Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Odefsey vs. Complera

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Odefsey (emtricitabine/rilpivirine/tenofovir alafenamide) and Complera (emtricitabine/rilpivirine/tenofovir disoproxil fumarate) are both single-tablet regimens used to treat HIV. The main difference between the two is the form of tenofovir they contain. Odefsey has tenofovir alafenamide, which is newer and causes fewer harmful effects on your kidneys and bones compared to the tenofovir disoproxil fumarate in Complera. Both medications need to be taken with a meal at least 400 calories. Complera is no longer a first-choice treatment due to the availability of newer medications with fewer side effects, whereas Odefsey is considered safer for long-term use. Both medications have similar side effects, such as headaches and sleep problems, but Odefsey is noted to cause fewer abnormal dreams. Additionally, Complera has been used more often in pregnant individuals, although both can be taken during pregnancy.

  • Odefsey
    Complera
  • Odefsey
    Complera

  • Summary of Odefsey vs. Complera

    Summary for HIV ARV Combo
    Prescription only

    Odefsey is a single-tablet-regimen containing 3 HIV antiretrovirals (ARVs), rilpivirine (Edurant), emtricitabine (Emtriva), and tenofovir AF (Vemlidy). It's similar to Complera, but contains a newer version of tenofovir which causes less harmful effects on your kidneys and bones.

    Summary for HIV ARV Combo
    Prescription only

    Complera is a single-tablet regimen containing 3 HIV antiretrovirals (ARVs), rilpivirine (Edurant), emtricitabine (Emtriva), and tenofovir disoproxil fumarate (Viread). It's no longer a first-choice treatment option due to newer agents with fewer side effects.

  • Indications of Odefsey vs. Complera

    Indications for
    •HIV treatment
    Indications for
    •HIV treatment

  • Pros and Cons of Odefsey vs. Complera

    Pros and Const for HIV ARV Combo
    Pros
    •1 tablet once a day is a full HIV regimen
    •Safer for your kidneys and bones when compared to Complera
    •Can be used in pregnancy at the same dose
    •Contains tenofovir, which is also a first-choice treatment option for hepatitis B
    •Not too many side effects
    Cons
    •Must be taken with a light meal
    •Dose can't be adjusted
    •Can't be used if the amount of virus (viral load) is too high
    •There are many medication interactions and it can't be taken with some medications used to treat tuberculosis, seizures, and stomach acid.
    •Not a first-choice treatment option for people new to HIV medications
    Pros and Const for HIV ARV Combo
    Pros
    •1 tablet once a day is a full HIV regimen
    •Can be used in pregnancy at the same dose
    •Contains tenofovir, which is also a first-choice treatment option for hepatitis B
    •Causes less abnormal dreams when compared to a similar medication Atripla
    •Not associated with weight gain
    Cons
    •Must be taken with food
    •Not recommended for people with kidney problems since the dose can't be adjusted
    •Can't be used if the amount of virus (viral load) is too high
    •There are many medication interactions and it can't be taken with some medications used to treat tuberculosis, seizures, and stomach acid.
    •Can lead to kidney and bone problems

  • Common Side Effects of Odefsey vs. Complera

    Common Side Effects for
    •Headache (2%)
    •Sleep problems (2%)
    Common Side Effects for
    •Change in mood, depression (2%)
    •Headache (2%)
    •Trouble sleeping, insomnia (2%)

  • Warnings of Odefsey vs. Complera

    Common Side Effects for
    •WORSENING OF HEPATITIS B
    •LIVER PROBLEMS AND TOXICITY
    •DEPRESSION AND CHANGES IN MOOD
    •KIDNEY PROBLEMS
    •BONE PROBLEMS
    •IMMUNE RECONSTITUTION SYNDROME
    Common Side Effects for
    •WORSENING OF HEPATITIS B
    •LIVER PROBLEMS AND TOXICITY
    •DEPRESSION AND CHANGES IN MOOD
    •KIDNEY PROBLEMS
    •BONE PROBLEMS
    •IMMUNE RECONSTITUTION SYNDROME

  • Prices with our coupons for Odefsey vs. Complera

    Learn more about Odefsey
    Learn more about Complera

Compare other HIV Treatment drugs

Dovato vs OdefseyOdefsey vs AtriplaOdefsey vs CompleraOdefsey vs DescovyOdefsey vs EdurantOdefsey vs TruvadaTriumeq vs OdefseyViread vs OdefseyAtripla vs TruvadaDovato vs TruvadaEmtriva vs CompleraEpzicom vs TruvadaGenvoya vs CompleraGenvoya vs EdurantIntelence vs EdurantStribild vs CompleraStribild vs EdurantSustiva vs EdurantTriumeq vs CompleraTriumeq vs TruvadaTruvada vs DescovyTruvada vs EdurantTruvada vs EmtrivaTruvada vs EpivirTruvada vs SustivaTruvada vs VidexTruvada vs VireadTruvada vs ZiagenViramune vs EdurantViread vs Complera
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.