provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Glycopyrrolate Coupon - Glycopyrrolate 473ml of 1mg/5ml bottle of oral solution

glycopyrrolate

Generic Cuvposa
Used for Salivation
Used for Salivation

Cuvposa (glycopyrrolate) is an anticholinergic used to treat excessive drooling in children with certain conditions affecting the brain, such as cerebral palsy. The dosage that each child needs can vary. It comes as an oral solution and is available both as a brand-name and generic medications. Side effects include dry mouth, constipation, and sweating less.

Last reviewed on July 10, 2024
basics-icon

What is Cuvposa (glycopyrrolate)?

What is Cuvposa (glycopyrrolate) used for?

  • Excessive drooling in children ages 3 to 16 with certain conditions affecting the brain

How Cuvposa (glycopyrrolate) works

Cuvposa (glycopyrrolate) is an anticholinergic. It blocks a chemical called acetylcholine on salivary glands, where saliva is made and released into the mouth. While saliva can help with swallowing and chewing, too much can cause drooling. This is often seen in conditions that affect the brain, such as cerebral palsy.

Cuvposa (glycopyrrolate) helps manage this by lowering the amount of saliva that's made.

Are you looking for information on glycopyrrolate (Robinul) tablet instead?

Drug Facts

Common BrandsCuvposa
Drug ClassAnticholinergic
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
coupon-save-icon

Get your GoodRx coupon

Avg retail price
$490.770
GoodRx discount
$490.77
See prices
basics-icon

What are the side effects of Cuvposa (glycopyrrolate)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Dry mouth (40%)
  • Vomiting (40%)
  • Constipation (35%)
  • Flushing (30%)
  • Nasal congestion (30%)
  • Headache (15%)
  • Sinus inflammation (15%)
  • Upper respiratory infection (15%)
  • Difficulty urinating (15%)

Other Side Effects

  • Stomach bloating
  • Stomach pain or discomfort
  • Chapped lips
  • Gas
  • Feeling irritated or agitated
  • Pneumonia
  • Urinary tract infection
  • Faster heart rate
  • Dehydration
  • Changes in taste
  • Uncontrolled eye movement
  • Restlessness
  • Aggressive behavior
  • Crying
  • Moaning
  • Mood changes
  • Dry nose
  • Dry skin
  • Itching
  • Rash

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Intestinal blockage: diarrhea, stomach pain, bloating, nausea, vomiting
  • Serious allergic reaction: itchy red rash (hives), shortness of breath, chest tightness, swelling of lips, tongue, face, or eyes

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Bowel blockage—stomach cramping, unable to have a bowel movement or pass gas, loss of appetite, vomiting
  • Diarrhea
  • Fever that does not go away, decreased sweating
  • Trouble passing urine

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Cuvposa (glycopyrrolate)

thumbs-up

Pros

Works well to treat severe drooling

Convenient to prepare the dose

Available in a liquid cherry flavor, making it easier for children to take

thumbs-down

Cons

Has many unpleasant anticholinergic side effects

Needs to be taken multiple times per day

Must be taken on an empty stomach

pharmacist-tips

Pharmacist tips for Cuvposa (glycopyrrolate)

pharmacist
  • Take Cuvposa (glycopyrrolate) on an empty stomach, which is at least 1 hour before or 2 hours after meals. Food can lower the amount of medication that gets absorbed into the body, so it might not work as well.

    • Use a dosing cup to measure out your child's dose of Cuvposa (glycopyrrolate). Then, using an oral syringe, draw up the dose from the cup and place it in your child's mouth. Avoid using a kitchen teaspoon, as it doesn't provide an accurate measurement.

      • Constipation, a common side effect of Cuvposa (glycopyrrolate), typically happens within the first 4 to 5 days of starting the medication or after a dose is raised. If your child is constipated, stop the medication and let their pediatrician know because this could be a sign of a more serious stomach problem.

        • Cuvposa (glycopyrrolate) can sometimes cause difficulty urinating. Dry diapers or underwear, crying, and irritability can be signs that your child is having difficulty urinating. Stop the medication and call their pediatrician if your child isn't urinating.

          • Try to keep your child away from hot environments when they are taking Cuvposa (glycopyrrolate). This medication can reduce sweating which can lead to overheating.

            • Store Cuvposa (glycopyrrolate) at room temperature and out of reach from children to avoid potential overdose.

              faqs

              Frequently asked questions about Cuvposa (glycopyrrolate)

              Does Cuvposa (glycopyrrolate) cause weight gain?
              Probably not. In clinical studies, weight gain was not listed as a side effect for those taking Cuvposa (glycopyrrolate). If your child is gaining weight after taking this medication, talk to their pediatrician.
              How long does Cuvposa (glycopyrrolate) stay in your system?
              It takes 12 to 15 hours for most of Cuvposa (glycopyrrolate) to leave your body after a single dose. This time frame is estimated based on the half-life of Cuvposa (glycopyrrolate).
              How long does Cuvposa (glycopyrrolate) last?
              Although it does take about 3 hours for the body to fully absorb Cuvposa (glycopyrrolate), how long it lasts depends on many things. But what's important is that for the medication to work well, your child will need to take it 3 times a day. Talk to your child's pediatrician if you have questions about this medication.
              How long does it take for Cuvposa (glycopyrrolate) to work?
              In clinical studies, Cuvposa (glycopyrrolate) started working to reduce drooling in children as early as 4 weeks. Keep in mind that everyone is different. In some instances, it might take at least 8 weeks for it to work fully. Discuss with your child's pediatrician about how long this medication is expected to work for your child.
              Does Cuvposa (glycopyrrolate) cause hair loss?
              Probably not. Hair loss wasn't reported as a side effect in clinical studies of people taking Cuvposa (glycopyrrolate). If your child is experiencing hair loss after taking this medication, let their pediatrician know.
              Is Cuvposa (glycopyrrolate) an anticholinergic?
              Yes. Cuvposa (glycopyrrolate) belongs to a class of medications called anticholinergics.
              Can younger children take Cuvposa (glycopyrrolate)?
              Cuvposa (glycopyrrolate) has only been studied in children ages 3 to 16. Because there aren't any studies in children under age 3, discuss the risks and benefits of using Cuvposa (glycopyrrolate) with your child's pediatrician.
              What's the difference between Cuvposa (glycopyrrolate) and Robinul (glycopyrrolate)?
              Although they contain the same active ingredient (glycopyrrolate) they are approved for different uses. Cuvposa (glycopyrrolate) is an oral solution used to treat excessive drooling in children ages 3 to 16 with certain conditions that affect the brain. Robinul (glycopyrrolate) is a tablet used as an add-on treatment for stomach ulcers and can't be used in children under the age of 12. Cuvposa (glycopyrrolate) and glycopyrrolate (Robinul) can't be substituted for each other because they are available in different dosage forms and contain different amounts of glycopyrrolate.
              GoodRxEducationalIcon

              How to save using GoodRx

              Compare Prices
              1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
              Select your free coupon
              2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
              Show coupon to your pharmacist
              3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
              Get free couponLearn more
              warings-icon

              What are the risks and warnings for Cuvposa (glycopyrrolate)?

              Cuvposa (glycopyrrolate) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Constipation

              • Risk factors: Taking other medications that cause constipation

                Constipation is a common side effect of Cuvposa (glycopyrrolate), especially within the first 4 to 5 days of starting the medication and after a dose is raised. If your child complains of constipation, stomach pain, swelling, nausea, and vomiting, stop Cuvposa (glycopyrrolate) and tell their pediatrician because this could be a sign of intestinal pseudo-obstruction (a rare condition that prevents your intestinal muscles from moving).

                risk-warning

                Blockage in the intestine

                • Risk factors: History of surgical procedures of the intestines, such as ileostomy or colostomy

                  Cuvposa (glycopyrrolate) can cause blockage in the intestine. Diarrhea can be an early sign of this blockage, especially if your child has a history of surgical procedures in the intestines, like an ileostomy or colostomy. If your child has diarrhea, stop Cuvposa (glycopyrrolate) and let their pediatrician know.

                  risk-warning

                  Heat stroke or fever

                  • Risk factors: Hot weather | Strenuous activity or exercise | Taking other anticholinergic medications

                    Cuvposa (glycopyrrolate) can cause your child to sweat less, which can lead to fever or heat strokes in hot weather. To avoid overheating, have your child cool down and rest in the shade, drink cold water, and take breaks while running around or playing. Call their pediatrician right away if your child becomes sick, less alert, passes out, or has any other symptoms of heatstroke, such as hot and red skin, fast heartbeat, difficulty breathing, or fever.

                    risk-warning

                    Sleepiness or blurred vision

                    • Risk factors: Taking other medications that cause sleepiness or blurred vision

                      Cuvposa (glycopyrrolate) can cause sleepiness or blurred vision. Don’t let your child do any activities that require concentration until you know how Cuvposa (glycopyrrolate) affects your child.

                      risk-warning

                      Worsening of other health conditions

                      Some health conditions can worsen if your child takes Cuvposa (glycopyrrolate). For example, if your child has heart problems, be careful when giving this medication because it can raise their heart rate.

                      If your child has an inflamed colon (ulcerative colitis), higher doses of Cuvposa (glycopyrrolate) can slow their stomach and intestinal muscles, which can lead to life-threatening conditions of the intestine. Talk to their pediatrician if you’re concerned about certain worsening conditions for your child.

                      dosage

                      Cuvposa (glycopyrrolate) dosage forms

                      The average cost for 1 bottle of 473ml of 1mg/5ml of Cuvposa (glycopyrrolate) is $493.01 with a free GoodRx coupon. This is 19% off the average retail price of $608.64.
                      bottle of oral solution
                      Bottle of oral solution
                      DosageQuantityPrice as low asPrice per unit
                      473ml of 1mg/5ml1 bottle$493.01$493.01

                      Typical dosing for Cuvposa (glycopyrrolate)

                      The dosing is based on your child's weight.

                      The typical starting dose is 0.02 mg/kg by mouth three times daily. Your child's pediatrician will slowly raise the dose every 5 to 7 days, depending on how well the medication is working and if your child experiences side effects.

                      The maximum dose is 0.1 mg/kg three times daily, with no doses greater than 1.5 to 3 mg per dose based on weight.

                      drug-cost

                      How much does Cuvposa (glycopyrrolate) cost?

                      To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                      contraindications-icon

                      Cuvposa (glycopyrrolate) contraindications

                      Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Cuvposa (glycopyrrolate) will not be safe for you to take.
                      alternatives

                      What are alternatives to Cuvposa (glycopyrrolate)?

                      There are a number of medications that your doctor can prescribe in place of Cuvposa (glycopyrrolate). Compare a few possible alternatives below.
                      Cuvposa (glycopyrrolate)
                      Used for:
                      • Excessive drooling in children ages 3 to 16 with certain conditions affecting the brain

                      $490.77 Lowest GoodRx priceView Prices
                      Used for:
                      • Long-term excessive drooling (sialorrhea) in people 2 years and older

                      • Arm spasms in people 2 years and older

                      • Uncontrollable neck spasms (cervical dystonia) in adults

                      • Uncontrollable eye twitching (blepharospasm) in adults

                      • Frown lines in adults

                      images

                      Cuvposa (glycopyrrolate) images

                      colorless - Glycopyrrolate 1mg / 5mL Oral Solution
                      This medicine is Colorless Bottle Of Oral Solution.colorless - Glycopyrrolate 1mg / 5mL Oral Solution
                      colorless - Glycopyrrolate 1mg / 5mL Oral Solution
                      This medicine is Colorless Bottle Of Oral Solution.colorless - Glycopyrrolate 1mg / 5mL Oral Solution
                      colorless - Glycopyrrolate 1mg / 5mL Oral Solution
                      This medicine is Colorless Bottle Of Oral Solution.colorless - Glycopyrrolate 1mg / 5mL Oral Solution
                      This medicine is Colorless Bottle Of Oral Solution.

                      Get savings updates for Cuvposa (glycopyrrolate)

                      Receive price alerts, news, and other messages from GoodRx about Cuvposa (glycopyrrolate) and other healthcare topics and relevant savings offers.

                      By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

                      References

                      Best studies we found

                      Canadian Agency for Drugs and Technologies in Health. (2020). Discussion. Clinical Review Report: Glycopyrrolate Oral Solution (Cuvposa): (Medexus Pharmaceuticals, Inc.): Indication: Chronic severe drooling, neurologic (pediatric).

                      Desai, J., et al. (2020). Toxic megacolon: Background, pathophysiology, management challenges and solutions. Clinical and Experimental Gastroenterology.

                      Inenaga, K., et al. (2010). Oral dryness and thirst: – The central effect of acetylcholine on drinking behavior–. Journal of Oral Biosciences.

                      View All References (6)

                      Jackson, P. G., et al. (2011). Evaluation and management of intestinal obstruction. American Family Physician.

                      MedlinePlus. (2022). Ileostomy.

                      MedlinePlus. (2022). Intestinal obstruction and ileus.

                      MedlinePlus. (2024). Colostomy.

                      National Institute of Diabetes and Digestive and Kidney Diseases. (2021). Intestinal Pseudo-obstruction.

                      Suven Pharmaceuticals Limited. (2024). Glycopyrrolate oral solution liquid [package insert]. DailyMed.

                      GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
                      Was this page helpful?

                      Browse medications

                      View All

                      Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.