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Compare Odefsey vs. Edurant

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Odefsey (emtricitabine/rilpivirine/tenofovir alafenamide) and Edurant (rilpivirine) are both medications used to treat HIV, but they have some key differences. Odefsey is a combination of three antiretrovirals, including rilpivirine, and is taken as a single tablet once a day with a meal. It is designed to be a complete HIV treatment regimen on its own. In contrast, Edurant contains only rilpivirine and must be taken with other antiretroviral medications. Edurant is also used for short-term treatment before starting Cabenuva injections. Odefsey is noted for being safer for your kidneys and bones compared to older treatments, while Edurant is highlighted for its convenience and safety in people with mild-to-moderate kidney and liver problems. Both medications must be taken with a meal and have similar side effects, such as depression and liver issues. However, Odefsey has additional risks like bone density loss and kidney problems, which are not mentioned for Edurant.

  • Odefsey
    Edurant (rilpivirine)
  • Odefsey
    Edurant (rilpivirine)

  • Summary of Odefsey vs. Edurant

    Summary for HIV ARV Combo
    Prescription only

    Odefsey is a single-tablet-regimen containing 3 HIV antiretrovirals (ARVs), rilpivirine (Edurant), emtricitabine (Emtriva), and tenofovir AF (Vemlidy). It's similar to Complera, but contains a newer version of tenofovir which causes less harmful effects on your kidneys and bones.

    Summary for HIV ARV
    Prescription only

    Edurant (rilpivirine) is a once-daily antiretroviral medication that's taken by mouth and is used to treat human immunodeficiency virus (HIV) infection. It's approved for use in adults and children. Edurant (rilpivirine) is taken with other antiretroviral medications when it's used for certain people who've never had HIV treatment before. Edurant (rilpivirine) can also be used for a short period of time before starting Cabenuva (cabotegravir / rilpivirine). Side effects of Edurant (rilpivirine) can include depression, headache, and trouble sleeping.

  • Indications of Odefsey vs. Edurant

    Indications for
    •HIV treatment
    Indications for
    •Treatment of HIV-1 infection in people 2 years and older, weighing at least 30 pounds, with an HIV viral load of less than 100,000 copies/mL and who haven't taken HIV medications before
    •Short-term treatment of HIV-1 infection in certain people ages 12 years and older, weighing at least 77 pounds, who are planning to start or planning to miss a dose of Cabenuva (cabotegravir / rilpivirine)

  • Pros and Cons of Odefsey vs. Edurant

    Pros and Const for HIV ARV Combo
    Pros
    •1 tablet once a day is a full HIV regimen
    •Safer for your kidneys and bones when compared to Complera
    •Can be used in pregnancy at the same dose
    •Contains tenofovir, which is also a first-choice treatment option for hepatitis B
    •Not too many side effects
    Cons
    •Must be taken with a light meal
    •Dose can't be adjusted
    •Can't be used if the amount of virus (viral load) is too high
    •There are many medication interactions and it can't be taken with some medications used to treat tuberculosis, seizures, and stomach acid.
    •Not a first-choice treatment option for people new to HIV medications
    Pros and Const for HIV ARV
    Pros
    •Taken by mouth once a day, so it's convenient for people with a busy schedule
    •Can use in people with mild-to-moderate kidney and liver problems
    •Safe to use during pregnancy
    Cons
    •Can cause some allergic skin reactions
    •Must take with a meal
    •Only available as a brand-name medication

  • Common Side Effects of Odefsey vs. Edurant

    Common Side Effects for
    •Headache (2%)
    •Sleep problems (2%)
    Common Side Effects for
    •Higher liver function tests (up to 18%)
    •Higher cholesterol levels (up to 17%)
    •Higher creatinine levels (up to 6%)
    •Feeling depressed (5%)
    •Headache (3%)
    •Trouble sleeping (3%)
    •Rash (3%)

  • Warnings of Odefsey vs. Edurant

    Common Side Effects for
    •WORSENING OF HEPATITIS B
    •LIVER PROBLEMS AND TOXICITY
    •DEPRESSION AND CHANGES IN MOOD
    •KIDNEY PROBLEMS
    •BONE PROBLEMS
    •IMMUNE RECONSTITUTION SYNDROME
    Common Side Effects for
    •Severe skin reactions and allergic reactions
    •Liver problems
    •Depression and suicidal thoughts
    •Overactive immune system
    •Interaction with other medications

  • Prices with our coupons for Odefsey vs. Edurant

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