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Compare Stribild vs. Complera

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Stribild (elvitegravir/cobicistat/emtricitabine/tenofovir) and Complera (emtricitabine/rilpivirine/tenofovir) are both single-tablet regimens used for the treatment of HIV. Stribild includes an integrase inhibitor (elvitegravir) and a booster (cobicistat), while Complera contains a non-nucleoside reverse transcriptase inhibitor (NNRTI) (rilpivirine). Both medications must be taken with food to ensure proper absorption, but Stribild can be taken with any meal, whereas Complera should be taken with at least 400 calories. Stribild is not recommended for people with kidney or liver problems, and Complera, on the other hand, is not recommended for people with high viral loads. Both medications have many drug interactions and can cause kidney and bone problems, but Complera is also associated with mood changes and depression. Stribild is not a preferred option during pregnancy, while Complera can be used during pregnancy but not during breastfeeding.

  • Stribild
    Complera
  • Stribild
    Complera

  • Summary of Stribild vs. Complera

    Summary for HIV ARV Combo
    Prescription only

    Stribild is a single-tablet-regimen containing 3 HIV antiretrovirals (ARVs), elvitegravir (Vitekta), emtricitabine (Emtriva), and tenofovir DF (Viread), and one booster medication, cobicistat (Tybost).

    Summary for HIV ARV Combo
    Prescription only

    Complera is a single-tablet regimen containing 3 HIV antiretrovirals (ARVs), rilpivirine (Edurant), emtricitabine (Emtriva), and tenofovir disoproxil fumarate (Viread). It's no longer a first-choice treatment option due to newer agents with fewer side effects.

  • Indications of Stribild vs. Complera

    Indications for
    •HIV treatment
    Indications for
    •HIV treatment

  • Pros and Cons of Stribild vs. Complera

    Pros and Const for HIV ARV Combo
    Pros
    •1 tablet once a day is a full HIV regimen
    •Contains tenofovir, which is also a first-choice treatment option for hepatitis B
    •One of the few single-tablet-regimens that contains an integrase inhibitor (a preferred HIV ARV subclass)
    •In clinical trials, caused less abnormal dreams than Atripla
    •Gilead copay card available for people with commercial health plans (not for use with Medicaid and Medicare plans)
    Cons
    •Must be taken with food
    •Dose can't be adjusted, so it's not recommended for people with kidney or liver problems
    •Can cause kidney and bone problems
    •Interacts with a lot of medications
    •Not a good option for people who are pregnant, or plan to become pregnant
    Pros and Const for HIV ARV Combo
    Pros
    •1 tablet once a day is a full HIV regimen
    •Can be used in pregnancy at the same dose
    •Contains tenofovir, which is also a first-choice treatment option for hepatitis B
    •Causes less abnormal dreams when compared to a similar medication Atripla
    •Not associated with weight gain
    Cons
    •Must be taken with food
    •Not recommended for people with kidney problems since the dose can't be adjusted
    •Can't be used if the amount of virus (viral load) is too high
    •There are many medication interactions and it can't be taken with some medications used to treat tuberculosis, seizures, and stomach acid.
    •Can lead to kidney and bone problems

  • Common Side Effects of Stribild vs. Complera

    Common Side Effects for
    •Nausea (16%)
    •Diarrhea (12%)
    •Abnormal, strange dreams (9%)
    •Headache (7%)
    Common Side Effects for
    •Change in mood, depression (2%)
    •Headache (2%)
    •Trouble sleeping, insomnia (2%)

  • Warnings of Stribild vs. Complera

    Common Side Effects for
    •WORSENING OF HEPATITIS B
    •CHANGES IN KIDNEY FUNCTION
    •LIVER PROBLEMS
    •DRUG INTERACTIONS
    •BONE PROBLEMS
    •IMMUNE RECONSTITUTION SYNDROME
    Common Side Effects for
    •WORSENING OF HEPATITIS B
    •LIVER PROBLEMS AND TOXICITY
    •DEPRESSION AND CHANGES IN MOOD
    •KIDNEY PROBLEMS
    •BONE PROBLEMS
    •IMMUNE RECONSTITUTION SYNDROME

  • Prices with our coupons for Stribild vs. Complera

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