CGRP blockers are used to treat and prevent migraines. These medications work by blocking calcitonin gene-related peptide (CGRP) or the receptors that it binds to, which helps to reduce the frequency and severity of migraine headaches. CGRP blockers come in different forms, including oral pills, injections, and nasal sprays. Examples include Nurtec ODT (rimegepant), Ubrelvy (ubrogepant), Aimovig (erenumab), and, Zavzpret (zavegepant).