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Compare Daxxify vs. Botox

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Daxxify (daxibotulinumtoxinA) and Botox (onabotulinumtoxinA) are both neuromuscular blockers used to treat neck spasms (cervical dystonia) and improve the appearance of frown lines. However, they differ in several ways. Daxxify is specifically FDA-approved for frown lines and neck spasms, while Botox has a broader range of FDA-approved uses, including overactive bladder, headache prevention, and excessive sweating. Daxxify is typically injected into the muscles with doses of 40 units for frown lines and 125 to 250 units for neck spasms, whereas Botox's dosing varies based on the condition being treated. Both medications are available only as brand-name injections administered by healthcare professionals. Common side effects of Daxxify include headache and injection site reactions, while Botox can cause urinary tract infections and neck pain, among others. Both medications carry risks of serious side effects if the toxin spreads beyond the injection site.

Daxxify
Botox (onabotulinumtoxinA)
Daxxify
Botox (onabotulinumtoxinA)
Summary of Daxxify vs. Botox
Summary for Neuromuscular blocker
Prescription only
Daxxify (daxibotulinumtoxinA or daxibotulinumtoxinA-lanm) is an FDA-approved medication for adults to temporarily improve the appearance of frown lines (wrinkles between your eyebrows and in your forehead). It's also used to treat cervical dystonia (muscle spasms in the neck). This medication is injected into the muscles by a trained healthcare provider. Common side effects include headache and pain at the injection site. Daxxify seems to last longer than other botulinum toxin injections (e.g., Botox).
Summary for Neuromuscular blocker
Prescription only
Botox (onabotulinumtoxinA) is a prescription injection used for many medical conditions caused by muscle overactivity or nerve problems. It's FDA approved for treating conditions like overactive bladder, excessive armpit sweating, and for preventing migraines. The medication is injected by a trained healthcare professional. Side effects depend on where the injection is given, but they can include urinary tract infections, headache, and neck pain. <br> Botox (onabotulinumtoxinA) is different from Botox Cosmetic, which is used for facial and neck lines.
Indications of Daxxify vs. Botox
Indications for

•Temporary improvement in the appearance of moderate-to-severe frown lines (glabellar lines) in adults

•Neck spasms (cervical dystonia) in adults

Indications for

•Overactive bladder (OAB) - adults

•Loss of bladder control caused by nerve-bladder problems - adults

•Nerve-related bladder problem - children 5 years and older

•Headache prevention for chronic migraine - adults

•Muscle spasms - adults and children 2 years and older

•Neck muscle spasms - adults

•Excessive armpit sweating - adults

•Eyelid twitching - adults and children 12 years and older

•Crossed eyes - adults and children 12 years and older
Pros and Cons of Daxxify vs. Botox
Pros and Const for Neuromuscular blocker
Pros

•Works well to improve the look of frown lines

•Can last for up to 6 months or longer for moderate-to-severe frown lines

•Injected directly into the muscles causing your condition to help them relax

•Given by a trained healthcare provider

Cons

•Injections can be painful

•Can cause headache and muscle weakness

•Requires repeat injections since effects are temporary

•Brand only

Pros and Const for Neuromuscular blocker
Pros

•FDA approved to treat many different conditions

•Might be a good option when other treatments have failed

•Injected directly into the area causing trouble

•Effects last a few months

Cons

•Needs to be injected by a healthcare professional

•Injections can be uncomfortable

•Has serious risks if the toxin spreads to other parts of your body

•Might need to get repeat treatments
Common Side Effects of Daxxify vs. Botox
Common Side Effects for
Frown lines

•Headache (6%)

•Injection site reactions (e.g., pain, redness, swelling; 6%)

•Drooping eyelids (2%)

•Trouble moving parts of the face (1%)

Cervical dystonia

•Headache (7-9%)

•Injection site reactions (e.g., pain, redness; up to 8%)

•Upper respiratory tract infection (up to 5%)

•Muscle weakness (2-5%)

•Muscle and bone pain (4%)

•Trouble swallowing (2-4%)

•Spine pain (2-3%)

Common Side Effects for
Overactive bladder:

•Urinary tract infection (18%)

•Painful urination (9%)

•Trouble emptying the bladder (6%)

Loss of bladder control:

•Urinary tract infection (24-26%)

•Urine left in the bladder (17%)

•Trouble emptying the bladder (15-17%)

•Difficulty passing urine (15%)

Chronic migraine:

•Neck pain (9%)

•Headache (5%)

Muscle spasms:

•Pain in the arm or leg (up to 9%)

•Muscle weakness (up to 4%)

Neck muscle spasm:

•Trouble swallowing (19%)

•Upper respiratory infection (12%)

•Neck pain (11%)

•Headache (11%)

Excessive armpit sweating:

•Injection site pain (3-10%)

•Bleeding (3-10%)

•Infection (3-10%)

Eyelid twitching:

•Droopy eyelid (21%)

•Damage to surface of the eye (6%)

•Dry eye (6%)

Crossed eyes:

•Droopy eyelid (1-38%)

•Eye misalignment (17%)
Warnings of Daxxify vs. Botox
Common Side Effects for

•Spread of toxin effects

•Allergic reaction

•Worsening of certain conditions

•Difficulty swallowing or breathing

•Reduced blinking, dry eye, and vision changes (when used for frown lines)

Common Side Effects for

•Spread of toxin effect

•Serious allergic reaction

•Difficulty swallowing or breathing

•Lung problems in people with breathing conditions

•Eye problems and bleeding

•Bronchitis and upper respiratory tract infections

•Overactive nervous system

•Urinary tract infections

•Trouble emptying the bladder

•Transmission of diseases
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Compare Daxxify vs. Botox

Key takeaways

Summary of Daxxify vs. Botox

Indications of Daxxify vs. Botox

Pros and Cons of Daxxify vs. Botox

Common Side Effects of Daxxify vs. Botox

Warnings of Daxxify vs. Botox

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