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Compare Vyepti vs. Botox

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Vyepti (eptinezumab) and Botox (onabotulinumtoxinA) are both used to prevent migraines, but they work in different ways and have different uses. Vyepti is a CGRP receptor blocker given as an IV infusion every 3 months, while Botox is a neuromuscular blocker injected into muscles every 3 months. Vyepti is only used for migraine prevention, whereas Botox is also used for various conditions like overactive bladder, muscle spasms, and excessive sweating. Vyepti's side effects are generally mild, such as common cold symptoms and itching, while Botox can cause more serious side effects like trouble breathing or swallowing if the toxin spreads. Additionally, both medications are only available as a brand name and require administration by a healthcare professional, but Vyepti involves a 30-minute infusion, whereas Botox injections are quicker, taking about 10 to 20 minutes.

  • Vyepti (eptinezumab)
    Botox (onabotulinumtoxinA)
  • Vyepti (eptinezumab)
    Botox (onabotulinumtoxinA)

  • Summary of Vyepti vs. Botox

    Summary for CGRP receptor blocker
    Prescription only

    Vyepti (eptinezumab or eptinezumab-jjmr) is a medication that's used to prevent migraines in adults. The dose is given as an infusion through the veins at a provider's office or clinic every 3 months. Side effects aren't common, but they can include common cold symptoms, itching, and flushing. Vyepti (eptinezumab) is only available as a brand name.

    Summary for Neuromuscular blocker
    Prescription only

    Botox (onabotulinumtoxinA) is used for many movement problems, bladder problems, and headache prevention, but it can have dangerous side effects if it spreads to areas outside of the injection area. It's only available as an injection that's administered by a healthcare provider.

  • Indications of Vyepti vs. Botox

    Indications for
    •Prevention of migraines in adults
    Indications for
    •Overactive bladder (OAB) in adults
    •Loss of bladder control due to nerve problems in people 5 years and older
    •Headache prevention in adults with long-term migraine (headaches lasting 4 hours or longer for 15 or more days per month)
    •Muscle spasms in people 2 years and older
    •Neck spasms in adults
    •Excessive armpit sweating in adults
    •Eyelid twitching in people 12 years and older
    •Crossed eyes in people 12 years and older

  • Pros and Cons of Vyepti vs. Botox

    Pros and Const for CGRP receptor blocker
    Pros
    •Works well to lower the number of migraines you get
    •Taken only every 3 months
    •Few side effects
    Cons
    •Given as an infusion through the veins (IV)
    •Needs to be given by a healthcare provider
    •Hasn't been studied well enough in children or in older adults, so it's not completely known how well the medication works for them
    Pros and Const for Neuromuscular blocker
    Pros
    •Works well to treat and prevent many different conditions
    •Might be a good option when other treatments have failed
    •Injected directly into the affected area(s)
    •Effects can last many weeks or even months
    Cons
    •Needs to be injected by a healthcare provider
    •Injections can be uncomfortable
    •Has serious risks if the toxin spreads to other parts of your body
    •Brand only, so might be expensive

  • Common Side Effects of Vyepti vs. Botox

    Common Side Effects for
    •Common cold symptoms (6-8%)
    Common Side Effects for

    OAB

    •Urinary tract infection (UTI, 18%)
    •Painful urination (9%)
    •Difficulty passing urine (6%)

    Loss of bladder control

    •Urinary tract infection (UTI, 24-26% in adults, 7% in children)
    •Urine left in bladder (17% in adults)
    •Difficulty passing urine (15-17% in adults)
    •Bacteria in urine (9% in adults, 20% in children)
    •White blood cells in urine (7% in children)
    •Painful urination (5% in adults)

    Migraine prevention in adults

    •Neck pain (9%)
    •Headache (5%)

    ^*Not a comprehensive list of side effects, as they vary depending on the condition you have. Refer to the source below for more details.^

  • Warnings of Vyepti vs. Botox

    Common Side Effects for
    •Allergic reactions
    Common Side Effects for
    •Spread of toxin effects
    •Serious allergic reaction
    •Higher risk of side effects
    •Difficulty swallowing or breathing
    •Reduced blinking and eye bleeding
    •Abnormal overreaction of your nervous system (autonomic dysreflexia)
    •Higher risk of urinary tract infections (UTI) and trouble urinating (urinary retention)

  • Prices with our coupons for Vyepti vs. Botox

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    Learn more about Botox

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