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Compare Reyvow vs. Ajovy

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Reyvow (lasmiditan) and Ajovy (fremanezumab) are both used to manage migraines, but they have different purposes and methods of administration. Reyvow (lasmiditan) is a serotonin agonist taken orally to treat migraines when they occur, while Ajovy (fremanezumab) is a CGRP receptor blocker injected under the skin to prevent migraines. Reyvow (lasmiditan) can relieve migraine pain within two hours but may cause dizziness and sleepiness, requiring you to avoid driving for at least eight hours after taking it. Ajovy (fremanezumab) is taken either once a month or once every three months and mainly causes injection-site reactions like pain and swelling. Reyvow (lasmiditan) is a controlled substance due to its potential for abuse, whereas Ajovy (fremanezumab) is not. Both medications are only available as brand-name options, and neither has been studied in children under 18 years old.

  • Reyvow (lasmiditan)
    Ajovy (fremanezumab)
  • Reyvow (lasmiditan)
    Ajovy (fremanezumab)

  • Summary of Reyvow vs. Ajovy

    Summary for Serotonin agonist
    Prescription only

    Reyvow, the brand name for lasmiditan, is a serotonin agonist. It's used to treat migraine with or without aura in adults. It comes as a tablet that's taken by mouth when you have a migraine. Many people feel pain relief within 2 hours. Common side effects include dizziness, sleepiness, and a "pins-and-needles" feeling. Reyvow (lasmiditan) is a controlled substance because of the risk of misuse. Currently, Reyvow (lasmiditan) is a brand-name medication only; there's no generic yet.

    Summary for CGRP receptor blocker
    Prescription only

    Ajovy (fremanezumab or fremanezumab-vfrm) is an injection under the skin that helps prevent migraines in adults. This medication is convenient because it only needs to be used once every month or once every 3 months. The only observed side effects in clinical studies were injection-site reactions (e.g., pain, swelling, redness). Ajovy (fremanezumab) is available as a prefilled autoinjector pen and a prefilled syringe. It's currently only available as a brand-name medication; there's no generic yet.

  • Indications of Reyvow vs. Ajovy

    Indications for
    •Treatment of migraine attacks with or without aura in adults
    Indications for
    •Prevention of migraines in adults

  • Pros and Cons of Reyvow vs. Ajovy

    Pros and Const for Serotonin agonist
    Pros
    •Starts to work to relieve migraine pain within 2 hours
    •Can take with or without food
    •Available in 3 different strengths
    Cons
    •Might not work as well as triptans
    •Need to wait at least 8 hours before driving or operating machinery after taking the medication because it affects how well you can stay alert
    •Not used to prevent migraines
    Pros and Const for CGRP receptor blocker
    Pros
    •Taken only once per month or once every 3 months
    •Can store at room temperature for up to 7 days, if needed
    •Available as a prefilled syringe and a prefilled autoinjector
    •Manufacturer offers a savings program for certain people
    Cons
    •Might be difficult for some people to use properly
    •Only used for preventing migraines (not for treating a migraine attack)
    •Available as a brand-name medication only
    •Hasn't been studied in children younger than 18 years old

  • Common Side Effects of Reyvow vs. Ajovy

    Common Side Effects for
    •Dizziness (up to 17%)
    •Numbness or tingling feeling (up to 9%)
    •Sleepiness (up to 7%)
    •Tiredness (up to 6%)
    Common Side Effects for
    •Pain, swelling, or redness at the injection site (43-45%)

  • Warnings of Reyvow vs. Ajovy

    Common Side Effects for
    •Dizziness and sleepiness
    •Serotonin syndrome
    •Medication-overuse headache
    Common Side Effects for
    •Allergic reactions

  • Prices with our coupons for Reyvow vs. Ajovy

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