Compare
Glyxambi vs. Ozempic

Glyxambi (empagliflozin / linagliptin) is used to manage blood sugar levels in adults with Type 2 diabetes. It's a combination of 2 medications: empagliflozin (a sodium-glucose co-transporter 2 (SGLT2) inhibitor) and linagliptin (a dipeptidyl peptidase-4 (DPP-4) inhibitor). It lowers blood sugar by getting rid of extra sugar through your urine and helping your body make more insulin. Glyxambi (empagliflozin / linagliptin) is taken by mouth once daily. Some common side effects include urinary tract infections and upper respiratory tract infections.

• Type 2 diabetes in adults (when taken along with nutritious diet and regular exercise)
• Lowers risk of death from heart problems in adults with Type 2 diabetes and heart disease

• Urinary tract infection (11-13%)
• Upper respiratory tract infection (7%)

• Pancreas problems
• Ketoacidosis (too much acid in the blood)
• Low fluids in the body (leading to low blood pressure or dehydration, or kidney problems)
• Low blood sugar with other diabetes medications
• Genital and urinary tract infections
• Serious allergic or skin reactions
• Joint pain
• Leg and foot amputations
• Heart failure

Ozempic (semaglutide) is a GLP-1 agonist used with diet and exercise to help adults manage Type 2 diabetes. It can also lower the risk of heart attack, stroke, and heart-related death in some people with Type 2 diabetes. It comes as a once-weekly injection under the skin and as a tablet taken by mouth once a day. The injection is also approved to help slow worsening kidney problems in people with Type 2 diabetes and chronic kidney disease (CKD). Common side effects include nausea, vomiting, and diarrhea.

Injection:

• Type 2 diabetes
• Lower the risk of heart attack, stroke, and heart-related death in adults with Type 2 diabetes and heart disease
• Lower the risk of worsening kidney problems and heart-related death in adults with Type 2 diabetes and chronic kidney disease (CKD)

Tablets:

• Type 2 diabetes
• Lower the risk of heart attack, stroke, and heart-related death in adults with Type 2 diabetes at high risk for these events

• Nausea (16-20%)
• Diarrhea (9%)
• Vomiting (5-9%)
• Stomach pain (6-7%)
• Constipation (3-5%)

Note: Side effects listed above are for Ozempic (semaglutide) injection

• Risk of thyroid tumors
• Inflammation of the pancreas (pancreatitis)
• Eye problems
• Low blood sugar (hypoglycemia) when taken with certain diabetes medications
• Kidney damage
• Severe stomach problems
• Severe allergic reactions
• Gallbladder problems
• Lung problems during anesthesia or deep sedation