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Compare Ubrelvy vs. Rizatriptan

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ubrelvy (ubrogepant) and Maxalt (rizatriptan) are both medications used to treat migraine attacks with or without aura. However, they belong to different medication classes. Ubrelvy is a calcitonin gene-related peptide (CGRP) receptor blocker, while Maxalt is a triptan. Ubrelvy is taken orally in doses of 50 mg to 100 mg, with a maximum of 200 mg per day, and is not available in a generic form. Maxalt is available as a generic and comes in oral tablets and orally disintegrating tablets (ODT), with a typical adult dose of 5 mg to 10 mg and a maximum of 30 mg per day. Ubrelvy can cause side effects like nausea, sleepiness, and dry mouth, and it interacts with many medications, including certain antibiotics and seizure medications. Maxalt can cause dizziness, sleepiness, and heart-related side effects, and it interacts with antidepressants and other migraine medications. Additionally, Maxalt is approved for use in children ages 6 and older, while Ubrelvy is only for adults.

  • Ubrelvy (ubrogepant)
    Rizatriptan (Maxalt)
  • Ubrelvy (ubrogepant)
    Rizatriptan (Maxalt)

  • Summary of Ubrelvy vs. Rizatriptan

    Summary for Calcitonin gene-related peptide (CGRP) receptor antagonist
    Prescription only

    Ubrelvy (ubrogepant) is a migraine medication called a calcitonin gene-related peptide (CGRP) receptor antagonist. It can treat sudden migraine attacks in adults. Ubrelvy (ubrogepant) is a tablet you take by mouth. You take one dose when you feel a migraine starting. If needed, you can take a second dose at least 2 hours later. Your dose depends if Ubrelvy (ubrogepant) interacts with the other medications you take. Side effects include nausea and tiredness.

    Summary for Triptan
    Prescription only

    Rizatriptan (Maxalt) is used to treat migraines with or without aura in people ages 6 years and older. Rizatriptan (Maxalt) is available as a lower-cost generic tablet and an orally disintegrating tablet (ODT) that's placed on the tongue. Common side effects include dizziness, headache, and sleepiness. It can interact with antidepressants and other similar migraine medications.

  • Indications of Ubrelvy vs. Rizatriptan

    Indications for
    •Treatment of migraine attacks with or without aura in adults
    Indications for
    •Treatment of migraine attacks with or without aura in people ages 6 years and older

  • Pros and Cons of Ubrelvy vs. Rizatriptan

    Pros and Const for Calcitonin gene-related peptide (CGRP) receptor antagonist
    Pros
    •A tablet that's taken by mouth
    •Helps treat sudden migraine attacks
    •Good option when triptans like sumatriptan (Imitrex) haven't worked well
    Cons
    •Takes 1 to 2 hours to start working
    •Not for preventing migraines
    •Can interact with other medications, like verapamil and phenobarbital
    Pros and Const for Triptan
    Pros
    •First-choice option for treating migraines
    •Can be used by children ages 6 years and older
    •Orally disintegrating tablet (ODT) a possible option for people who have problems swallowing
    •Works within 30 minutes
    Cons
    •Can't use to prevent migraines
    •Is short-acting, so it might not last as long
    •Not clear if taking a second dose (adults only) is actually helpful
    •Your migraines can get worse if you use this medication too often.

  • Common Side Effects of Ubrelvy vs. Rizatriptan

    Common Side Effects for
    •Nausea (up to 4%)
    •Sleepiness (up to 3%)
    •Dry mouth (up to 2%)
    Common Side Effects for
    •Dizziness (4-9%)
    •Sleepiness (4-8%)
    •Tiredness (4-7%)
    •Nausea (4-6%)

  • Warnings of Ubrelvy vs. Rizatriptan

    Common Side Effects for
    •Allergic reactions
    •High blood pressure
    •Raynaud's phenomenon
    Common Side Effects for
    •Heart problems and high blood pressure
    •Stroke or other brain injury
    •Extreme narrowing of blood vessels
    •Taking too much rizatriptan (Maxalt)
    •Serotonin syndrome
    •Caution use in people with phenylketonuria (PKU) - orally disintegrating tablets only

  • Prices with our coupons for Ubrelvy vs. Rizatriptan

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