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Compare Qbrexza vs. Botox

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Qbrexza (glycopyrronium) and Botox (onabotulinumtoxinA) are both used to treat excessive underarm sweating, but they have some key differences. Qbrexza is an anticholinergic medication that you apply topically to your underarms using a towelette, while Botox is a neuromuscular blocker that must be injected by a healthcare professional. You use Qbrexza once every 24 hours. In contrast, Botox is typically administered every three months. Qbrexza is only available as a brand-name medication and can be expensive, whereas Botox is also brand-only and might be costly. Additionally, Botox has a broader range of uses, including treating muscle spasms, bladder problems, and preventing migraines, while Qbrexza is only approved for underarm sweating. Both medications have side effects, but Botox can have serious risks if the toxin spreads to other parts of your body.

  • Qbrexza (glycopyrronium)
    Botox (onabotulinumtoxinA)
  • Qbrexza (glycopyrronium)
    Botox (onabotulinumtoxinA)

  • Summary of Qbrexza vs. Botox

    Summary for Anticholinergic
    Prescription only

    Qbrexza (glycopyrronium) is an anticholinergic medication used to treat excessive underarm sweating, also known as primary axillary hyperhidrosis, in people 9 years and older. It's available as a cloth that you use once a day to wipe both of your underarms. Common side effects include dry mouth, blurry vision, and constipation. The medication is only available under brand name Qbrexza, as a generic version isn't available.

    Summary for Neuromuscular blocker
    Prescription only

    Botox (onabotulinumtoxinA) is used for many movement problems, bladder problems, and headache prevention, but it can have dangerous side effects if it spreads to areas outside of the injection area. It's only available as an injection that's administered by a healthcare provider.

  • Indications of Qbrexza vs. Botox

    Indications for
    •Excessive underarm sweating (primary axillary hyperhidrosis)
    Indications for
    •Overactive bladder (OAB) in adults
    •Loss of bladder control due to nerve problems in people 5 years and older
    •Headache prevention in adults with long-term migraine (headaches lasting 4 hours or longer for 15 or more days per month)
    •Muscle spasms in people 2 years and older
    •Neck spasms in adults
    •Excessive armpit sweating in adults
    •Eyelid twitching in people 12 years and older
    •Crossed eyes in people 12 years and older

  • Pros and Cons of Qbrexza vs. Botox

    Pros and Const for Anticholinergic
    Pros
    •Is a first-choice option to treat excessive underarm sweating
    •Applied to the underarms, directly targeting the sweat glands
    •Only need to apply once a day, every 24 hours
    Cons
    •Can cause problems urinating and blurred vision
    •Interacts with other anticholinergic medications
    •Risk of accidental exposure to others, especially children, leading to unwanted side effects
    Pros and Const for Neuromuscular blocker
    Pros
    •Works well to treat and prevent many different conditions
    •Might be a good option when other treatments have failed
    •Injected directly into the affected area(s)
    •Effects can last many weeks or even months
    Cons
    •Needs to be injected by a healthcare provider
    •Injections can be uncomfortable
    •Has serious risks if the toxin spreads to other parts of your body
    •Brand only, so might be expensive

  • Common Side Effects of Qbrexza vs. Botox

    Common Side Effects for
    •Dry mouth (24%)
    •Redness in the underarm (17%)
    •Burning and stinging in the underarm (14%)
    •Itchy skin (8%)
    •Widening of the pupils (7%)
    •Sore throat (6%)
    •Headache (5%)
    Common Side Effects for

    OAB

    •Urinary tract infection (UTI, 18%)
    •Painful urination (9%)
    •Difficulty passing urine (6%)

    Loss of bladder control

    •Urinary tract infection (UTI, 24-26% in adults, 7% in children)
    •Urine left in bladder (17% in adults)
    •Difficulty passing urine (15-17% in adults)
    •Bacteria in urine (9% in adults, 20% in children)
    •White blood cells in urine (7% in children)
    •Painful urination (5% in adults)

    Migraine prevention in adults

    •Neck pain (9%)
    •Headache (5%)

    ^*Not a comprehensive list of side effects, as they vary depending on the condition you have. Refer to the source below for more details.^

  • Warnings of Qbrexza vs. Botox

    Common Side Effects for
    •New or worsening urinary problems
    •Heat strokes and high body temperatures
    •Blurry vision
    Common Side Effects for
    •Spread of toxin effects
    •Serious allergic reaction
    •Higher risk of side effects
    •Difficulty swallowing or breathing
    •Reduced blinking and eye bleeding
    •Abnormal overreaction of your nervous system (autonomic dysreflexia)
    •Higher risk of urinary tract infections (UTI) and trouble urinating (urinary retention)

  • Prices with our coupons for Qbrexza vs. Botox

    Learn more about Qbrexza
    Learn more about Botox

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