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Emtriva vs. Descovy

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Emtricitabine (Emtriva) and Descovy (emtricitabine/tenofovir alafenamide) are both used to treat and prevent HIV, but they have some key differences. Emtricitabine (Emtriva) is a single medication, while Descovy is a combination of two antiretrovirals (ARVs). Both medications must be combined with other HIV ARVs for effective treatment of HIV. However, Descovy is a complete regimen for HIV pre-exposure prophylaxis (PrEP). Descovy is preferred for PrEP but is not effective for females at risk of HIV through receptive vaginal sex. Emtricitabine (Emtriva) is available as both a capsule and an oral solution, whereas Descovy is only available as a tablet. Both medications require regular lab tests to monitor their effectiveness and potential side effects, but Descovy is noted to be safer for the kidneys and bones compared to another similar medication, Truvada. Additionally, both medications can worsen hepatitis B if stopped suddenly, so it's important to follow your healthcare provider's instructions closely.

Emtricitabine

(Emtriva)

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Descovy

(emtricitabine / tenofovir alafenamide)

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Summary for Emtriva

Prescription only

Emtricitabine (Emtriva) is a first choice HIV antiretroviral (ARV) used in combination with other HIV ARVs for the treatment and prevention of HIV. It is one of the most common HIV ARVs used around the world.

Indications for Emtriva

  • HIV treatment

Pros and Cons for Emtriva

Pros

  • Very effective against HIV, with few side effects
  • Taken only once a day with or without food
  • Available in many combination tablets with other HIV ARVs
  • Available as a capsule and oral solution
  • Can be used in pregnancy and in children right after they are born

Cons

  • Dose must be adjusted if you have kidney problems
  • Must be used in combination with other HIV ARVs
  • The oral solution is absorbed less than the capsule, so the dose is higher
  • Some people with hepatitis B virus (HBV) have worsening of the liver after stopping emtricitabine (Emtriva)
  • Requires regular labs to make sure the medication is working against HIV and to check your kidney and liver

Common Side Effects for Emtriva

  • Changes in labs (30%)
  • Nausea (9%)
  • Fatigue (9%)
  • Diarrhea (9%)
  • Dizziness (8%)
  • Flu/cold (8%)
  • Runny nose (8%)
  • Rash (7%)

Warnings for Emtriva

  • WORSENING OF HEPATITIS B
  • IMMUNE RECONSTITUTION SYNDROME
  • LIVER PROBLEMS

Summary for Descovy

Prescription only

Descovy (emtricitabine / tenofovir alafenamide) is a prescription antiretroviral pill used to treat and prevent human immunodeficiency virus (HIV) infection. It's FDA approved for use with other HIV medications to treat HIV in adults and children. It's also approved for pre-exposure prophylaxis (PrEP) to help reduce the risk of getting HIV in adults and teens. You take it once a day by mouth, with or without food. Some common side effects include nausea and diarrhea.

Indications for Descovy

  • HIV treatment, in combination with other HIV medications - adults and children
  • Prevention of HIV infection (PrEP) - adults and teens

Pros and Cons for Descovy

Pros

Cons

  • Not approved for PrEP in people at risk from vaginal sex
  • Common side effects are diarrhea and nausea
  • Requires regular lab tests

Common Side Effects for Descovy

  • Diarrhea (5%)
  • Nausea (4%)

Note: Side effects were reported by people who took Descovy (emtricitabine / tenofovir alafenamide) alone for PrEP.

Warnings for Descovy

  • Worsening of hepatitis B infection
  • Take extra steps to prevent HIV when used for PrEP
  • Overactive immune system
  • Kidney problems
  • Liver problems and lactic acidosis

Prices with our coupons for Emtriva vs. Descovy

Price Card Drug Icon
Emtricitabine30 capsules / 200mg of
$152.24-
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Descovy30 tablets / 200mg/25mg
$2,157.90$2,809.99
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