provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content

Qbrexza

glycopyrronium
Used for Excessive Sweating
Used for Excessive Sweating

Qbrexza (glycopyrronium) is an anticholinergic medication used to treat excessive underarm sweating, also known as primary axillary hyperhidrosis, in people 9 years and older. It's available as a cloth that you use once a day to wipe both of your underarms. Common side effects include dry mouth, blurry vision, and constipation. The medication is only available under brand name Qbrexza, as a generic version isn't available.

Last reviewed on August 27, 2024
basics-icon

What is Qbrexza (glycopyrronium)?

What is Qbrexza (glycopyrronium) used for?

How Qbrexza (glycopyrronium) works

Qbrexza (glycopyrronium) is an anticholinergic medication. Anticholinergics work by blocking the activity of acetylcholine, a natural chemical in the body that activates sweat glands. So applying Qbrexza (glycopyrronium) to your underarms prevents acetylcholine from working in that area, which reduces sweating.

Are you looking for information on glycopyrrolate (Robinul) tablet or glycopyrrolate (Cuvposa) oral solution instead?

Drug Facts

Common BrandsQbrexza
Drug ClassAnticholinergic
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
coupon-save-icon

Get your GoodRx coupon

Avg retail price
$759.88(save 24.96%)
GoodRx discount
$570.18
See prices
basics-icon

What are the side effects of Qbrexza (glycopyrronium)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Dry mouth (24%)
  • Redness in the underarm (17%)
  • Burning and stinging in the underarm (14%)
  • Itchy skin (8%)
  • Widening of the pupils (7%)
  • Sore throat (6%)
  • Headache (5%)

Other Side Effects

  • Difficulty urinating
  • Blurry vision
  • Dry nose
  • Dry throat
  • Dry eye
  • Dry skin
  • Constipation

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Burning, itching, crusting, or peeling of treated skin
  • Fever that does not go away, decreased sweating
  • Trouble passing urine

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Qbrexza (glycopyrronium)

thumbs-up

Pros

Is a first-choice option to treat excessive underarm sweating

Applied to the underarms, directly targeting the sweat glands

Only need to apply once a day, every 24 hours

thumbs-down

Cons

Can cause problems urinating and blurred vision

Interacts with other anticholinergic medications

Risk of accidental exposure to others, especially children, leading to unwanted side effects

pharmacist-tips

Pharmacist tips for Qbrexza (glycopyrronium)

pharmacist
  • Qbrexza (glycopyrronium) is only FDA approved to treat excessive underarm sweating. Don’t use this medication on other parts of your body, unless directed by your prescriber.

    • Make sure to wipe Qbrexza (glycopyrronium) across clean dry skin. Don’t apply Qbrexza (glycopyrronium) if you have any cuts or tears on your underarms. Doing so can affect how well the drug works for you.

      • Wash your hands after using Qbrexza (glycopyrronium) to prevent your body from absorbing any extra medication. If you don't wash your hands and accidentally touch your eyes, you could experience blurry vision.

        • Throw away the used Qbrexza (glycopyrronium) wipe in the trash out of reach of others, especially children. There have been reports of children experiencing blurry vision and other eye problems after touching their eyes following contact with the used wipe.

          • Don’t drive or participate in activities requiring you to be alert if you have blurry vision while taking Qbrexza (glycopyrronium). You should stop taking this medication and contact a prescriber as soon as you notice these symptoms.

            • Dry mouth is a common side effect with Qbrexza (glycopyrronium). If this becomes bothersome, you can try remedies at home like chewing sugar-free gum, sipping cold water throughout the day, and using over-the-counter saliva substitutes to help.

              • Qbrexza (glycopyrronium) is an anticholinergic medication, and taking it with other anticholinergic medications can raise your risk for specific side effects like dry mouth, blurry vision, and constipation. When starting a new medication, check with a prescriber or pharmacist to make sure it doesn’t interact with Qbrexza (glycopyrronium).

                • Qbrexza (glycopyrronium) is a flammable medication, meaning it can easily catch on fire. Store it at room temperature in a cool, dry area, away from heat and flame.

                  faqs

                  Frequently asked questions about Qbrexza (glycopyrronium)

                  How long does Qbrexza (glycopyrronium) stay in your system?
                  Since Qbrexza (glycopyrronium) is applied to the skin of your underarm, only a small amount of the medication is absorbed into your body. The half-life, which measures how long it takes for your body to remove the medication from your system, is unknown for the wipes because so little enters the bloodstream. If you have questions about how long this medication stays in your system, speak with your prescriber.
                  How long do Qbrexza (glycopyrronium) side effects last?
                  Anticholinergic medications, like Qbrexza (glycopyrronium), often have similar side effects. These include dry mouth, blurry vision, constipation, problems urinating, and dry eye. In clinical studies, these side effects typically went away within 3 to 14 days, either on their own or with a dose adjustment. Let your prescriber know if any of these side effects become bothersome.
                  Can I use Qbrexza (glycopyrronium) in the morning?
                  Yes. Qbrexza (glycopyrronium) can be used at any time of the day. What's most important is that you use the medication at the same time each day, once every 24 hours. So choose the time of day that works best for you.
                  Can I use deodorant with Qbrexza (glycopyrronium)?
                  Yes. You can continue using an antiperspirant or deodorant under your arms along with Qbrexza (glycopyrronium).
                  Can you use Qbrexza (glycopyrronium) on your face, hands, or feet?
                  Currently, Qbrexza (glycopyrronium) is only FDA-approved for treating excessive sweating in the underarms. But, sometimes healthcare professionals will prescribe it off-label for excessive sweating in other areas of the body. Some studies have explored using Qbrexza (glycopyrronium) on such areas as the face and hands. If you have questions about using this medication elsewhere, talk to your prescriber.
                  Does Qbrexza (glycopyrronium) work right away?
                  Qbrexza (glycopyrronium) works fairly quickly because it's applied directly to your underarms, targeting the sweat glands in that area. In studies, some people noticed benefits within the first week, and most people can see results by the second week of treatment.
                  How long does Qbrexza (glycopyrronium) last?
                  Studies have shown that when used daily, Qbrexza (glycopyrronium) continues to reduce excessive underarm sweating for at least 48 weeks. But since the study only lasted 48 weeks, you might be able to continue treatment beyond that. Talk to your prescriber about how long you can safely use this medication.
                  GoodRxEducationalIcon

                  How to save using GoodRx

                  Compare Prices
                  1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
                  Select your free coupon
                  2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
                  Show coupon to your pharmacist
                  3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
                  Get free couponLearn more
                  warings-icon

                  What are the risks and warnings for Qbrexza (glycopyrronium)?

                  Qbrexza (glycopyrronium) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                  risk-warning

                  New or worsening urinary problems

                  • Risk factors: Enlarged Prostate | Blockage in the bladder

                    As with other anticholinergic medications, Qbrexza (glycopyrronium) can cause difficulty urinating. If you’ve had trouble emptying your bladder in the past, this medication can worsen your condition. Stop this medication right away if you have any difficulty passing urine, and contact your prescriber when you first notice these symptoms.

                    risk-warning

                    Heat strokes and high body temperatures

                    • Risk factors: Taking another anticholinergic medication | Exposed to hot or warm environments

                      People taking Qbrexza (glycopyrronium) are at a higher risk for heat strokes and high body temperatures when exposed to hot environments. Normally, sweating helps cool your body down in high temperatures, but Qbrexza (glycopyrronium) reduces sweating, raising the risk of overheating and heat stroke. If you notice you're sweating less, have red hot skin, fever, dizziness, or difficulty breathing, stop using the medication and contact your prescriber right away.

                      risk-warning

                      Blurry vision

                      • Risk factors: Taking another anticholinergic medication

                        You might temporarily have trouble seeing while taking Qbrexza (glycopyrronium), but it usually doesn't last long. If this happens, avoid driving, operating machinery, or doing anything that requires clear vision. Stop taking the medication until your vision improves, and contact your prescriber as soon as you notice blurry vision.

                        dosage

                        Qbrexza (glycopyrronium) dosage forms

                        The average cost for 1 box of 2.8g of 2.4% of Qbrexza (glycopyrronium) is $570.18 with a free GoodRx coupon. This is 24.96% off the average retail price of $759.88.
                        box
                        Box
                        DosageQuantityPrice as low asPrice per unit
                        2.8g of 2.4%1 box$570.18$570.18

                        Typical dosing for Qbrexza (glycopyrronium)

                        Wipe one cloth across one entire underarm once. Then, use the same cloth to wipe the other underarm once. Repeat these steps once a day, every 24 hours.

                        drug-cost

                        How much does Qbrexza (glycopyrronium) cost?

                        To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                        contraindications-icon

                        Qbrexza (glycopyrronium) contraindications

                        Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Qbrexza (glycopyrronium) will not be safe for you to take.
                        alternatives

                        What are alternatives to Qbrexza (glycopyrronium)?

                        There are a number of medications that your doctor can prescribe in place of Qbrexza (glycopyrronium). Compare a few possible alternatives below.
                        Qbrexza (glycopyrronium)
                        Used for:
                        $570.18 Lowest GoodRx priceView Prices
                        Used for:
                        • Overactive bladder (OAB) in adults

                        • Loss of bladder control due to nerve problems in people 5 years and older

                        • Headache prevention in adults with long-term migraine (headaches lasting 4 hours or longer for 15 or more days per month)

                        • Muscle spasms in people 2 years and older

                        • Neck spasms in adults

                        • Excessive armpit sweating in adults

                        • Eyelid twitching in people 12 years and older

                        • Crossed eyes in people 12 years and older

                        $1277.83 Lowest GoodRx priceView Prices
                        Used for:
                        $14.75 Lowest GoodRx priceView Prices

                        Get savings updates for Qbrexza (glycopyrronium)

                        Receive price alerts, news, and other messages from GoodRx about Qbrexza (glycopyrronium) and other healthcare topics and relevant savings offers.

                        By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

                        References

                        Best studies we found
                        View All References (6)

                        International Hyperhidrosis Society. (n.d.). Primary focal axillary hyperhidrosis.

                        Journey Medical Corporation. (2023). Qbrexza- glycopyrronium cloth [package insert]. DailyMed.

                        Ludmann, P. (2024). Hyperhidrosis: Diagnosis and treatment. American Academy of Dermatology Association.

                        Pariser, D., et al. (2022). Open-label cohort study to evaluate efficacy and safety of application of glycopyrronium cloth, 2.4% for palmar hyperhidrosis. Journal of Drugs in Dermatology.

                        Pariser, D. M., et al. (2019). Topical glycopyrronium tosylate for the treatment of primary axillary hyperhidrosis: Patient-reported outcomes from the ATMOS-1 and ATMOS-2 phase III randomized controlled trials. American Journal of Clinical Dermatology.

                        Pariser, D. M., et al. (2021). Limited systemic exposure with topical glycopyrronium tosylate in primary axillary hyperhidrosis. Clinical Pharmacokinetics.

                        GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
                        Was this page helpful?

                        Browse medications

                        View All

                        Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.