Jeuveau
Jeuveau (prabotulinumtoxinA or prabotulinumtoxinA-xvfs) is a neuromuscular blocker made of botulism toxin. It's injected into certain muscles on the forehead to improve the looks of frown lines in adults. If you need more than one treatment, your HCP can inject Jeuveau (prabotulinumtoxinA) at most once every 3 months. Jeuveau (prabotulinumtoxinA) should only be given by a licensed healthcare professional (HCP) in a healthcare setting. Some common side effects of this medication include headache and pain at the injection site.
What is Jeuveau (prabotulinumtoxinA)?
What is Jeuveau (prabotulinumtoxinA) used for?
- Temporary improvement in moderate-to-severe frown lines (glabellar lines) in adults
How Jeuveau (prabotulinumtoxinA) works
Jeuveau (prabotulinumtoxinA) is a neuromuscular blocker. It's made of botulism toxin made from bacteria (Clostridium botulinum). When injected into muscles in the forehead, it temporarily relaxes the muscles by stopping a chemical called acetylcholine from being released. This helps your frown lines appear smoother.
Drug facts
More on Jeuveau (prabotulinumtoxinA) essentials
Side effects of Jeuveau (prabotulinumtoxinA)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Headache (12%)
- Upper respiratory tract infection (e.g., common cold; 3%)
- Drooping eyelid (2%)
Less Common Side Effects
- Injection-site reactions (e.g., pain, swelling, redness)
Jeuveau (prabotulinumtoxinA) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Trouble breathing or swallowing
Pros and cons of Jeuveau (prabotulinumtoxinA)
Pros
- Works well to improve the appearance of moderate-to-severe frown lines
- Injected directly at the affected area on the forehead
- Effects can last many months after each treatment
Cons
- Results aren't permanent, might need re-treatment
- Can experience headaches as side effects
- Unknown if safe to use during pregnancy or breastfeeding
Pharmacist tips for Jeuveau (prabotulinumtoxinA)
- Jeuveau (prabotulinumtoxinA) is given by a trained healthcare professional in a medical office. You shouldn't receive this medication more than once every 3 months.
- You might experience redness, swelling, or pain at the injection sites after getting Jeuveau (prabotulinumtoxinA). This is normal and should go away within a few days. If these reactions don't get better or seem to be getting worse, contact your prescriber.
- A possible side effect of Jeuveau (prabotulinumtoxinA) is droopy eyelids. If this happens, avoid driving or performing activities that require you to see well until your eyelids return back to normal.
- Jeuveau (prabotulinumtoxinA) can cause dry eyes. If your eyes are dry, consider using lubricating eye drops to ease the discomfort.
- Though rare, Jeuveau (prabotulinumtoxinA) can cause vision problems. Talk with your prescriber right away if you notice eye pain or changes in your vision, such double vision or light sensitivity.
- Let your provider know if you develop any unusual symptoms after your Jeuveau (prabotulinumtoxinA) injection. These can include trouble swallowing or speaking. If you have trouble breathing, get medical attention right away.
Common questions about Jeuveau (prabotulinumtoxinA)
The amount of time that the effects of Jeuveau (prabotulinumtoxinA) last varies from person to person. For most people, the effects of Jeuveau (prabotulinumtoxinA) last for a few months. In one study, around 15-25% of people had no lines or mild lines at about 5 months after getting Jeuveau (prabotulinumtoxinA). In general, you shouldn't get Jeuveau (prabotulinumtoxinA) more than once every 3 months.
Jeuveau (prabotulinumtoxinA) is injected into certain forehead muscles by a trained healthcare professional. Typically, a small dose of Jeuveau (prabotulinumtoxinA) (about 5 units) is injected into five different sites on the forehead.
No, Jeuveau (prabotulinumtoxinA) isn't a filler. Dermal fillers are injections that contain substances that help temporarily smooth wrinkles and add fullness to certain areas of the body. Jeuveau (prabotulinumtoxinA) works differently because it blocks nerve signals in your muscles to smooth wrinkles. Talk with your dermatologist about which option would work best for your skincare goals.
In general, a total dose of 20 units of Jeuveau (prabotulinumtoxinA) is split up and injected into muscles at five different areas on the forehead. Because of serious risks, Jeuveau (prabotulinumtoxinA) should only be injected by a trained healthcare professional (HCP). Your HCP might change your dose until they find the dose that works best for you.
It's possible for some people to experience a headache after using Jeuveau (prabotulinumtoxinA). In clinical studies, 12% of people who took Jeuveau (prabotulinumtoxinA) reported headache as a side effect. However, people who got a placebo injection (no medication) reported headache as a side effect too. Contact your HCP if your headache is severe or isn't going away after taking pain-relieving medication.
Both Jeuveau (prabotulinumtoxinA) and Botox (onabotulinumtoxinA) are toxins made from bacteria (Clostridium botulinum). One main difference is what they're FDA-approved to treat. Both Jeuveau and Botox Cosmetic can ease frown lines. But Botox Cosmetic can also improve the looks of forehead lines and crow's feet. In addition, there's a non-cosmetic version of Botox that's approved to treat many medical conditions, including muscle spasms and overactive bladder. Talk with your HCP if you've questions about Jeuveau and Botox.
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Risks and warnings for Jeuveau (prabotulinumtoxinA)
Jeuveau (prabotulinumtoxinA) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Spread of toxin effects
Botulinum toxin medications, such as Jeuveau (prabotulinumtoxinA), can spread to other body areas outside of the injection site and cause toxic effects, occurring hours to weeks after receiving the medication. This can cause serious side effects, such as unexplained muscle weakness, drooping eyelids, blurred or double vision, breathing or swallowing difficulty, slurred speech or trouble speaking, or the need to urinate more frequently. If you notice any of these side effects, seek medical help right away.
Severe allergic reactions
In some rare cases, medications like Jeuveau (prabotulinumtoxinA) can cause life-threatening allergic reactions. If you experience swelling in your face or throat, hives, or trouble breathing, get medical attention immediately. Your HCP might ask you to stop using Jeuveau (prabotulinumtoxinA) and other similar medications if you have a serious allergic reaction.
Difficulty swallowing or breathing
- Risk factors: History of swallowing or breathing problems | Myasthenia gravis | Lambert-Eaton syndrome | Current muscle-nerve conditions
Medications similar to Jeuveau (prabotulinumtoxinA) have caused life-threatening problems with swallowing or breathing by weakening muscles involved in these activities. This can occur hours to weeks after receiving the medication, and the effects can last for many months. Your risk is higher if you have certain conditions affecting your muscles or nerves, or if you're receiving Jeuveau (prabotulinumtoxinA) in areas of the body other than what it was approved for. If you have a history of swallowing or breathing problems, let your HCP know before starting Jeuveau (prabotulinumtoxinA) treatment. Seek medical help right away if you notice any trouble swallowing or breathing.
Worsening of certain conditions
- Risk factors: History of certain muscle-nerve conditions | History of heart problems | Inflammation at injection site
In people with certain medical conditions, Jeuveau (prabotulinumtoxinA) can make symptoms worse and cause serious side effects. Heart problems, including arrhythmia (irregular heartbeat) and heart attack, have been reported after people received botulinum toxin medications like Jeuveau (prabotulinumtoxinA). People with certain muscle-nerve conditions may have a higher risk of serious side effects from Jeuveau (prabotulinumtoxinA), including muscle weakness in the body, double vision, drooping eyelids, and trouble speaking, eating, drinking, or breathing. If you experience any of these side effects, seek medical help immediately.
Make sure to discuss your full medical history with your HCP before using Jeuveau (prabotulinumtoxinA). You should also let your HCP know if you have any redness or swelling at the areas on your body where you'll be getting the injections, or if you're currently experiencing drooping eyelids or muscle weakness.
Dry eyes
Some people experience dry eyes with the use of botulinum toxin medications like Jeuveau (prabotulinumtoxinA) for frown lines. If symptoms of dry eye (e.g., eye irritation, sensitivity to light, vision changes) don't go away, let your HCP know. You might need to see an eye specialist.
Jeuveau (prabotulinumtoxinA) dosage
Typical dosage for Jeuveau (prabotulinumtoxinA)
Jeuveau (prabotulinumtoxinA) is only available as an intramuscular (IM) injection that's administered by a healthcare professional (HCP). The dose of Jeuveau (prabotulinumtoxinA) is measured in units.
- Adults: Typically, your HCP will inject 4 units of Jeuveau (prabotulinumtoxinA) into each of the 5 sites on your forehead, for a maximum of 20 units total per treatment. You can receive a treatment no more often than once every 3 months.
Jeuveau (prabotulinumtoxinA) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Jeuveau (prabotulinumtoxinA) will not be safe for you to take.
- Infection at injection site
What are alternatives to Jeuveau (prabotulinumtoxinA)?
Temporarily improves the appearance of moderate to severe facial lines, including:
