Key takeaways
Dovato (dolutegravir/lamivudine) and Atripla (efavirenz/emtricitabine/tenofovir disoproxil fumarate) are both used to treat HIV, but they have some key differences. Dovato combines two antiretrovirals (ARVs) into one pill, while Atripla combines three ARVs. Dovato is a first-choice treatment option and is taken once daily, with or without food. In contrast, Atripla is no longer a first-choice treatment due to its side effects and must be taken on an empty stomach, preferably at bedtime. Dovato can cause weight gain, while Atripla is not associated with weight gain but can lead to kidney and bone problems. Dovato and Atripla should be avoided by those with liver and kidney problems. Both medications can cause serious side effects, including liver problems and immune reconstitution syndrome, but Atripla also has notable mental health and central nervous system effects.
