How long does Daxxify take to work?

Daxxify might work as early as the [next day](https://www.daxxify.com/faqs) after your treatment. It typically works within 2 days.

Is Daxxify FDA approved?

Yes, the FDA first approved Daxxify for temporarily improving the appearance of frown lines in 2022. Later in [2023](https://investors.revance.com/investors/Press-Releases/news-details/2023/U.S.-FDA-Approves-First-Therapeutic-Indication-for-Revances-DAXXIFY-DaxibotulinumtoxinA-lanm-for-Injection-for-the-Treatment-of-Cervical-Dystonia/default.aspx), the medication was approved for treating cervical dystonia in adults.

Daxxify

daxibotulinumtoxinA-lanm

Used for Facial Wrinkles

Daxxify (daxibotulinumtoxinA or daxibotulinumtoxinA-lanm) is an FDA-approved medication for adults to temporarily improve the appearance of frown lines (wrinkles between your eyebrows and in your forehead). It's also used to treat cervical dystonia (muscle spasms in the neck). This medication is injected into the muscles by a trained healthcare provider. Common side effects include headache and pain at the injection site. Daxxify seems to last longer than other botulinum toxin injections (e.g., Botox).

Reviewed by:

Kristianne Hannemann, PharmD

Cydnee Ng, PharmD

Last reviewed on November 6, 2023

What is Daxxify?

What is Daxxify used for?

Temporary improvement in the appearance of moderate-to-severe frown lines (glabellar lines) in adults
Neck spasms (cervical dystonia) in adults

How Daxxify works

Daxxify is a neuromuscular blocker. It's a toxin made from bacteria (Clostridium botulinum) that temporarily lowers muscle activity by blocking nerve signals that cause muscles to contract (tighten). This helps relax the muscles that cause frown lines and neck spasms.

Are you looking for information on Botox Cosmetic (onabotulinumtoxinA) or Jeuveau (prabotulinumtoxinA) instead?

Drug facts

Common BrandsDaxxify

Drug ClassNeuromuscular blocker

Controlled Substance ClassificationNot a controlled medication

Generic StatusNo lower-cost generic available

AvailabilityPrescription only

More on Daxxify essentials

A patient gets a filler injected into his forehead.
FG Trade/E+ via Getty Images

Daxxify vs. Botox Cosmetic for Wrinkles

Written by Sarah Lobello Pearson, PharmD

Side effects of Daxxify

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Frown lines

Headache (6%)
Injection site reactions (e.g., pain, redness, swelling; 6%)
Drooping eyelids (2%)
Trouble moving parts of the face (1%)

Cervical dystonia

Headache (7-9%)
Injection site reactions (e.g., pain, redness; up to 8%)
Upper respiratory tract infection (up to 5%)
Muscle weakness (2-5%)
Muscle and bone pain (4%)
Trouble swallowing (2-4%)
Spine pain (2-3%)

Less Common Side Effects

Joint pain
Urinary tract infection

Daxxify serious side effects

Contact your healthcare provider immediately if you experience any of the following.

Trouble breathing or swallowing
Serious allergic reaction: swelling in the lips, tongue, or face; shortness of breath; hives

Source: DailyMed

The following Daxxify side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Dryness or irritation of the eyes, eye pain, change in vision, sensitivity to light
Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
Spread of botulinum toxin effects—unusual weakness or fatigue, blurry or double vision, trouble swallowing, hoarseness or trouble speaking, trouble breathing, loss of bladder control

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

Eyelid drooping
Headache
Muscle weakness
Pain, redness, or irritation at injection site

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Avg retail price

$504.99(Save 15.97%)

GoodRx discount

$424.32

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Pros and cons of Daxxify

Pros

Works well to improve the look of frown lines
Can last for up to 6 months or longer for moderate-to-severe frown lines
Injected directly into the muscles causing your condition to help them relax
Given by a trained healthcare provider

Cons

Injections can be painful
Can cause headache and muscle weakness
Requires repeat injections since effects are temporary
Brand only

Pharmacist tips for Daxxify

Before you get your Daxxify injections, your provider might ice the area or apply some numbing cream. This will help lessen discomfort from the injections.
The area(s) where your provider injected Daxxify into might be red, tender, or swollen. This should get better within a few hours or days. Contact your provider if you have any concerns.
When using for frown lines: You might have dry eyes after your Daxxify treatment session. Consider using lubricating eye drops to ease the discomfort.
Avoid driving a car or performing activities that require good vision and muscle strength if you notice problems with your muscles or vision (such as blurry vision or droopy eyelids) after you get your Daxxify injections.
Rarely, Daxxify can cause vision problems. Talk with your provider right away if you notice eye pain or changes in your vision, such double vision or light sensitivity.
Though rare, it's possible for Daxxify to spread beyond the original injection site. This can lead to serious side effects, such as muscle weakness, double vision, trouble swallowing, and breathing problems. These side effects can happen hours to weeks after the injection, so look out for these side effects after you go home. Call your provider right away if you have these symptoms.
If you need a repeat treatment of Daxxify, you'll need to wait at least 3 months in between each session. Getting Daxxify more often than recommended can raise your risk of serious side effects such as breathing problems or muscle weakness. Talk with your provider if you have questions about how often you can get treated.

Common questions about Daxxify

Everyone who uses Daxxify can have different results. In clinical studies, at least 50% of people with moderate-to-severe frown lines who were treated with Daxxify saw improvements in their appearance 6 months after their injections. Some people noticed effects lasting up to 9 months. And for those with cervical dystonia, the effects of Daxxify also lasted for at least about 6 months during clinical studies.

Daxxify might work as early as the next day after your treatment. It typically works within 2 days.

You'll need to visit a provider's office for treatment since Daxxify must be injected by a trained healthcare provider. It's important that you get the right dose at the right time and that the medication is safely injected because it can cause serious side effects if too much is used or if it's not injected properly. Visit the Practice Locator website to find a healthcare provider who can administer Daxxify to you.

The amount of units of Daxxify you'll need depends on your condition. For frown lines, your provider will give you five injections containing 8 units of medication each. For cervical dystonia, you'll get between 125 and 250 units, depending on how much your provider thinks you need. Your provider can adjust the dose based on how you respond to the medication.

Both medications work similarly, but what they can be used for differs. Daxxify can be used for frown lines and cervical dystonia (neck spasms), whereas Botox (onabotulinumtoxinA) is used for treating many different types of movement or muscle problems and preventing headaches. There's another brand called Botox Cosmetic (onabotulinumtoxinA) that's specifically approved to treat frown lines, forehead lines, and crow's feet lines around the eyes. Studies have shown that Daxxify might keep frown lines relaxed for a longer time in between injections than Botox Cosmetic. Talk to your provider for more information about the differences between Daxxify and Botox.

There isn't enough information available to know whether Daxxify is safe to use during pregnancy. In animal studies, high doses of Daxxify caused harm to unborn babies and pregnant mothers. Discuss the risks and benefits of this medication with your provider if you're pregnant or thinking of becoming pregnant.

Yes, the FDA first approved Daxxify for temporarily improving the appearance of frown lines in 2022. Later in 2023, the medication was approved for treating cervical dystonia in adults.

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Risks and warnings for Daxxify

Daxxify can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Spread of toxin effects

Risk factors: History of muscle, eye, or lung conditions

Black Box Warning Although no serious reports with Daxxify have been made, the medication has the potential to spread to other body areas outside of the injection site and cause toxic effects. These effects can potentially happen hours to weeks after the injection. Serious side effects can include unexplained muscle weakness, drooping eyelids, blurred or double vision, trouble breathing or swallowing, slurred speech or trouble speaking, or the need to urinate more frequently. Seek medical help right away if you notice any of these side effects.

Allergic reaction

Allergic reactions, including anaphylaxis, are possible with Daxxify. Get medical help right away if you have shortness of breath, hives, fever, or swelling after you get treated with Daxxify.

Worsening of certain conditions

Risk factors: History of certain muscle-nerve conditions | History of heart problems | Inflammation (swelling) at the injection site

In people with certain medical conditions, Daxxify can make symptoms worse and cause serious side effects.

Some people who used botulinum toxin products like Daxxify have reported heart problems including heart attack and arrhythmias (racing heart). In addition, people with certain muscle-nerve conditions (e.g., myasthenia gravis) might have a higher risk of serious side effects from the medication, including muscle weakness anywhere in the body; blurry vision; drooping eyelids; and trouble speaking, eating, drinking, or breathing. Seek medical help right away if you have any of these side effects.

Make sure to discuss your full medical history with your provider before you use Daxxify. You should also let your provider know if you have any redness or swelling at the areas where you'll be getting the injections or if you currently have drooping eyelids or muscle weakness. Daxxify might worsen these symptoms.

Difficulty swallowing or breathing

Risk factors: History of swallowing or breathing problems | Current muscle-nerve conditions

Daxxify can cause problems with swallowing or breathing by weakening the muscles involved in these functions. Sometimes, these problems can be life-threatening. Problems with swallowing or breathing can happen hours to weeks after you get Daxxify and can last for many months. Your risk is higher if you have certain conditions affecting your muscles or nerves. Tell your provider if you have a history of swallowing or breathing problems before you start treatment. And seek medical help right away if you notice any problems with swallowing or breathing after you get your injections.

Reduced blinking, dry eye, and vision changes (when used for frown lines)

Daxxify can cause dry eyes when the medication is used for temporarily improving frown lines. In addition, people who've used botulinum toxin products like Daxxify have reported making less tears and blinking less often. Talk to your provider if you have eye irritation, sensitivity to light, or visual changes that don't go away.

Daxxify dosage

The average cost for 1 vial of 100 units of Daxxify is $424.32 with a free GoodRx coupon. This is 15.97% off the average retail price of $504.99.

Vial

Dosage	Quantity	Price as low as	Price per unit
100 units	1 vial	$424.32	$424.32

Typical dosage for Daxxify

Daxxify is only available as an intramuscular (IM) injection that's administered by a healthcare provider.

Frown lines: The typical recommended dose per treatment session is 40 units (divided into 5 smaller doses) injected into the affected muscles.
Neck spasms: The typical dose ranges from 125 units to 250 units, given as divided doses and injected into the affected muscles.

How much does Daxxify cost?

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Daxxify (brand)

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Daxxify contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Daxxify will not be safe for you to take.

Infection at injection site

What are alternatives to Daxxify?

There are a number of medications that your doctor can prescribe in place of Daxxify. Compare a few possible alternatives below.

Daxxify

Used for:

Temporary improvement in the appearance of moderate-to-severe frown lines (glabellar lines) in adults
Neck spasms (cervical dystonia) in adults

$424.32Lowest GoodRx priceView prices

Botox Cosmetic (onabotulinumtoxinA)

Used for:

Temporarily improves the appearance of moderate to severe facial lines, including:

Frown lines
Crow's feet
Forehead lines
Neck lines

$366.55Lowest GoodRx priceView prices

Jeuveau (prabotulinumtoxinA)

Used for:

Temporary improvement in moderate-to-severe frown lines (glabellar lines) in adults

View prices

News about Daxxify

16 Botox Alternatives: How This Anti-Wrinkle Treatment Stacks Up to Jeuveau, Dysport, and More

Botox may be the first name that comes to mind for treating lines and wrinkles, but it’s not your only option. Learn about some Botox alternatives in this guide.

Daxxify vs. Botox Cosmetic for Wrinkles

Daxxify is an injectable that targets wrinkles similar to botox. Learn how Daxxify works and how effective it is compared to Botox as an anti-wrinkle treatment.

References

Best studies we found

Bertucci, V., et al. (2019). DaxibotulinumtoxinA for Injection has a prolonged duration of response in the treatment of glabellar lines: Pooled data from two multicenter, randomized, double-blind, placebo-controlled, phase 3 studies (SAKURA 1 and SAKURA 2). Journal of the American Academy of Dermatology.

Carruthers, J. D., et al. (2020). DaxibotulinumtoxinA for injection for the treatment of glabellar lines: Results from each of two multicenter, randomized, double-blind, placebo-controlled, phase 3 studies (SAKURA 1 and SAKURA 2). Plastic and Reconstructive Surgery.

Jankovic, J., et al. (2018). Injectable DaxibotulinumtoxinA in cervical dystonia: A phase 2 dose-escalation multicenter study. Movement Disorders Clinical Practice.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

Compare other Facial Wrinkles drugs

Botox-cosmetic vs Daxxify Daxxify vs Botox Aimovig vs Botox Botox-cosmetic vs Jeuveau Dysport vs Botox Jeuveau vs Botox Kybella vs Botox-cosmetic Qbrexza vs Botox Renova vs Botox-cosmetic Tretinoin vs Botox Vyepti vs Botox Xeomin vs Botox Xeomin vs Botox-cosmetic

Daxxify