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Compare Ubrelvy vs. Ajovy

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Ubrelvy (ubrogepant)
    Ajovy (fremanezumab)
  • Ubrelvy (ubrogepant)
    Ajovy (fremanezumab)

  • Summary of Ubrelvy vs. Ajovy

    Summary for Calcitonin gene-related peptide (CGRP) receptor antagonist
    Prescription only

    Ubrelvy (ubrogepant) is a migraine medication called a calcitonin gene-related peptide (CGRP) receptor antagonist. It can treat sudden migraine attacks in adults. Ubrelvy (ubrogepant) is a tablet you take by mouth. You take one dose when you feel a migraine starting. If needed, you can take a second dose at least 2 hours later. Your dose depends if Ubrelvy (ubrogepant) interacts with the other medications you take. Side effects include nausea and tiredness.

    Summary for CGRP receptor blocker
    Prescription only

    Ajovy (fremanezumab or fremanezumab-vfrm) is an injection under the skin that helps prevent migraines in adults. This medication is convenient because it only needs to be used once every month or once every 3 months. The only observed side effects in clinical studies were injection-site reactions (e.g., pain, swelling, redness). Ajovy (fremanezumab) is available as a prefilled autoinjector pen and a prefilled syringe. It's currently only available as a brand-name medication; there's no generic yet.

  • Indications of Ubrelvy vs. Ajovy

    Indications for
    •Treatment of migraine attacks with or without aura in adults
    Indications for
    •Prevention of migraines in adults

  • Pros and Cons of Ubrelvy vs. Ajovy

    Pros and Const for Calcitonin gene-related peptide (CGRP) receptor antagonist
    Pros
    •A tablet that's taken by mouth
    •Helps treat sudden migraine attacks
    •Good option when triptans like sumatriptan (Imitrex) haven't worked well
    Cons
    •Takes 1 to 2 hours to start working
    •Not for preventing migraines
    •Can interact with other medications, like verapamil and phenobarbital
    Pros and Const for CGRP receptor blocker
    Pros
    •Taken only once per month or once every 3 months
    •Can store at room temperature for up to 7 days, if needed
    •Available as a prefilled syringe and a prefilled autoinjector
    •Manufacturer offers a savings program for certain people
    Cons
    •Might be difficult for some people to use properly
    •Only used for preventing migraines (not for treating a migraine attack)
    •Available as a brand-name medication only
    •Hasn't been studied in children younger than 18 years old

  • Common Side Effects of Ubrelvy vs. Ajovy

    Common Side Effects for
    •Nausea (up to 4%)
    •Sleepiness (up to 3%)
    •Dry mouth (up to 2%)
    Common Side Effects for
    •Pain, swelling, or redness at the injection site (43-45%)

  • Warnings of Ubrelvy vs. Ajovy

    Common Side Effects for
    •Allergic reactions
    •High blood pressure
    •Raynaud's phenomenon
    Common Side Effects for
    •Allergic reactions

  • Prices with our coupons for Ubrelvy vs. Ajovy

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