Key takeaways
Ajovy (fremanezumab) and Emgality (galcanezumab) are both medications used to prevent migraines, but they have some differences. Ajovy is a CGRP receptor blocker, while Emgality is a monoclonal antibody that blocks the CGRP ligand. Ajovy is available only as a brand-name medication and can be injected once a month or once every three months. Emgality, also a brand-name medication, is injected once monthly. Ajovy is used solely for migraine prevention, while Emgality can also treat episodic cluster headaches. Common side effects for Ajovy include injection-site reactions like pain and swelling, while Emgality can cause injection-site reactions, sore throat, and back pain. Both medications need to be stored in the refrigerator but can be kept at room temperature for up to 7 days.
