole. Additionally, Stribild is not recommended during pregnancy, while Edurant is considered safe for use during pregnancy.
