Ubrelvy (ubrogepant) is used to treat sudden migraine attacks in adults. Your provider will decide the dosage (50 mg or 100 mg) based on how well you respond to the medication, if you have kidney or liver problems, or if you're taking a medication that interacts with Ubrelvy (ubrogepant). Side effects include nausea, sleepiness, and dry mouth.
Migraine attacks with or without aura in adults
Ubrelvy (ubrogepant) is a calcitonin gene-related peptide (CGRP) receptor blocker. High levels of CGRP cause pain and inflammation, which commonly leads to migraines. Ubrelvy (ubrogepant) blocks CGRP to prevent it from causing pain and inflammation, which leads to relief of migraines.
Source: DailyMed
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
Can be taken with or without food
Can be used to treat sudden migraine attacks
Good option when triptan medications, such as sumatriptan (Imitrex) or rizatriptan (Maxalt), haven't worked to treat your migraines
Can't be used to prevent migraines
Must wait at least 2 hours after the first dose to take a second dose
Interacts with a lot of medications
Takes 1 to 2 hours to work
You can take Ubrelvy (ubrogepant) with or without food. But know that a high-fat meal can delay how quickly Ubrelvy (ubrogepant) works for you. If the medication is hurting your stomach, try taking it with food to help.
Ubrelvy (ubrogepant) isn't meant to be used to treat more than 8 migraines per month because it might not be safe to do so. If you have migraines multiple times a month, let your provider know. They can consider other medication options to help with your symptoms. Or they can let you know if you need to start any medications for migraine prevention.
Ubrelvy (ubrogepant) interacts with many medications. Depending on the situation, your healthcare provider might have to raise or lower your dose of Ubrelvy (ubrogepant) or the other medication that you're taking. Make sure to let your provider and pharmacist know about all the medications you're taking (including vitamins and supplements) before starting Ubrelvy (ubrogepant) so that they can help you check for interactions. If there are many interactions, your provider might even switch you to a different migraine medication.
Let your provider know if you eat grapefruit or drink grapefruit juice regularly. If so, they'll need to lower your dose of Ubrelvy (ubrogepant). This is because grapefruit can raise the amount of medication in your body, which puts you at higher risk for side effects like nausea and sleepiness.
Though not common, Ubrelvy (ubrogepant) can make you feel very sleepy. Don't drive or do anything that requires a lot of attention until you know how this medication affects you.
Store Ubrelvy (ubrogepant) at room temperature in a place out of reach from children at all times. If you or your child accidentally overdoses on Ubrelvy (ubrogepant), get emergency medical help or call your local poison control center at 1-800-222-1222 right away.
Ubrelvy (ubrogepant) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Severe allergic reactions to Ubrelvy (ubrogepant) are possible, including life-threatening reactions like facial swelling, shock, and anaphylaxis (closing of the throat). If you notice dizziness, a choking sensation, nausea, swelling around your eyes, swelling of the lips or tongue, or difficulty breathing after using Ubrelvy (ubrogepant), get medical attention right away.
The typical dose is 50 mg to 100 mg by mouth with or without food when you have a migraine attack. If your migraine doesn't go away, you can take a second dose at least 2 hours after your first dose. The maximum dose is 200 mg per day.
Your dose might differ if you have kidney problems, liver problems, or are taking a medication that interacts with Ubrelvy (ubrogepant).
Taking medications that strongly interact with Ubrelvy (ubrogepant), such as itraconazole (Sporanox and clarithromycin (Biaxin)
Migraine attacks with or without aura in adults
Treatment of migraine attacks with or without aura in adults
Prevention and treatment of migraines with or without aura in adults
By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.
Allergan, Inc. (2023). UBRELVY- ubrogepant tablet [package insert]. DailyMed.
Ubrelvy.com (n.d.). How does Ubrelvy work?
Ubrelvy.com (n.d.). Ubrelvy.
Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.