Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Vyepti vs. Botox

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Vyepti (eptinezumab) and Botox (onabotulinumtoxinA) are both used to prevent migraines, but they work in different ways and have different uses. Vyepti is a CGRP receptor blocker given as an IV infusion every 3 months, while Botox is a neuromuscular blocker injected into muscles every 3 months. Vyepti is only used for migraine prevention, whereas Botox is also used for various conditions like overactive bladder, muscle spasms, and excessive sweating. Vyepti's side effects are generally mild, such as common cold symptoms and itching, while Botox can cause more serious side effects like trouble breathing or swallowing if the toxin spreads. Additionally, both medications are only available as a brand name and require administration by a healthcare professional, but Vyepti involves a 30-minute infusion, whereas Botox injections are quicker, taking about 10 to 20 minutes.

  • Vyepti (eptinezumab)
    Botox (onabotulinumtoxinA)
  • Vyepti (eptinezumab)
    Botox (onabotulinumtoxinA)

  • Summary of Vyepti vs. Botox

    Summary for CGRP receptor blocker
    Prescription only

    Vyepti (eptinezumab or eptinezumab-jjmr) is a medication that's used to prevent migraines in adults. The dose is given as an infusion through the veins at a provider's office or clinic every 3 months. Side effects aren't common, but they can include common cold symptoms, itching, and flushing. Vyepti (eptinezumab) is only available as a brand name.

    Summary for Neuromuscular blocker
    Prescription only

    Botox (onabotulinumtoxinA) is a prescription injection used for many medical conditions caused by muscle overactivity or nerve problems. It's FDA approved for treating conditions like overactive bladder, excessive armpit sweating, and for preventing migraines. The medication is injected by a trained healthcare professional. Side effects depend on where the injection is given, but they can include urinary tract infections, headache, and neck pain. <br> Botox (onabotulinumtoxinA) is different from Botox Cosmetic, which is used for facial and neck lines.

  • Indications of Vyepti vs. Botox

    Indications for
    •Prevention of migraines in adults
    Indications for
    •Overactive bladder (OAB) - adults
    •Loss of bladder control caused by nerve-bladder problems - adults
    •Nerve-related bladder problem - children 5 years and older
    •Headache prevention for chronic migraine - adults
    •Muscle spasms - adults and children 2 years and older
    •Neck muscle spasms - adults
    •Excessive armpit sweating - adults
    •Eyelid twitching - adults and children 12 years and older
    •Crossed eyes - adults and children 12 years and older

  • Pros and Cons of Vyepti vs. Botox

    Pros and Const for CGRP receptor blocker
    Pros
    •Works well to lower the number of migraines you get
    •Taken only every 3 months
    •Few side effects
    Cons
    •Given as an infusion through the veins (IV)
    •Needs to be given by a healthcare provider
    •Hasn't been studied well enough in children or in older adults, so it's not completely known how well the medication works for them
    Pros and Const for Neuromuscular blocker
    Pros
    •FDA approved to treat many different conditions
    •Might be a good option when other treatments have failed
    •Injected directly into the area causing trouble
    •Effects last a few months
    Cons
    •Needs to be injected by a healthcare professional
    •Injections can be uncomfortable
    •Has serious risks if the toxin spreads to other parts of your body
    •Might need to get repeat treatments

  • Common Side Effects of Vyepti vs. Botox

    Common Side Effects for
    •Common cold symptoms (6-8%)
    Common Side Effects for

    Overactive bladder:

    •Urinary tract infection (18%)
    •Painful urination (9%)
    •Trouble emptying the bladder (6%)

    Loss of bladder control:

    •Urinary tract infection (24-26%)
    •Urine left in the bladder (17%)
    •Trouble emptying the bladder (15-17%)
    •Difficulty passing urine (15%)

    Chronic migraine:

    •Neck pain (9%)
    •Headache (5%)

    Muscle spasms:

    •Pain in the arm or leg (up to 9%)
    •Muscle weakness (up to 4%)

    Neck muscle spasm:

    •Trouble swallowing (19%)
    •Upper respiratory infection (12%)
    •Neck pain (11%)
    •Headache (11%)

    Excessive armpit sweating:

    •Injection site pain (3-10%)
    •Bleeding (3-10%)
    •Infection (3-10%)

    Eyelid twitching:

    •Droopy eyelid (21%)
    •Damage to surface of the eye (6%)
    •Dry eye (6%)

    Crossed eyes:

    •Droopy eyelid (1-38%)
    •Eye misalignment (17%)

  • Warnings of Vyepti vs. Botox

    Common Side Effects for
    •Allergic reactions
    Common Side Effects for
    •Spread of toxin effect
    •Serious allergic reaction
    •Difficulty swallowing or breathing
    •Lung problems in people with breathing conditions
    •Eye problems and bleeding
    •Bronchitis and upper respiratory tract infections
    •Overactive nervous system
    •Urinary tract infections
    •Trouble emptying the bladder
    •Transmission of diseases

  • Prices with our coupons for Vyepti vs. Botox

    Learn more about Vyepti
    Learn more about Botox

Compare other Migraine drugs

Vyepti vs BotoxVyepti vs ZomigAimovig vs BotoxAmerge vs CafergotAmerge vs MigergotAmerge vs MigranalAmerge vs ZomigBotox Cosmetic vs DaxxifyBotox Cosmetic vs JeuveauDaxxify vs BotoxDysport vs BotoxEmgality vs ZomigFioricet vs ZomigFiorinal vs AxertFiorinal vs FrovaFiorinal vs ImitrexFiorinal vs RelpaxFiorinal vs ZomigFrova vs AmergeFrova vs ZomigJeuveau vs BotoxMaxalt vs ZomigQbrexza vs BotoxRelpax vs ZomigTretinoin vs BotoxXeomin vs BotoxZomig vs AxertZomig vs CafergotZomig vs ErgotamineZomig vs Imitrex
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.