Medications for musculoskeletal conditions are used to treat muscle spasms, pain, and inflammation. Some of these medications can also manage muscle problems from certain genetic conditions. They work by relaxing muscles or reducing pain signals. Common classes include muscle relaxants and antidepressants. Muscle relaxants, like cyclobenzaprine and methocarbamol (Robaxin), are usually taken as oral pills. Antidepressants like duloxetine (Cymbalta) are typically taken as oral pills. These options provide different ways to help manage your musculoskeletal symptoms effectively.