Key takeaways
Lamivudine (Epivir) and didanosine (Videx) are both antiretroviral (ARV) medications used to treat HIV, but they have some key differences. Lamivudine (Epivir) is still available in both brand and generic forms, while didanosine (Videx) has been discontinued in the U.S. due to serious side effects and limited demand. Lamivudine (Epivir) is also used to treat hepatitis B virus (HBV), whereas didanosine (Videx) was only used for HIV. Lamivudine (Epivir) is typically taken once or twice daily and can be used in both adults and children, while didanosine (Videx) had more restrictions and interactions with other HIV medications. Common side effects of lamivudine (Epivir) include headache, nausea, and feeling tired, whereas didanosine (Videx) was known for more severe side effects, which contributed to its discontinuation.
