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Compare Dovato vs. Juluca

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Dovato (dolutegravir/lamivudine) and Juluca (dolutegravir/rilpivirine) are both HIV treatments, but they have some key differences. Dovato is used as a first-choice treatment for adults starting HIV medications, while Juluca is meant for people who are already well-controlled on their current HIV regimen and want to switch. Dovato combines an integrase inhibitor (dolutegravir) and a nucleoside reverse transcriptase inhibitor (lamivudine), whereas Juluca combines the same integrase inhibitor (dolutegravir) with a non-nucleoside reverse transcriptase inhibitor (rilpivirine). Dovato can be taken with or without food, but Juluca must be taken with a meal. Additionally, Dovato is not recommended for people with severe kidney or liver problems, while Juluca does not require dose adjustments for mild kidney or liver issues. Both medications can interact with other drugs, but Juluca specifically cannot be taken with proton pump inhibitors like omeprazole.

  • Dovato (dolutegravir / lamivudine)
    Juluca (dolutegravir / rilpivirine)
  • Dovato (dolutegravir / lamivudine)
    Juluca (dolutegravir / rilpivirine)

  • Summary of Dovato vs. Juluca

    Summary for HIV ARV
    Prescription only

    Dovato (dolutegravir / lamivudine) is used to treat human immunodeficiency virus (HIV) infections. It's considered a complete HIV treatment regimen with only two antiretroviral (ARV) medications: dolutegravir and lamivudine. One of the benefits of Dovato (dolutegravir / lamivudine) is that it combines two medications into a single tablet so it's convenient to take. Possible side effects of Dovato (dolutegravir / lamivudine) can include headache and weight gain, but they aren't very common with this medication.

    Summary for HIV ARV combo
    Prescription only

    Juluca (dolutegravir / rilpivirine) is an HIV antiretroviral (ARV) tablet that contains two medications. It's not meant for people who have never taken HIV ARVs. Still, it's a good option for people who are well controlled on their current HIV regimen and want to switch to different regimen.

  • Indications of Dovato vs. Juluca

    Indications for
    •Treatment of HIV infection in adults
    Indications for
    •HIV treatment for people who are well controlled on an HIV ARV regimen already and want to switch regimens

  • Pros and Cons of Dovato vs. Juluca

    Pros and Const for HIV ARV
    Pros
    •First-choice treatment option for most adults starting HIV medications
    •Only contains two ARVs and is considered a complete HIV treatment regimen, which is less medications than other complete regimens
    •Combines two medications into one pill for convenience
    •Only taken once a day
    •Can take with or without food
    Cons
    •Interacts with a lot of medications, such as anti-seizure medications (e.g., oxcarbazepine (Trileptal)), metformin, and antacids
    •Can't take with dofetilide (Tikosyn) because of risk of serious side effects
    •Not approved for use in children
    •Not recommended for use if you have severe kidney or liver problems
    •Shouldn't use if you have both HIV and hepatitis B (HBV)
    Pros and Const for HIV ARV combo
    Pros
    •Convenient; one tablet once a day
    •Two medications is a full HIV regimen; less risk for side effects
    •No dose adjustments needed for people with mild kidney or liver problems
    Cons
    •Must be taken with food
    •Not meant for people first starting HIV ARVs
    •Can interact with a lot of medications, including over-the-counter (OTC) heartburn products

  • Common Side Effects of Dovato vs. Juluca

    Common Side Effects for
    •Higher blood sugar levels (up to 11%)
    •Lower phosphate levels (up to 11%)
    •Higher creatine kinase levels in the blood (up to 8%)
    •Higher lipase levels (up to 7%)
    •Abnormal liver labs (up to 5%)
    •Headache (3%)
    •Weight gain (3%)
    •Nausea (2%)
    •Diarrhea (2%)
    •Trouble sleeping (2%)
    •Feeling tired (2%)
    •Anxiety (2%)
    Common Side Effects for
    •Diarrhea (2%)
    •Headache (2%)

  • Warnings of Dovato vs. Juluca

    Common Side Effects for
    •Worsening of hepatitis B infection if you have HIV and hepatitis B
    •Allergic reaction
    •Liver problems and lactic acidosis
    •Overactive immune system
    •Interaction with other medications
    •Harm to unborn baby
    Common Side Effects for
    •Severe rash and allergic reactions
    •Liver toxicity
    •Birth defects
    •Depression and changes in mood
    •Serious interactions with other medications

  • Prices with our coupons for Dovato vs. Juluca

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