Key takeaways
Zolmitriptan (Zomig) and ergotamine (Ergomar) are both prescription medications used to treat migraines, but they have some key differences. Zolmitriptan is a triptan that works by attaching to serotonin receptors to reduce blood vessel swelling and stop pain signals. It comes in various forms, including tablets, orally disintegrating tablets, and nasal spray. It's typically taken at the first sign of a migraine. On the other hand, ergotamine is an ergot derivative that tightens blood vessels and calms parts of the brain. It's taken sublingually (under the tongue) and is not usually a first-choice treatment. Ergomar is also used for cluster headaches, while Zomig is not. Zomig can cause side effects like dizziness and chest pain, whereas Ergomar can cause nausea and vomiting. Additionally, Ergomar has a longer-lasting effect but works slower than Zomig. Both medications should not be used frequently to avoid rebound headaches and other serious side effects.
