Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Emgality (galcanezumab) and Maxalt (rizatriptan) are both used to manage migraines, but they work differently and are used in different ways. Emgality is a monoclonal antibody that prevents migraines and treats cluster headaches by blocking a protein called calcitonin-gene related peptide (CGRP). It is given as a monthly injection under the skin. Common side effects include pain and rash at the injection site. On the other hand, Maxalt is a triptan that treats migraines by tightening blood vessels and reducing inflammation. It is taken as an oral tablet or an orally disintegrating tablet (ODT) when a migraine starts. Maxalt can cause dizziness and sleepiness and is available as a lower-cost generic. Emgality is not available in a generic form. Emgality is used for prevention, while Maxalt is used for immediate relief during a migraine attack.
Emgality (galcanezumab)
Rizatriptan (Maxalt)
Emgality (galcanezumab)
Rizatriptan (Maxalt)
Summary of Emgality vs. Maxalt
Summary for Monoclonal antibody
Prescription only
Emgality (galcanezumab or galcanezumab-gnlm) is a monoclonal antibody that's used to prevent migraine attacks and to treat cluster headaches in adults. Emgality (galcanezumab) works by blocking a specific protein in the brain that can cause migraines and headaches. This medication is injected under the skin monthly. Some common side effects of Emgality (galcanezumab) include pain, itching, and rash at the injection site.
Summary for Triptan
Prescription only
Rizatriptan (Maxalt) is used to treat migraines with or without aura in people ages 6 years and older. Rizatriptan (Maxalt) is available as a lower-cost generic tablet and an orally disintegrating tablet (ODT) that's placed on the tongue. Common side effects include dizziness, headache, and sleepiness. It can interact with antidepressants and other similar migraine medications.