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Emtriva vs. Vemlidy

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Emtriva (emtricitabine) and Vemlidy (tenofovir alafenamide) are both antiretroviral medications used to treat viral infections, but they have different primary uses. While both medications are used for HIV treatment in combination with other HIV medications, while Vemlidy is primarily for hepatitis B virus (HBV) treatment. Both medications belong to the nucleoside reverse transcriptase inhibitor (NRTI) class, which helps stop viruses from making copies of themselves. Emtriva is available as a capsule and oral solution, and it is taken once daily, with or without food. Vemlidy is taken as a tablet once daily with food. Emtriva is available in generic form, while Vemlidy is only available as a brand-name medication. Common side effects of Emtriva include nausea, fatigue, and dizziness, whereas Vemlidy may cause headache, stomach pain, and cough. Emtriva requires dose adjustments for kidney problems, while Vemlidy is less harmful to kidneys and bones compared to other similar medications. If you have both HIV and HBV, you should not take Vemlidy alone, as it is not effective for treating HIV by itself.

Emtricitabine

(Emtriva)

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Vemlidy

(tenofovir alafenamide)

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Summary for Emtriva

Prescription only

Emtricitabine (Emtriva) is a first choice HIV antiretroviral (ARV) used in combination with other HIV ARVs for the treatment and prevention of HIV. It is one of the most common HIV ARVs used around the world.

Indications for Emtriva

  • HIV treatment

Pros and Cons for Emtriva

Pros

  • Very effective against HIV, with few side effects
  • Taken only once a day with or without food
  • Available in many combination tablets with other HIV ARVs
  • Available as a capsule and oral solution
  • Can be used in pregnancy and in children right after they are born

Cons

  • Dose must be adjusted if you have kidney problems
  • Must be used in combination with other HIV ARVs
  • The oral solution is absorbed less than the capsule, so the dose is higher
  • Some people with hepatitis B virus (HBV) have worsening of the liver after stopping emtricitabine (Emtriva)
  • Requires regular labs to make sure the medication is working against HIV and to check your kidney and liver

Common Side Effects for Emtriva

  • Changes in labs (30%)
  • Nausea (9%)
  • Fatigue (9%)
  • Diarrhea (9%)
  • Dizziness (8%)
  • Flu/cold (8%)
  • Runny nose (8%)
  • Rash (7%)

Warnings for Emtriva

  • WORSENING OF HEPATITIS B
  • IMMUNE RECONSTITUTION SYNDROME
  • LIVER PROBLEMS

Summary for Vemlidy

Prescription only

Vemlidy (tenofovir alafenamide), also known as TAF, is a first-choice medication for treating hepatitis B virus (HBV) for adults and children ages 6 years and older weighing at least 55 lbs. Tenofovir alafenamide is also found in combination with other antiretrovirals in medications such as Biktarvy to treat human immunodeficiency virus (HIV). Vemlidy (tenofovir alafenamide) is taken by mouth, typically once daily. Some of the more common side effects of Vemlidy (tenofovir alafenamide) include headache, stomach pain, and cough.

Indications for Vemlidy

  • Hepatitis B virus (HBV) in people ages 6 years and older weighing at least 55 lbs

Pros and Cons for Vemlidy

Pros

  • A first-choice medication to treat hepatitis B
  • Only taken once a day
  • Not as harmful to your kidneys and bones compared to Viread (tenofovir disoproxil fumarate)
  • Can be taken by most people with kidney problems

Cons

  • Can't take Vemlidy (tenofovir alafenamide) alone if you're co-infected with both HIV and hepatitis B
  • Currently only available as brand-name medication
  • Must be taken with food
  • Can cause worsening of hepatitis B if stopped all of a sudden

Common Side Effects for Vemlidy

  • Headache (12%)
  • Stomach pain (9%)
  • Cough (8%)
  • Back pain (6%)
  • Tiredness (6%)
  • Nausea (6%)

Warnings for Vemlidy

  • Worsening of hepatitis B
  • Hepatitis B and HIV coinfection
  • Kidney problems
  • Liver problems

Prices with our coupons for Emtriva vs. Vemlidy

Price Card Drug Icon
Emtricitabine30 capsules / 200mg
$152.24-
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Vemlidy30 tablets / 25mg
$1,481.37-
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