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Compare Emgality vs. Ubrelvy

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Emgality (galcanezumab) and Ubrelvy (ubrogepant) are both medications used to treat migraines, but they work in different ways and are used for different purposes. Emgality is a monoclonal antibody that prevents migraines and treats episodic cluster headaches by blocking the calcitonin gene-related peptide (CGRP) ligand. It is administered as a monthly subcutaneous injection. Ubrelvy, on the other hand, is a CGRP receptor blocker used to treat sudden migraine attacks in adults. It is taken orally, with a typical dose of 50 mg to 100 mg, and can be taken up to twice a day. Both are only available as brand-name medications. Common side effects of Emgality include injection site reactions and sore throat, while Ubrelvy may cause nausea, sleepiness, and dry mouth. Additionally, Ubrelvy has many drug interactions, so you should inform your prescriber about all medications you are taking. Emgality is not known to have many interactions but can cause serious allergic reactions.

  • Emgality (galcanezumab)
    Ubrelvy (ubrogepant)
  • Emgality (galcanezumab)
    Ubrelvy (ubrogepant)

  • Summary of Emgality vs. Ubrelvy

    Summary for CGRP antagonist
    Prescription only

    Emgality (galcanezumab or galcanezumab-gnlm) is an injectable medication that can help prevent migraine attacks in adults. It can also help treat cluster headaches in adults. This medication is a monoclonal antibody that works as a CGRP antagonist. It blocks the CGRP protein in the brain that can cause migraine and headache pain. Emgality (galcanezumab) comes as a prefilled pen and syringe. You inject one dose of the medication under the skin monthly. Some common side effects include pain, itching, and redness at the injection site.

    Summary for Calcitonin gene-related peptide (CGRP) receptor antagonist
    Prescription only

    Ubrelvy (ubrogepant) is a migraine medication called a calcitonin gene-related peptide (CGRP) receptor antagonist. It can treat sudden migraine attacks in adults. Ubrelvy (ubrogepant) is a tablet you take by mouth. You take one dose when you feel a migraine starting. If needed, you can take a second dose at least 2 hours later. Your dose depends if Ubrelvy (ubrogepant) interacts with the other medications you take. Side effects include nausea and tiredness.

  • Indications of Emgality vs. Ubrelvy

    Indications for
    •Prevention of migraines in adults
    •Treatment of episodic (occasional) cluster headaches in adults
    Indications for
    •Treatment of migraine attacks with or without aura in adults

  • Pros and Cons of Emgality vs. Ubrelvy

    Pros and Const for CGRP antagonist
    Pros
    •Only needs to be given once a month
    •Good option for people who have a hard time taking medications by mouth
    •Generally well tolerated
    Cons
    •Not a good option for people who don't like needles
    •Need to store in a refrigerator
    •Not known if the medication works well or is safe in children, during pregnancy, or while breastfeeding
    Pros and Const for Calcitonin gene-related peptide (CGRP) receptor antagonist
    Pros
    •A tablet that's taken by mouth
    •Helps treat sudden migraine attacks
    •Good option when triptans like sumatriptan (Imitrex) haven't worked well
    Cons
    •Takes 1 to 2 hours to start working
    •Not for preventing migraines
    •Can interact with other medications, like verapamil and phenobarbital

  • Common Side Effects of Emgality vs. Ubrelvy

    Common Side Effects for
    •Pain, itching, warmth, and other injection site reactions (18%)
    Common Side Effects for
    •Nausea (up to 4%)
    •Sleepiness (up to 3%)
    •Dry mouth (up to 2%)

  • Warnings of Emgality vs. Ubrelvy

    Common Side Effects for
    •Serious allergic reactions
    •High blood pressure
    •Raynaud's phenomenon
    Common Side Effects for
    •Allergic reactions
    •High blood pressure
    •Raynaud's phenomenon

  • Prices with our coupons for Emgality vs. Ubrelvy

    Learn more about Emgality
    Learn more about Ubrelvy

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