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Antisense Therapeutics

Antisense therapeutics are used to treat certain types of genetic disorders or infections. Antisense therapeutics can work by making a nucleic acid that can "turn off" the particular gene that is causing the disease. They are often not a cure, but can maintain and treat symptoms.

Why are antisense therapeutics prescribed?

  1. ALS (25%)
  2. Muscular Dystrophy (25%)
  3. Hereditary Transthyretin-Mediated Amyloidosis (25%)
  4. Musculoskeletal Conditions (25%)

Key takeaways

Antisense therapeutics are used to treat conditions like Duchenne muscular dystrophy (DMD), spinal muscular atrophy (SMA), and hereditary transthyretin-mediated amyloidosis (hATTR). They also have other uses, such as treating amyotrophic lateral sclerosis (ALS). These medications work by altering specific genetic instructions to impact the production of certain proteins in the body. Antisense therapeutics come as different injectable options. Examples include Exondys 51 (eteplirsen), Spinraza (nusinersen), and Tegsedi (inotersen).

Prices for popular Antisense Therapeutics medications
Viewing 8 of 8 medications
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Viltepso

as low as$276
VILTOLARSEN treats Duchenne muscular dystrophy (DMD), an inherited condition that causes muscle weakness. It works by increasing the amount of dystrophin, a protein that is absent in people with DMD. This may improve muscle strength.
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Amondys 45

as low as$1,538
CASIMERSEN treats Duchenne muscular dystrophy (DMD), an inherited condition that causes muscle weakness. It works by increasing the amount of dystrophin, a protein that is absent in people with DMD. This may improve muscle strength.
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Vyondys 53

as low as$1,538
GOLODIRSEN treats Duchenne muscular dystrophy (DMD), an inherited condition that causes muscle weakness. It works by increasing the amount of dystrophin, a protein that is absent in people with DMD. This may improve muscle strength.
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Qalsody

as low as$14,455
TOFERSEN treats amyotrophic lateral sclerosis (ALS). It works by protecting nerve cells, which delays worsening symptoms.
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Exondys 51

ETEPLIRSEN treats Duchenne muscular dystrophy (DMD), an inherited condition that causes muscle weakness. It works by increasing the amount of dystrophin, a protein that is absent in people with DMD. This may improve muscle strength.
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Spinraza

NUSINERSEN is used to treat patients with spinal muscular atrophy (SMA). It is not a cure.\n \nThis medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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Tegsedi

INOTERSEN treats nerve pain, tingling, or numbness in the hands or feet in people with hereditary transthyretin-mediated amyloidosis (hATTR). It works by reducing the buildup of a protein in your body. This decreases the symptoms of hATTR.
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Wainua

Wainua (eplontersen) is used to treat Hereditary Transthyretin-Mediated Amyloidosis. Wainua is an Antisense Therapeutic, which works by making a nucleic acid that can "turn off" the particular gene that is causing the disease. Wainua is available as a 1.75mg/0.3ml autoinjector. There are currently no generic alternatives for Wainua. It is covered by some Medicare and insurance plans.
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Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

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