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Jeuveau

prabotulinumtoxinA
Used for Facial Wrinkles
Used for Facial Wrinkles

Jeuveau (prabotulinumtoxinA or prabotulinumtoxinA-xvfs) is a neuromuscular blocker made of botulism toxin. It's injected into certain muscles on the forehead to improve the looks of frown lines in adults. If you need more than one treatment, your HCP can inject Jeuveau (prabotulinumtoxinA) at most once every 3 months. Jeuveau (prabotulinumtoxinA) should only be given by a licensed healthcare professional (HCP) in a healthcare setting. Some common side effects of this medication include headache and pain at the injection site.

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Allison Gourley, PharmD
Last reviewed on June 3, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageContraindicationsAlternativesLatest newsReferencesPricesMedicare
basics-icon

What is Jeuveau (prabotulinumtoxinA)?

What is Jeuveau (prabotulinumtoxinA) used for?

  • Temporary improvement in moderate-to-severe frown lines (glabellar lines) in adults

How Jeuveau (prabotulinumtoxinA) works

Jeuveau (prabotulinumtoxinA) is a neuromuscular blocker. It's made of botulism toxin made from bacteria (Clostridium botulinum). When injected into muscles in the forehead, it temporarily relaxes the muscles by stopping a chemical called acetylcholine from being released. This helps your frown lines appear smoother.

Are you looking for information on Botox Cosmetic (onabotulinumtoxinA), Xeomin (incobotulinumtoxinA), or Dysport (abobotulinumtoxinA) instead?

Drug Facts

Common BrandsJeuveau
Drug ClassNeuromuscular blocker
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Jeuveau (prabotulinumtoxinA) essentials

Health: Botox: woman at botox consultation 1154030721

Botox vs. Jeuveau: Uses, Side Effects, Costs, and More

Written by Connie Zheng, PharmD
basics-icon

What are the side effects of Jeuveau (prabotulinumtoxinA)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache (12%)
  • Upper respiratory tract infection (e.g., common cold; 3%)
  • Drooping eyelid (2%)

Other Side Effects

  • Injection-site reactions (e.g., pain, swelling, redness)

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Trouble breathing or swallowing

Source: DailyMed

pros-and-cons

Pros and cons of Jeuveau (prabotulinumtoxinA)

thumbs-up

Pros

Works well to improve the appearance of moderate-to-severe frown lines

Injected directly at the affected area on the forehead

Effects can last many months after each treatment

thumbs-down

Cons

Results aren't permanent, might need re-treatment

Can experience headaches as side effects

Unknown if safe to use during pregnancy or breastfeeding

pharmacist-tips

Pharmacist tips for Jeuveau (prabotulinumtoxinA)

pharmacist

  • Jeuveau (prabotulinumtoxinA) is given by a trained healthcare professional in a medical office. You shouldn't receive this medication more than once every 3 months.

    • You might experience redness, swelling, or pain at the injection sites after getting Jeuveau (prabotulinumtoxinA). This is normal and should go away within a few days. If these reactions don't get better or seem to be getting worse, contact your prescriber.

      • A possible side effect of Jeuveau (prabotulinumtoxinA) is droopy eyelids. If this happens, avoid driving or performing activities that require you to see well until your eyelids return back to normal.

        • Jeuveau (prabotulinumtoxinA) can cause dry eyes. If your eyes are dry, consider using lubricating eye drops to ease the discomfort.

          • Though rare, Jeuveau (prabotulinumtoxinA) can cause vision problems. Talk with your prescriber right away if you notice eye pain or changes in your vision, such double vision or light sensitivity.

            • Let your provider know if you develop any unusual symptoms after your Jeuveau (prabotulinumtoxinA) injection. These can include trouble swallowing or speaking. If you have trouble breathing, get medical attention right away.

              faqs

              Frequently asked questions about Jeuveau (prabotulinumtoxinA)

              How long does Jeuveau (prabotulinumtoxinA) take to work?
              Each person will respond differently to Jeuveau (prabotulinumtoxinA). In clinical studies, about 70% of people saw improvement in their frown lines 30 days after treatment. In another study, more than half of the participants saw results as early as 2 days after receiving the medication.
              How long does Jeuveau (prabotulinumtoxinA) last?
              The amount of time that the effects of Jeuveau (prabotulinumtoxinA) last varies from person to person. For most people, the effects of Jeuveau (prabotulinumtoxinA) last for a few months. In one study, around 15-25% of people had no lines or mild lines at about 5 months after getting Jeuveau (prabotulinumtoxinA). In general, you shouldn't get Jeuveau (prabotulinumtoxinA) more than once every 3 months.
              Where can Jeuveau (prabotulinumtoxinA) be injected?
              Jeuveau (prabotulinumtoxinA) is injected into certain forehead muscles by a trained healthcare professional. Typically, a small dose of Jeuveau (prabotulinumtoxinA) (about 5 units) is injected into five different sites on the forehead.
              Is Jeuveau (prabotulinumtoxinA) a filler?
              No, Jeuveau (prabotulinumtoxinA) isn't a filler. Dermal fillers are injections that contain substances that help temporarily smooth wrinkles and add fullness to certain areas of the body. Jeuveau (prabotulinumtoxinA) works differently because it blocks nerve signals in your muscles to smooth wrinkles. Talk with your dermatologist about which option would work best for your skincare goals.
              How many units of Jeuveau (prabotulinumtoxinA) do I need for my forehead?
              In general, a total dose of 20 units of Jeuveau (prabotulinumtoxinA) is split up and injected into muscles at five different areas on the forehead. Because of serious risks, Jeuveau (prabotulinumtoxinA) should only be injected by a trained healthcare professional (HCP). Your HCP might change your dose until they find the dose that works best for you.
              Can Jeuveau (prabotulinumtoxinA) cause headaches?
              It's possible for some people to experience a headache after using Jeuveau (prabotulinumtoxinA). In clinical studies, 12% of people who took Jeuveau (prabotulinumtoxinA) reported headache as a side effect. However, people who got a placebo injection (no medication) reported headache as a side effect too. Contact your HCP if your headache is severe or isn't going away after taking pain-relieving medication.
              What's the difference between Jeuveau (prabotulinumtoxinA) and Botox?
              Both Jeuveau (prabotulinumtoxinA) and Botox (onabotulinumtoxinA) are toxins made from bacteria (Clostridium botulinum). One main difference is what they're FDA-approved to treat. Both Jeuveau and Botox Cosmetic can ease frown lines. But Botox Cosmetic can also improve the looks of forehead lines and crow's feet. In addition, there's a non-cosmetic version of Botox that's approved to treat many medical conditions, including muscle spasms and overactive bladder. Talk with your HCP if you've questions about Jeuveau and Botox.
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              What are the risks and warnings for Jeuveau (prabotulinumtoxinA)?

              Jeuveau (prabotulinumtoxinA) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Spread of toxin effects

              Botulinum toxin medications, such as Jeuveau (prabotulinumtoxinA), can spread to other body areas outside of the injection site and cause toxic effects, occurring hours to weeks after receiving the medication. This can cause serious side effects, such as unexplained muscle weakness, drooping eyelids, blurred or double vision, breathing or swallowing difficulty, slurred speech or trouble speaking, or the need to urinate more frequently. If you notice any of these side effects, seek medical help right away.

              risk-warning

              Severe allergic reactions

              In some rare cases, medications like Jeuveau (prabotulinumtoxinA) can cause life-threatening allergic reactions. If you experience swelling in your face or throat, hives, or trouble breathing, get medical attention immediately. Your HCP might ask you to stop using Jeuveau (prabotulinumtoxinA) and other similar medications if you have a serious allergic reaction.

              risk-warning

              Difficulty swallowing or breathing

              • Risk factors: History of swallowing or breathing problems | Myasthenia gravis | Lambert-Eaton syndrome | Current muscle-nerve conditions

                Medications similar to Jeuveau (prabotulinumtoxinA) have caused life-threatening problems with swallowing or breathing by weakening muscles involved in these activities. This can occur hours to weeks after receiving the medication, and the effects can last for many months. Your risk is higher if you have certain conditions affecting your muscles or nerves, or if you're receiving Jeuveau (prabotulinumtoxinA) in areas of the body other than what it was approved for. If you have a history of swallowing or breathing problems, let your HCP know before starting Jeuveau (prabotulinumtoxinA) treatment. Seek medical help right away if you notice any trouble swallowing or breathing.

                risk-warning

                Worsening of certain conditions

                • Risk factors: History of certain muscle-nerve conditions | History of heart problems | Inflammation at injection site

                  In people with certain medical conditions, Jeuveau (prabotulinumtoxinA) can make symptoms worse and cause serious side effects. Heart problems, including arrhythmia (irregular heartbeat) and heart attack, have been reported after people received botulinum toxin medications like Jeuveau (prabotulinumtoxinA). People with certain muscle-nerve conditions may have a higher risk of serious side effects from Jeuveau (prabotulinumtoxinA), including muscle weakness in the body, double vision, drooping eyelids, and trouble speaking, eating, drinking, or breathing. If you experience any of these side effects, seek medical help immediately.

                  Make sure to discuss your full medical history with your HCP before using Jeuveau (prabotulinumtoxinA). You should also let your HCP know if you have any redness or swelling at the areas on your body where you'll be getting the injections, or if you're currently experiencing drooping eyelids or muscle weakness.

                  risk-warning

                  Dry eyes

                  Some people experience dry eyes with the use of botulinum toxin medications like Jeuveau (prabotulinumtoxinA) for frown lines. If symptoms of dry eye (e.g., eye irritation, sensitivity to light, vision changes) don't go away, let your HCP know. You might need to see an eye specialist.

                  dosage

                  Jeuveau (prabotulinumtoxinA) dosage forms

                  Typical dosing for Jeuveau (prabotulinumtoxinA)

                  Jeuveau (prabotulinumtoxinA) is only available as an intramuscular (IM) injection that's administered by a healthcare professional (HCP). The dose of Jeuveau (prabotulinumtoxinA) is measured in units.

                  • Adults: Typically, your HCP will inject 4 units of Jeuveau (prabotulinumtoxinA) into each of the 5 sites on your forehead, for a maximum of 20 units total per treatment. You can receive a treatment no more often than once every 3 months.

                  contraindications-icon

                  Jeuveau (prabotulinumtoxinA) contraindications

                  Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Jeuveau (prabotulinumtoxinA) will not be safe for you to take.

                  • Infection at injection site

                  alternatives

                  What are alternatives to Jeuveau (prabotulinumtoxinA)?

                  There are a number of medications that your doctor can prescribe in place of Jeuveau (prabotulinumtoxinA). Compare a few possible alternatives below.
                  Jeuveau (prabotulinumtoxinA)
                  Used for:

                  • Temporary improvement in moderate-to-severe frown lines (glabellar lines) in adults

                  View Prices
                  Botox Cosmetic (onabotulinumtoxinA)
                  Used for:

                  • Temporarily improves the appearance of frown lines, forehead lines, and crow's feet lines in adults

                  $367.81 Lowest GoodRx priceView Prices
                  Dysport (abobotulinumtoxinA)
                  Used for:

                  • Neck spasms (cervical dystonia) in adults

                  • Frown lines in adults under 65 years old

                  • Muscle spasms in upper and lower limbs in adults and children age 2 years and older

                  $540.24 Lowest GoodRx priceView Prices

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                  References

                  Best studies we found

                  Evolus, Inc. (2023). Jeuveau- prabotulinum toxin type a powder [package insert]. DailyMed.

                  Gadarowski, M. B., et al. (2021). PrabotulinumtoxinA-xvfs for the treatment of moderate-to-severe glabellar lines. The Annals of Pharmacotherapy.

                  Lagueny, A., et al. (1996). Mécanisme d'action, indication et résultats des traitements par la toxine botulinique [Mechanism of action, clinical indication and results of treatment of botulinum toxin]. Neurophysiologie Clinique. 

                  View All References (2)

                  Lorenc, Z. P., et al. (2021). The second of two one-year, multicenter, open-label, repeat-dose, phase II safety studies of prabotulinumtoxinA for the treatment of moderate to severe glabellar lines in adult patients. Aesthetic Surgery Journal.

                  Ogilvie, P., et al. (2022). PrabotulinumtoxinA for treatment of millennials with moderate to severe glabellar lines: Post hoc analyses of the phase III clinical study data. Dermatologic Surgery.

                  GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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