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Dupixent vs. Symbicort

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Dupixent (dupilumab) and Symbicort (budesonide/formoterol) are both prescription medications used to treat different inflammatory conditions, but they work in different ways and are used for different conditions. Dupixent is a biologic medication, specifically a monoclonal antibody, that is injected under the skin to treat conditions like eczema, asthma, and eosinophilic esophagitis. It works by blocking proteins that cause inflammation. Symbicort, on the other hand, is an inhaler that combines a corticosteroid (budesonide) and a long-acting beta-agonist (formoterol) to treat asthma and chronic obstructive pulmonary disease (COPD). It reduces inflammation in the lungs and relaxes airway muscles to make breathing easier. Dupixent is typically injected every other week or monthly, while Symbicort is inhaled twice daily. Dupixent does not have a generic version available, whereas Symbicort does. Common side effects of Dupixent include injection site reactions and eye inflammation, while Symbicort can cause symptoms like a common cold and thrush in the mouth.

Dupixent

(dupilumab)

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Symbicort

(budesonide / formoterol)

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Summary for Dupixent

Prescription only

Dupixent (dupilumab) is an injection that helps treat certain inflammatory conditions. This includes eczema, asthma, and chronic obstructive pulmonary disease (COPD), among others. It's a biologic medication known as an interleukin antagonist that lowers inflammation. Dupixent (dupilumab) comes as prefilled pens and prefilled syringes. It's injected under the skin of the belly or thighs (or in the back of the upper arm with someone's help). The dosing schedule depends on the condition you have, your age, and your weight. It's injected either every week, every 2 weeks, or every 4 weeks. Side effects include injection site reactions and eye problems.

Indications for Dupixent

Pros and Cons for Dupixent

Pros

  • Taken every other week or monthly for most conditions
  • Approved for some children (specific age depends on the condition)
  • Available as prefilled pens (for people ages 2 years and older)
  • Available as prefilled syringes (for people ages 6 months and older)

Cons

  • Given as an injection under the skin
  • Not used for helping with asthma attacks
  • Can cause injection reactions, such as pain, bruising, and swelling
  • Unknown if it's safe or works well while pregnant or breastfeeding

Common Side Effects for Dupixent

  • Injection site reaction (e.g., pain, swelling, bruising; 10%)
  • Eye redness or eye inflammation (10%)
  • Cold sores (4%)

Warnings for Dupixent

  • Allergic reactions
  • Eye inflammation
  • Other inflammation in the body
  • Risk of worsening of breathing problems in people with asthma or COPD
  • Risk of psoriasis
  • Joint pain and psoriatic arthritis
  • Unknown effect in people with parasitic worm infections
  • Interaction with vaccines

Summary for Symbicort

Prescription only

Symbicort (budesonide / formoterol) is a combination inhaler used to treat asthma and chronic obstructive pulmonary disease (COPD). It contains two medications: budesonide, a steroid, and formoterol, a long-acting beta-agonist (LABA). Both medications work together to reduce inflammation in the lungs and open up your airways. The typical dose is two puffs by mouth twice a day, usually about 12 hours apart. Common side effects include common cold symptoms, headache, and sore throat.

Indications for Symbicort

Pros and Cons for Symbicort

Pros

  • Long-term treatment for both COPD and asthma
  • Might feel relief in as soon as 15 minutes for asthma
  • Safe for children 6 years and older for asthma
  • Combines two medications into one inhaler for convenience

Cons

  • Won't work well for asthma attacks or COPD flare ups
  • Can cause thrush in mouth or throat as a side effect
  • Taken 2 times a day
  • Possible bone loss if used for a long time

Common Side Effects for Symbicort

Asthma:

  • Common cold symptoms (10-11%)
  • Upper respiratory tract infection (8-11%)
  • Headache (7-11%)
  • Sore throat (6-9%)
  • Sinus infection (5-6%)

COPD:

  • Common cold symptoms (7%)
  • Oral thrush (6%)
  • Bronchitis (5%)

Warnings for Symbicort

  • Worsening asthma or COPD
  • Overdose
  • Oral thrush
  • Pneumonia
  • Higher risk of infection
  • Changes in stress hormone levels
  • Sudden narrowing of the airways
  • Serious allergic reaction
  • Heart and nervous system problems
  • Risk of bone loss
  • Poor growth
  • Eye problems
  • Low potassium and high blood sugar

Prices with our coupons for Dupixent vs. Symbicort

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Dupixent2 cartons / 2 pens of 300mg/2ml
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Breyna1 inhaler / 120 doses of 160mcg/4.5mcg
$92.01$169.72
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