Key takeaways
Lamivudine (Epivir) and Pegasys (peginterferon alfa-2a) are both used to treat hepatitis B, but they work differently and have different uses. Lamivudine (Epivir) is a nucleoside reverse transcriptase inhibitor (NRTI) taken orally, while Pegasys (peginterferon alfa-2a) is an interferon alpha given as an injection. Lamivudine (Epivir) is also used to treat HIV, whereas Pegasys (peginterferon alfa-2a) is used for hepatitis C in combination with other medications. Lamivudine (Epivir) is typically taken once or twice daily, while Pegasys (peginterferon alfa-2a) is injected once a week. Common side effects of lamivudine (Epivir) include headache, nausea, and tiredness, while Pegasys (peginterferon alfa-2a) can cause flu-like symptoms, depression, and serious infections. Lamivudine (Epivir) is available in both brand and generic forms, but Pegasys (peginterferon alfa-2a) does not have a generic version.
