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Compare Dovato vs. Odefsey

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Dovato (dolutegravir/lamivudine) and Odefsey (emtricitabine/rilpivirine/tenofovir alafenamide) are both used to treat HIV, but they have some key differences. Dovato combines two antiretrovirals (ARVs) into one pill, while Odefsey combines three ARVs. Dovato is taken once daily and can be taken with or without food, whereas Odefsey must be taken with a meal containing at least 400 calories. Dovato is not recommended for people with severe kidney or liver problems, while Odefsey is safer for your kidneys and bones compared to older treatments like Complera. However, Odefsey has more dietary restrictions. Both medications have interactions with other medications, such as those for tuberculosis and seizures. Both medications can cause side effects like headaches and sleep problems, but Dovato has a higher risk of weight gain and serious allergic reactions.

  • Dovato (dolutegravir / lamivudine)
    Odefsey
  • Dovato (dolutegravir / lamivudine)
    Odefsey

  • Summary of Dovato vs. Odefsey

    Summary for HIV ARV
    Prescription only

    Dovato (dolutegravir / lamivudine) is used to treat human immunodeficiency virus (HIV) infections. It's considered a complete HIV treatment regimen with only two antiretroviral (ARV) medications: dolutegravir and lamivudine. One of the benefits of Dovato (dolutegravir / lamivudine) is that it combines two medications into a single tablet so it's convenient to take. Possible side effects of Dovato (dolutegravir / lamivudine) can include headache and weight gain, but they aren't very common with this medication.

    Summary for HIV ARV Combo
    Prescription only

    Odefsey is a single-tablet-regimen containing 3 HIV antiretrovirals (ARVs), rilpivirine (Edurant), emtricitabine (Emtriva), and tenofovir AF (Vemlidy). It's similar to Complera, but contains a newer version of tenofovir which causes less harmful effects on your kidneys and bones.

  • Indications of Dovato vs. Odefsey

    Indications for
    •Treatment of HIV infection in adults
    Indications for
    •HIV treatment

  • Pros and Cons of Dovato vs. Odefsey

    Pros and Const for HIV ARV
    Pros
    •First-choice treatment option for most adults starting HIV medications
    •Only contains two ARVs and is considered a complete HIV treatment regimen, which is less medications than other complete regimens
    •Combines two medications into one pill for convenience
    •Only taken once a day
    •Can take with or without food
    Cons
    •Interacts with a lot of medications, such as anti-seizure medications (e.g., oxcarbazepine (Trileptal)), metformin, and antacids
    •Can't take with dofetilide (Tikosyn) because of risk of serious side effects
    •Not approved for use in children
    •Not recommended for use if you have severe kidney or liver problems
    •Shouldn't use if you have both HIV and hepatitis B (HBV)
    Pros and Const for HIV ARV Combo
    Pros
    •1 tablet once a day is a full HIV regimen
    •Safer for your kidneys and bones when compared to Complera
    •Can be used in pregnancy at the same dose
    •Contains tenofovir, which is also a first-choice treatment option for hepatitis B
    •Not too many side effects
    Cons
    •Must be taken with a light meal
    •Dose can't be adjusted
    •Can't be used if the amount of virus (viral load) is too high
    •There are many medication interactions and it can't be taken with some medications used to treat tuberculosis, seizures, and stomach acid.
    •Not a first-choice treatment option for people new to HIV medications

  • Common Side Effects of Dovato vs. Odefsey

    Common Side Effects for
    •Higher blood sugar levels (up to 11%)
    •Lower phosphate levels (up to 11%)
    •Higher creatine kinase levels in the blood (up to 8%)
    •Higher lipase levels (up to 7%)
    •Abnormal liver labs (up to 5%)
    •Headache (3%)
    •Weight gain (3%)
    •Nausea (2%)
    •Diarrhea (2%)
    •Trouble sleeping (2%)
    •Feeling tired (2%)
    •Anxiety (2%)
    Common Side Effects for
    •Headache (2%)
    •Sleep problems (2%)

  • Warnings of Dovato vs. Odefsey

    Common Side Effects for
    •Worsening of hepatitis B infection if you have HIV and hepatitis B
    •Allergic reaction
    •Liver problems and lactic acidosis
    •Overactive immune system
    •Interaction with other medications
    •Harm to unborn baby
    Common Side Effects for
    •WORSENING OF HEPATITIS B
    •LIVER PROBLEMS AND TOXICITY
    •DEPRESSION AND CHANGES IN MOOD
    •KIDNEY PROBLEMS
    •BONE PROBLEMS
    •IMMUNE RECONSTITUTION SYNDROME

  • Prices with our coupons for Dovato vs. Odefsey

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