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Edurant Coupon - Edurant 25mg tablet

Edurant

rilpivirine
Used for HIV Treatment
Used for HIV Treatment

Edurant (rilpivirine) is a once-daily antiretroviral medication that's taken by mouth and is used to treat human immunodeficiency virus (HIV) infection. It's approved for use in adults and children. Edurant (rilpivirine) is taken with other antiretroviral medications when it's used for certain people who've never had HIV treatment before. Edurant (rilpivirine) can also be used for a short period of time before starting Cabenuva (cabotegravir / rilpivirine). Side effects of Edurant (rilpivirine) can include depression, headache, and trouble sleeping.

Reviewed by:
reviewer
Ally Tsai, PharmD
reviewer
Allison Gourley, PharmD
Last reviewed on February 21, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Edurant (rilpivirine)?

What is Edurant (rilpivirine) used for?

  • Treatment of HIV-1 infection in people 2 years and older, weighing at least 30 pounds, with an HIV viral load of less than 100,000 copies/mL and who haven't taken HIV medications before

  • Short-term treatment of HIV-1 infection in certain people ages 12 years and older, weighing at least 77 pounds, who are planning to start or planning to miss a dose of Cabenuva (cabotegravir / rilpivirine)

How Edurant (rilpivirine) works

Edurant (rilpivirine) is an HIV antiretroviral medication that's known as a non-nucleoside reverse transcriptase inhibitor (NNRTI). It blocks an enzyme called reverse transcriptase that helps HIV make copies of itself. By blocking this enzyme, the medication prevents HIV from spreading.

Drug Facts

Common BrandsEdurant
Drug ClassHIV ARV
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Edurant (rilpivirine)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

  • Belly pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Low appetite
  • Feeling tired
  • Dizziness
  • Abnormal dreams
  • Anxiety
Note: Side effects were reported by people who took Edurant (rilpivirine) with other HIV antiretroviral medications.

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Suicidal thoughts and behaviors
  • Serious allergic reactions: mouth sores; trouble breathing; rash; fever; swelling in your face, lips, or tongue
  • Liver problems: upper right stomach pain, nausea, yellowing of the skin or whites of the eyes, dark urine

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Changes in behavior

cloudy or bloody urine

discouragement

feeling sad or empty

gaseous stomach pain

indigestion

irritability

lack of appetite

loss of interest or pleasure

recurrent fever

severe nausea or vomiting

stomach fullness

swelling of the face, feet, or lower legs

thoughts of killing oneself

tiredness

trouble concentrating

trouble sleeping

yellow eyes or skin

Incidence not known

Blurred vision

chills

cough

dizziness

fever

headache

hives, itching, skin rash

hoarseness

irritation

joint pain, stiffness, or swelling

nervousness

pounding in the ears

redness of the skin

slow or fast heartbeat

sore throat

swollen, painful, or tender lymph glands in the neck, armpit, or groin

tightness in the chest

trouble breathing or swallowing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Abnormal dreams

diarrhea

fear

nausea

sleepiness or unusual drowsiness

stomach discomfort

unusual tiredness or weakness

vomiting

Incidence not known

Decreased amount of fat from your legs, arms, or face

increased amount of fat in the upper back and neck, or around the chest and stomach area

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Edurant (rilpivirine)

thumbs-up

Pros

Taken by mouth once a day, so it's convenient for people with a busy schedule

Can use in people with mild-to-moderate kidney and liver problems

Safe to use during pregnancy

thumbs-down

Cons

Can cause some allergic skin reactions

Must take with a meal

Only available as a brand-name medication

pharmacist-tips

Pharmacist tips for Edurant (rilpivirine)

pharmacist

  • It's important to take Edurant (rilpivirine) around the same time every day with food. Taking it with food can help your body absorb this medication better.

    • If you accidentally forget to take Edurant (rilpivirine), take your missed dose as soon as possible and tell your care team. Missing doses often can make it easier for HIV to change form and cause Edurant (rilpivirine) to stop working.

      • Edurant (rilpivirine) is available in two different forms: Edurant tablets and Edurant Ped tablets for oral suspension. They can't be substituted for each other since the dosages don't match. Make sure that you or your child is taking the right one.

        • If you're switching from Edurant (rilpivirine) and Vocabria (cabotegravir) to Cabenuva (cabotegravir / rilpivirine) injections, follow your care team's instructions on how to make the transition. Typically, you can get your first injection of Cabenuva on the day that you take your last doses of Edurant (rilpivirine) and Vocabria (cabotegravir).

          • Be sure to get your routine blood tests done on time while you’re taking Edurant (rilpivirine). These blood tests help your HIV care team check that the medication is working for you and not causing side effects. Your care team will check your HIV viral load and for changes to your liver function.

            • Edurant (rilpivirine) might not always protect you from HIV. It also doesn't protect you from hepatitis or other sexually transmitted diseases (STDs). Always use a condom along with Edurant (rilpivirine) to help lower your risk of an infection.

              • Let your HIV specialist know if you experience symptoms of depression or worsening mood while you're taking Edurant (rilpivirine). In cases of serious depression, your HIV specialist might ask you to stop taking the medication and switch you to another.

                • Let your care team know what medications you're taking or planning to take. These include any prescription medications, over-the-counter products, and supplements. Since Edurant (rilpivirine) can interact with many medications, your care team can check to make sure your medications are safe to take together. Talk with your care team if you have any questions about interactions with this medication.

                  • Tell your HIV specialist if you notice any changes in weight while you're taking Edurant (rilpivirine). Let your care team know if you have nausea, vomiting, or diarrhea that won’t go away since they can also lead to weight loss.

                    More tips for Edurant (rilpivirine) Peds:

                    • Place the tablets for oral suspension in a cup and add 5 mL (1 teaspoon) of room temperature water. Don't crush the tablets. Swirl the cup gently for 1–2 minutes until the mixture looks cloudy.

                      • Have your child drink the suspension immediately. If needed, you can add another 5 mL (1 teaspoon) of water, milk, orange juice, or applesauce to help. Swirl and have your child drink it right away, using a spoon if necessary.

                        • Make sure your child takes the entire dose. If any medicine is left in the cup, add another 5 mL (1 teaspoon) of water (or other liquid or soft foods), swirl, and have them drink immediately.

                          faqs

                          Frequently asked questions about Edurant (rilpivirine)

                          How long do the Edurant (rilpivirine) side effects last?
                          How long Edurant (rilpivirine) side effects last can differ depending on which side effects you're experiencing. For example, some people can have side effects like nausea, trouble sleeping, and fatigue; these side effects typically start to improve or go away after a few days or weeks of treatment. Keep in mind that not all side effects will go away on their own and you might sometimes need more medical attention (such as with side effects like depression or liver problems). Talk with your care team if you're struggling with a particular side effect of Edurant (rilpivirine).
                          Can you take Edurant (rilpivirine) with omeprazole?
                          Avoid taking Edurant (rilpivirine) with certain heartburn medications, such as omeprazole (Prilosec). This is because proton pump inhibitors (PPIs), like omeprazole (Prilosec) and lansoprazole (Prevacid), raise how acidic your stomach gets. This can lower the amount of Edurant (rilpivirine) that gets absorbed into the body, which can cause the medication to work less well and worsen your HIV-1 infection. Speak with your HIV specialist or a pharmacist about alternative heartburn medications and how to safely take them with Edurant (rilpivirine).
                          Is Edurant (rilpivirine) safe for children?
                          For those who haven't been treated with HIV before, Edurant (rilpivirine) is safe to use in children 2 years and older who weigh at least 30 pounds. For short-term treatment of HIV infection, the medication is approved for children 12 years and older who weigh at least 77 pounds. Tell your child's HIV care team if your child has any significant weight loss during treatment with Edurant (rilpivirine). Also let the care team know if your child has nausea, vomiting, or diarrhea that won’t go away since severe cases of these side effects can contribute to weight loss.
                          Can I take Edurant (rilpivirine) if I'm pregnant?
                          Yes. It seems like Edurant (rilpivirine) doesn't raise the risk of harm to your unborn baby. If you become pregnant while taking Edurant (rilpivirine), your HIV specialist might recommend continuing the medication at 25 mg by mouth once a day. In addition, you’re encouraged to enroll in the Antiretroviral Pregnancy Registry (APR). This registry monitors and collects information about your health and your baby's health while you're taking Edurant (rilpivirine). Learn more about this registry by calling 1-800-258-4263.
                          Why do I need to take Edurant (rilpivirine) before I start Cabenuva (cabotegravir / rilpivirine) injection?
                          Medications containing rilpivirine can cause serious skin and allergic reactions. Taking Edurant (rilpivirine) — the tablet form of rilpivirine — before you start getting injections of Cabenuva (cabotegravir / rilpivirine) can help your care team see how your body reacts to the ingredients of Cabenuva. If you have a reaction to rilpivirine, it's a lot easier for your body to get rid of the medication in the tablet form than in injection form (which lasts longer in the body). Your HIV specialist will typically prescribe Edurant (rilpivirine) for about a month before you start Cabenuva injections. Once you've started getting routine Cabenuva injections, you won't have to take any more daily Edurant (rilpivirine) tablets. Talk with your care team if you have questions about how to transition from the tablets to the injections.
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                          What are the risks and warnings for Edurant (rilpivirine)?

                          Edurant (rilpivirine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                          risk-warning

                          Severe skin reactions and allergic reactions

                          Edurant (rilpivirine) can sometimes cause rash and other severe skin reactions. In rare cases, these skin reactions can lead to hospitalization and other complications. Severe skin reactions can happen at any time while you're taking Edurant (rilpivirine), but they're most common within 4 to 6 weeks of starting treatment. Get medical care right away if you have a rash, blistering, peeling skin, mouth sores, swelling, or trouble breathing.

                          Note that certain severe allergic reactions, such as drug reaction with eosinophilia and systemic symptoms (DRESS), can happen with or without a rash. Although these reactions are rare, they can cause organ failure or blood problems. Get medical help as soon as possible if you have signs like sudden rash, mouth sores, fever, chills, body aches, or swollen lymph nodes.

                          risk-warning

                          Liver problems

                          • Risk factor: Past liver problems | Hepatitis B or C

                            Some people have had liver problems while they were taking Edurant (rilpivirine). This risk might be higher if you've had past liver problems like hepatitis. Talk with your care team about your medical history before you start this medication to find the safest treatment option for you. You’ll need to get blood tests done while you take Edurant (rilpivirine) so your care team can check your liver health. Talk with your primary care provider or HIV specialist if you have signs and symptoms of liver damage, such as feeling sleepy, upper right stomach pain, yellowing of the skin or whites of the eyes, or dark urine.

                            risk-warning

                            Depression and suicidal thoughts

                            Some people have experienced depression, mood swings, and suicidal thoughts or attempt(s) while they were taking Edurant (rilpivirine). These mental health changes were mild or moderate during studies. Call your care team if you notice any mood changes. Your care team can try to see whether your symptoms are related to this medication. They'll also decide whether Edurant (rilpivirine) is still safe for you to continue taking. Call 911 right away if you or a loved one notices that you have suicidal thoughts or behavior.

                            risk-warning

                            Overactive immune system

                            Taking Edurant (rilpivirine) with other antiretroviral medications can cause changes to your immune system and lead to immune reconstitution syndrome. This medical condition happens when your immune system becomes more active after you start HIV treatment. Your immune system begins to fight off different infections that it was too weak to fight off before you started treatment.

                            In rare cases, your immune system might improve so much with treatment that it starts to attack normal cells in your body. This can lead to autoimmune problems, which can appear as early as during the first few weeks of starting treatment or many months later. Tell your care team right away if you start having any new symptoms, such as fever, pain, hair loss, bulging eyes, or sweating, after you start Edurant (rilpivirine).

                            risk-warning

                            Interaction with other medications

                            Edurant (rilpivirine) interacts with many medications. Some medications can cause the amount of Edurant (rilpivirine) in your body to drop. This can make the HIV medication work less well to treat your infection. Examples of medications to avoid because of this risk include certain medications for seizures (e.g., carbamazepine (Tegretol)), dexamethasone (more than one dose), St. John’s wort, and certain antibiotics (e.g., rifampin (Rifadin)).

                            Edurant (rilpivirine) can also raise the amount of other medications in your body when taken together. This raises your risk for side effects from those other medications. For example, taking Edurant (rilpivirine) with antibiotics like clarithromycin or erythromycin can put you at risk for serious heart problems.

                            Because of the potential for serious interactions with Edurant (rilpivirine) and various medications, let your care team know what other medications you’re taking or planning to take with Edurant (rilpivirine). Your care team can make sure your medications are safe to take together.

                            dosage

                            Edurant (rilpivirine) dosage forms

                            The average cost for 30 tablets of 25mg of Edurant (rilpivirine) is $1457.71 with a free GoodRx coupon. This is 15.99% off the average retail price of $1735.19.
                            tablet
                            Tablet
                            DosageQuantityPrice as low asPrice per unit
                            25mg30 tablets$1457.71$48.59

                            Typical dosing for Edurant (rilpivirine)

                            This medication is available in two different forms: Edurant tablets (for adults and children weighing at least 55 lbs) and Edurant Ped tablets for oral suspension (for children weighing at least 30 lbs to less than 44 lbs).

                            • Treatment of HIV-1:

                              • Adults: The typical dose is 25 mg by mouth once a day with a meal. Edurant (rilpivirine) is taken with other antiretroviral medications.

                              • Children: Your child's dose will depend on their weight.

                                • 30 lbs to less than 44 lbs: The typical dose is 12.5 mg Edurant Ped by mouth once a day with a meal.

                                • 44 lbs to less than 55 lbs: The typical dose is 15 mg Edurant Ped by mouth once a day with a meal.

                                • More than or equal to 55 lbs: The typical dose is 25 mg Edurant (rilpivirine) by mouth once a day with a meal.

                            • Short-term treatment of HIV-1 before starting Cabunuva (cabotegravir / rilpivirine): The typical dose is 25 mg by mouth once a day with a meal for about 1 month (at least 28 days). It's taken together with Vocabria (cabotegravir).

                            • Replacing a missed injection of Cabenuva (cabotegravir / rilpivirine): Your HIV specialist might prescribe Edurant (rilpivirine) for you to take for a short while if you're getting Cabenuva injections for HIV but will miss an injection because of a schedule conflict (e.g., traveling). The typical dose of Edurant (rilpivirine) is 25 mg by mouth once a day with a meal and with Vocabria (cabotegravir). This combination is only meant to be taken for up to 2 months to replace missed injections.

                            interactions

                            Interactions between Edurant (rilpivirine) and other drugs

                            Edurant (rilpivirine) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Edurant (rilpivirine). Please note that only the generic name of each medication is listed below.

                            Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                            Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                            Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                            • Boceprevir
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                            contraindications-icon

                            Edurant (rilpivirine) contraindications

                            Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Edurant (rilpivirine) will not be safe for you to take.
                            alternatives

                            What are alternatives to Edurant (rilpivirine)?

                            There are a number of medications that your doctor can prescribe in place of Edurant (rilpivirine). Compare a few possible alternatives below.
                            Edurant (rilpivirine)
                            Used for:

                            • Treatment of HIV-1 infection in people 2 years and older, weighing at least 30 pounds, with an HIV viral load of less than 100,000 copies/mL and who haven't taken HIV medications before

                            • Short-term treatment of HIV-1 infection in certain people ages 12 years and older, weighing at least 77 pounds, who are planning to start or planning to miss a dose of Cabenuva (cabotegravir / rilpivirine)

                            $1457.71 Lowest GoodRx priceView Prices
                            Efavirenz (Sustiva)
                            Used for:

                            • Treatment of HIV infection in people ages 3 months and older

                            $37.63 Lowest GoodRx priceView Prices
                            Etravirine (Intelence)
                            Used for:

                            • Treatment of HIV infection in people 2 years of age and older

                            $1069.42 Lowest GoodRx priceView Prices
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                            Edurant (rilpivirine) images

                            White Round 25 And Tmc - EDURANT 25mg Tablet
                            This medicine is White, Round Tablet Imprinted With "25" And "Tmc".White Round 25 And Tmc - EDURANT 25mg Tablet

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                            References

                            Best studies we found

                            ClinicalInfoHIV.gov. (n.d.). Immune reconstitution inflammatory syndrome (IRIS).

                            ClinicalInfoHIV.gov. (n.d.). Non-nucleoside reverse transcriptase inhibitor (NNRTI).

                            ClinicalInfoHIV.gov. (n.d). Reverse transcriptase (RT).

                            View All References (7)

                            ClinicalInfoHIV.gov. (n.d.). Viral load test.

                            HIV.gov. (2023). Taking your HIV medicine as prescribed.

                            HIVinfo.NIH.gov. (2021). HIV medicines and side effects.

                            Janssen Products, LP. (2024). Edurant- rilpivirine hydrochloride tablet, film coated; Edurant Ped- rilpivirine hydrochloride tablet, for suspension [package insert]. DailyMed.

                            Nyamweya, S., et al. (2013). Comparing HIV-1 and HIV-2 infection: Lessons for viral immunopathogenesis. Reviews in Medical Virology.

                            Thapa, S., et al. (2023). Immune reconstitution inflammatory syndrome. StatPearls.

                            U.S. Food and Drug Administration. (2021). FDA approves Cabenuva and Vocabria for the treatment of HIV-1 infection.

                            GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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