Key takeaways
Emtricitabine (Emtriva) and entecavir (Baraclude) are both nucleoside reverse transcriptase inhibitors (NRTIs) used to treat viral infections, but they target different viruses. Emtricitabine is primarily used for HIV treatment, while entecavir is used for hepatitis B. Emtricitabine is available as a capsule and oral solution, and is taken once daily, with or without food. Entecavir is available as a tablet and liquid solution, and must be taken on an empty stomach. Both medications are available in a generic form. Common side effects of emtricitabine include nausea and fatigue, while entecavir may cause headache and dizziness. Both medications require dose adjustments for kidney problems, but entecavir is not recommended for people with both hepatitis B and untreated HIV due to potential drug resistance.
