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Compare Vyepti vs. Zomig

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Vyepti (eptinezumab) and zolmitriptan (Zomig) are both used to manage migraines, but they work differently and are used in different ways. Vyepti is a CGRP receptor blocker given as an intravenous infusion every three months to prevent migraines. On the other hand, zolmitriptan is a triptan that you take at the first sign of a migraine to relieve pain. It comes in various forms, including tablets, orally disintegrating tablets, and a nasal spray. Vyepti is administered by a healthcare professional, while you can take zolmitriptan yourself at home. Vyepti is used for prevention of migraines, whereas zolmitriptan is used for immediate relief of migraines. Side effects for Vyepti are generally mild, like common cold symptoms, while zolmitriptan can cause dizziness, chest pain, and other more serious side effects, like irregular heart rhythm. Both medications are only available as brand-name.

  • Vyepti (eptinezumab)
    Zolmitriptan (Zomig)
  • Vyepti (eptinezumab)
    Zolmitriptan (Zomig)

  • Summary of Vyepti vs. Zomig

    Summary for CGRP receptor blocker
    Prescription only

    Vyepti (eptinezumab or eptinezumab-jjmr) is a medication that's used to prevent migraines in adults. The dose is given as an infusion through the veins at a provider's office or clinic every 3 months. Side effects aren't common, but they can include common cold symptoms, itching, and flushing. Vyepti (eptinezumab) is only available as a brand name.

    Summary for Triptan
    Prescription only

    Zolmitriptan (Zomig) is used for the short-term treatment of migraines. You typically take just one dose when you have a migraine. Zolmitriptan (Zomig) can cause side effects like dizziness and chest, neck, or jaw pain. This medication is a tablet that you swallow. It also comes as an orally disintegrating tablet (ODT) and a nasal spray, which can be good options for people who have trouble swallowing pills during a migraine. Zolmitriptan (Zomig) is available by prescription only as a brand-name and generic medication; it's not found over the counter.

  • Indications of Vyepti vs. Zomig

    Indications for
    •Prevention of migraines in adults
    Indications for
    •Treatment of migraine

  • Pros and Cons of Vyepti vs. Zomig

    Pros and Const for CGRP receptor blocker
    Pros
    •Works well to lower the number of migraines you get
    •Taken only every 3 months
    •Few side effects
    Cons
    •Given as an infusion through the veins (IV)
    •Needs to be given by a healthcare provider
    •Hasn't been studied well enough in children or in older adults, so it's not completely known how well the medication works for them
    Pros and Const for Triptan
    Pros
    •One of the first-choice options for adults to treat moderate or severe migraine
    •Works within 2 hours after taking the dose
    •Has ODT and nasal spray forms, so it's a good option for people who have trouble swallowing pills during a migraine
    Cons
    •Not used for other types of headaches
    •Doesn't prevent migraines from happening
    •Can worsen your headaches if you take the medication for more than 9 days in a month

  • Common Side Effects of Vyepti vs. Zomig

    Common Side Effects for
    •Common cold symptoms (6-8%)
    Common Side Effects for

    Tablets and orally disintegrating tablets

    •Nausea (up to 9%)
    •Dizziness (up to 8%)
    •Pins and needles feeling in the arms or legs (up to 7%)
    •Neck, throat, or jaw pain, tightness, or pressure (up to 7%)
    •Sleepiness (up to 6%)
    •Feeling warm or cold (up to 6%)
    •Body weakness (up to 5%)
    •Dry mouth (up to 5%)
    •Chest pain, tightness, pressure, or heaviness (up to 3%)

    Nasal spray

    •Unusual taste (up to 17%)
    •Dizziness (6%)
    •Pins and needles feeling in your arms or legs (5%)
    •Throat pain (4%)
    •Feeling warm (4%)
    •Dry mouth (3%)
    •Body weakness (3%)

  • Warnings of Vyepti vs. Zomig

    Common Side Effects for
    •Allergic reactions
    Common Side Effects for
    •Heart attack and chest pain (angina)
    •Irregular heart rhythm (arrhythmias)
    •Stroke or other brain injury
    •Blood vessel issues
    •Serotonin syndrome
    •High blood pressure
    •Caution use in people with phenylketonuria (PKU) - for orally disintegrating tablet only

  • Prices with our coupons for Vyepti vs. Zomig

    Learn more about Vyepti
    Learn more about Zolmitriptan

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