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Aimovig

erenumab
Used for Migraine
Used for Migraine

Aimovig (erenumab or erenumab-aooe) is a medication that's used to prevent migraines in adults. It's convenient because it's available as a prefilled autoinjector or syringe, but it's important that you know how to inject the medication properly for it to work. Aimovig (erenumab) is available as a brand-name medication only and is given as an injection under your skin once a month. Possible side effects include pain, swelling, or redness at the injection site and constipation.

Last reviewed on April 27, 2023
basics-icon

What is Aimovig (erenumab)?

What is Aimovig (erenumab) used for?

How Aimovig (erenumab) works

Aimovig (erenumab) is a monoclonal antibody that blocks proteins in the brain and nervous system called calcitonin gene-related peptide (CGRP) receptors. These proteins are thought to have a role in pain signaling and migraine symptoms. By blocking CGRP receptors, Aimovig (erenumab) might help prevent migraines.

Drug Facts

Common BrandsAimovig
Drug ClassCGRP receptor antagonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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$690.00
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What are the side effects of Aimovig (erenumab)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Pain, swelling, or redness at the injection site (5-6%)
  • Constipation (1-3%)

Other Side Effects

  • Muscle cramps or spasms
  • Skin rash
  • Hair loss
  • Mouth ulcer

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reactions: hives, itching, swelling of face or tongue, difficulty breathing
  • Extremely high blood pressure: headache, nosebleed, fatigue, vision problems

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
  • Constipation, bloating, nausea or vomiting, stomach pain, which may be signs of slow movement through the digestive tract
  • Increase in blood pressure
  • Raynaud syndrome—cool, numb, or painful fingers or toes that may change color from pale, to blue, to red

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Aimovig (erenumab)

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Pros

Taken only once per month

Can store at room temperature for up to 7 days, if needed (though typically refrigerated)

Available as a prefilled syringe and a prefilled autoinjector

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Cons

Must give as an injection under the skin

Can't use in children

Some autoinjectors and syringes might have parts that are made with dry natural rubber, which can cause allergic reactions in people sensitive to latex.

pharmacist-tips

Pharmacist tips for Aimovig (erenumab)

pharmacist
  • You should receive training from your provider or pharmacist on how to give yourself Aimovig (erenumab). Make sure you know how to inject the medication to avoid accidentally hurting yourself or wasting the medication. Read the instructions for use for the 70 mg/mL autoinjector, 140 mg/mL autoinjector, or the prefilled syringe. Contact your pharmacist or provider if you have any questions.

    • Inject Aimovig (erenumab) under the skin into the fatty tissue of your thighs, stomach, or back of your upper arms. Never inject it into your muscle or vein.

      • Inject Aimovig (erenumab) one time per month. If you forget to take your dose at the time you normally do, inject the medication as soon as you remember. Then, continue to take Aimovig (erenumab) each month from the date of your last dose.

        • Keep Aimovig (erenumab) in the carton it comes in to protect it from light. Store it in the refrigerator, but don't freeze it. If needed, you can keep Aimovig (erenumab) at room temperature for up to 7 days. This might be helpful if you're traveling and don't have access to a refrigerator. But make sure that you don't put Aimovig (erenumab) back in the refrigerator after it's reached room temperature and throw away any medication that's been at room temperature for more than 7 days.

          • Before you take your Aimovig (erenumab) dose, take the medication out of the refrigerator and lay it on a flat surface to warm up for at least 30 minutes. Don't shake it or warm it up any other way since this can damage the medication.

            • Always check the medication solution to make sure it's either clear and colorless or slightly yellow before using it. If it's cloudy, discolored, or has particles (chunks), don't use it. Additionally, don't use Aimovig (erenumab) if any part of the syringe or autoinjector is broken, if it was dropped on the floor, or if the cap is missing. Otherwise, the medication might not be safe to use. Use a new syringe or autoinjector, and call the manufacturer at 1-800-772-6436 for a replacement.

              • Each Aimovig (erenumab) autoinjector or syringe provides a single dose of medication. After using each autoinjector or syringe, throw it away, even if there's still some medication left inside. Any leftover medication won't be enough for another full dose, and there aren't any preservatives to keep germs out of the medication once you open it.

                • Throw away the Aimovig (erenumab) autoinjector or syringe in a sharps container or something made of heavy-duty plastic, such as an empty milk carton or laundry detergent bottle. Don't throw away needles or syringes in your trash can. These steps help lower the risk of needlestick injuries. For more information on how to throw away your sharps container safely and guidance for your specific state, visit the FDA's website.

                  More on Aimovig (erenumab) tips

                  faqs

                  Frequently asked questions about Aimovig (erenumab)

                  How long does Aimovig (erenumab) take to work?
                  Studies showed that Aimovig (erenumab) can start to work within 3 months to lower the number of migraines you have. But keep in mind that how quickly the medication starts to work can be different for everyone. The American Headache Society recommends trying Aimovig (erenumab) for at least 3 months before seeing how well it's working for you to prevent migraines. Make sure to continue using the medication even if you don't feel a difference. If you've been using Aimovig (erenumab) for at least 3 months and still don't feel that it's helping to prevent migraines, talk to your provider.
                  How well does Aimovig (erenumab) work?
                  In studies, people with chronic migraines (having 15 or more headache days per month) had an average of about 7 fewer migraine days per month after taking Aimovig (erenumab) for 3 months. Participants with episodic migraines (having 4 to 14 migraine days per month) had an average of 3 to 4 fewer migraine days per month after taking Aimovig (erenumab) for 6 months. After taking Aimovig (erenumab) for a few months, make sure to follow up with your provider about how the medication is working for you.
                  How do I inject Aimovig (erenumab)?
                  Your provider will review how to inject Aimovig (erenumab) properly. You can also read the instructions for use for the 70 mg/mL autoinjector, 140 mg/mL autoinjector, or the prefilled syringe. You'll inject Aimovig (erenumab) under the skin of your thighs, stomach (at least 2 inches away from the belly button), or back of your upper arms. Avoid raised, thick, red, scaly, or scarred skin with patches, lesions, or stretch marks to prevent pain or skin damage. In general, for the autoinjector, inject the medication at a 90 degree angle into a stretched or pinched area of skin. And for the syringe, inject the medication at a 45 to 90 degree angle into a pinched area of skin. Make sure to switch injection sites for each dose to lower the risk of bruising and skin irritation. Ask your pharmacist or provider if you have any questions about how to inject Aimovig (erenumab).
                  Does Aimovig (erenumab) cause weight gain?
                  In studies, participants didn't report weight gain as a side effect while they were taking Aimovig (erenumab). If you notice unusual changes in weight while taking Aimovig (erenumab), it's best to speak with your provider. They'll check to see if there's something going on.
                  Can my child use Aimovig (erenumab)?
                  It's not known if Aimovig (erenumab) is safe or works well in children younger than 18 years old. If your child has migraines, ask your child's provider for other available preventative and treatment options.
                  Is Aimovig (erenumab) safe to use if I'm pregnant?
                  There haven't been enough studies looking at how safe Aimovig (erenumab) is for pregnant women and their babies. There was one study about a mother who took Aimovig (erenumab) during pregnancy, which didn't appear to harm the baby. In studies done on animals, Aimovig (erenumab) didn't cause any harm to their unborn babies. But more research needs to be done to know for sure whether taking Aimovig (erenumab) during pregnancy is safe for you and your baby. If you're pregnant or thinking of getting pregnant, talk to your provider to see if Aimovig (erenumab) is right for you. If you're pregnant and are prescribed Aimovig (erenumab), it's recommended that you enroll in the GENESIS pregnancy registry. This program keeps track of your and your baby's health during and after treatment if you take Aimovig (erenumab) while pregnant.
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                  What are the risks and warnings for Aimovig (erenumab)?

                  Aimovig (erenumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                  risk-warning

                  Allergic reaction

                  • Risk factors: Known latex or rubber allergy

                    It's possible to have an allergic reaction to Aimovig (erenumab). These allergic reactions are typically mild and might look like an itchy rash on the skin. They can happen within hours of taking the medication, but can sometimes show up more than a week after your dose.

                    Some Aimovig (erenumab) prefilled autoinjectors and prefilled syringes have certain parts that are made with dry natural rubber. If you're allergic to latex or rubber, using these particular Aimovig (erenumab) prefilled autoinjectors and prefilled syringes can cause an allergic reaction. Let your provider know if you're allergic to latex and what your reaction to latex is.

                    If you have a serious or severe allergic reaction (e.g., hives, swelling of face or tongue, difficulty breathing) while taking Aimovig (erenumab), stop taking the medication and get medical help right away.

                    risk-warning

                    Constipation with serious complications

                    • Risk factors: Taking other medications that worsen constipation

                      Aimovig (erenumab) can cause constipation with serious complications that can sometimes require hospitalization or even surgery. In the majority of cases that happened during clinical studies, constipation started after the first dose of Aimovig (erenumab). But it's possible to have constipation later on in treatment as well. The risk for severe constipation and its complications might be higher if you're taking other medications that cause constipation. If you get constipated while using Aimovig (erenumab), contact your provider.

                      risk-warning

                      High blood pressure

                      • Risk factors: History of high blood pressure

                        Aimovig (erenumab) can cause new or worsening high blood pressure. You're at risk if you already have high blood pressure or if you have risk factors for high blood pressure. Some people who experienced high blood pressure during Aimovig (erenumab) treatment needed to take blood pressure medications. And in some cases, elevations in blood pressure even led to hospitalization. While high blood pressure can happen anytime during treatment, it's more common to happen within a week of taking your Aimovig (erenumab) dose, particularly after your first dose. If you notice any symptoms of extremely high blood pressure (e.g., headache, chest pain, nosebleed, vision problems), call 911 right away.

                        dosage

                        Aimovig (erenumab) dosage forms

                        The average cost for 1 sureclick of 140mg/ml of Aimovig (erenumab) is $749.61 with a free GoodRx coupon. This is 18.62% off the average retail price of $921.09.
                        carton
                        Carton
                        DosageQuantityPrice as low asPrice per unit
                        2 sureclicks of 70mg/ml1 carton$690.00$690.00
                        sureclick
                        Sureclick
                        DosageQuantityPrice as low asPrice per unit
                        70mg/ml1 sureclick$737.69$737.69
                        140mg/ml1 sureclick$749.61$749.61

                        Typical dosing for Aimovig (erenumab)

                        The typical dose is 70 mg injected under the skin once per month. Your provider might raise your dose to 140 mg once per month depending on how you respond to the medication.

                        More on Aimovig (erenumab) dosage forms

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                        What are alternatives to Aimovig (erenumab)?

                        There are a number of medications that your doctor can prescribe in place of Aimovig (erenumab). Compare a few possible alternatives below.
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                        latest news

                        What is the latest news about Aimovig (erenumab)?

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                        Aimovig (erenumab) images

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                        References

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