8 Nurtec ODT Interactions to Consider
Key takeaways:
Nurtec ODT (rimegepant) is a medication that treats and prevents migraines. You should avoid taking it with clarithromycin (Biaxin XL), ketoconazole, and ritonavir (Norvir). They can raise Nurtec ODT levels in the body and increase your risk of side effects. Amiodarone, cyclosporine, and grapefruit juice have a similar interaction, and shouldn’t be combined with Nurtec ODT either.
Some medications and supplements, such as St. John’s wort, carbamazepine, and phenytoin, can make Nurtec ODT less effective. It’s best to avoid them or talk to your prescriber about a different migraine medication.
In some cases, it’s OK to take Nurtec ODT with an interacting medication. You’ll just need to separate each dose of Nurtec ODT by at least 48 hours. Your prescriber should let you know if this applies to you.
Access savings on related medications
Table of contents
If you’re dealing with chronic migraines, medications such as Nurtec ODT (rimegepant) can be life-changing. You can take Nurtec ODT every other day to prevent migraines, or as needed to treat them when they occur. But no matter how you take it, Nurtec ODT has drug interactions that could impact its effectiveness or increase side effects.
Here, we’ll review eight Nurtec ODT interactions you should know about. Other interactions are possible, so be sure to review your medication list with your healthcare team.
1. Certain antibiotics, such as clarithromycin
Certain antibiotics block an enzyme that breaks down Nurtec ODT in the body. This interaction can raise Nurtec ODT levels and increase your risk for side effects, such as nausea and stomach pain. Some antibiotics have a larger effect on Nurtec ODT levels than others.
Clarithromycin (Biaxin XL) is one antibiotic that can significantly increase Nurtec ODT levels. To be safe, it’s best to avoid taking clarithromycin and Nurtec ODT together.
Other antibiotics, such as erythromycin and ciprofloxacin, have a smaller effect on Nurtec ODT levels. It’s OK to take Nurtec ODT with these antibiotics. But if you do, it’s recommended you wait at least 48 hours between each dose of Nurtec ODT. This spacing helps prevent your medication levels from going too high.
If you need an antibiotic, tell your prescriber you’re taking Nurtec ODT. They may choose a treatment option that doesn’t interact with it. Or they may have you avoid or limit how often you take Nurtec ODT until you’ve finished your antibiotic.
2. Certain antifungals, such as ketoconazole
Certain antifungal medications can also interact with Nurtec ODT. Similar to antibiotics, they can raise the levels of Nurtec ODT in the body. And some antifungals are riskier than others.
Itraconazole (Sporanox) and ketoconazole have a stronger effect on Nurtec ODT levels. It’s best to avoid combining them with the migraine medication.
Fluconazole (Diflucan) and voriconazole (Vfend) don’t raise Nurtec ODT levels as much. So it’s fine to take them together as long as you wait 48 hours between each dose of Nurtec ODT.
If you need treatment for a fungal infection, let your prescriber know you’re taking Nurtec ODT. They can let you know if you need to adjust your doses due to an interaction.
Good to know: Topical antifungals, such as Nizoral A-D shampoo or ketoconazole cream, don’t interact with Nurtec ODT. They don’t absorb into the body enough to cause an interaction. So it’s fine to combine these medications.
3. Ritonavir
Ritonavir (Norvir) is an antiviral medication that interacts with many medications. It’s part of some combination HIV medications, such as Kaletra (lopinavir / ritonavir). It’s also an ingredient in Paxlovid (nirmatrelvir / ritonavir), which treats COVID-19.
Ritonavir has a strong blocking effect on the enzyme that breaks down Nurtec ODT. As a result, it can raise Nurtec ODT levels in the body and lead to side effects. It’s best to avoid taking these medications together.
For a short-term medication like Paxlovid, your prescriber may have you stop taking Nurtec ODT temporarily until your treatment is finished. But if you need to take a medication that contains ritonavir long term, you’ll likely need to stop taking Nurtec ODT. Your prescriber can recommend a safer option to prevent or treat your migraines.
4. Calcium channel blockers, such as diltiazem
Diltiazem (Cardizem) and verapamil (Verelan) are calcium channel blockers that can interact with Nurtec ODT. As with the medications listed above, they can raise Nurtec ODT levels in the body.
To help offset this risk, it’s recommended that you space Nurtec ODT doses at least 48 hours apart if you take these medications together. So you’ll likely need a different medication to prevent migraines if you take one of these calcium channel blockers.
5. Grapefruit juice
Grapefruit juice can interact with several medications, and Nurtec ODT is one of them. Like the previous medications, grapefruit and grapefruit juice can block an enzyme in your body, which raises Nurtec ODT levels.
It’s best to avoid consuming grapefruit and grapefruit juice often or in large amounts while you’re taking Nurtec ODT. If grapefruit is a regular part of your diet, talk to your prescriber about a different migraine medication.
6. Some anti-seizure medications, such as carbamazepine
Carbamazepine (Tegretol), phenytoin (Dilantin), and phenobarbital are anti-seizure medications. These medications have the opposite effect of the previous interactions. They increase the activity of the enzyme that breaks down Nurtec ODT. So these medications can lower Nurtec ODT levels and make it less effective.
It’s best to avoid taking Nurtec ODT with these medications. Your prescriber will likely recommend a different migraine medication for you.
7. St. John’s wort
St. John’s wort is an herbal supplement. Since it’s sold over the counter, it’s easy to forget that St. John’s wort can interact with other medications. But it can lower Nurtec ODT levels and make the medication less effective.
It’s best to avoid St. John’s wort if you’re taking Nurtec ODT. Talk to your prescriber or pharmacist about a safer option. And don’t forget to check with your pharmacist about interactions before adding any other supplements to your routine.
8. Amiodarone and cyclosporine
Amiodarone (Nexterone, Pacerone) and cyclosporine (Gengraf, Neoral) can raise Nurtec ODT levels if they’re combined. They increase how much Nurtec ODT your body absorbs when you take it.
It’s OK to take these medications together, but you should wait at least 48 hours between each dose of Nurtec ODT. And you may need a different medication to prevent migraines if you’re taking amiodarone or cyclosporine.
Can you take Nurtec ODT with Tylenol or NSAIDs?
Yes. But you should talk to your prescriber about it first.
There are no interactions between Nurtec ODT and over-the-counter pain relievers, such as Tylenol (acetaminophen). It’s also safe to take nonsteroidal anti-inflammatory drugs (NSAIDs), such as naproxen (Aleve), with Nurtec ODT.
But in most cases, it’s best to try one medication and see if it works before adding another. So you shouldn’t take an OTC pain reliever with Nurtec ODT every time you get a migraine unless your prescriber tells you to. Taking OTC pain relievers too often can cause medication overuse headaches, also known as rebound headaches.
If you take Nurtec ODT to prevent migraines, you can safely take acetaminophen or NSAIDs as needed in most cases.
Can you take Nurtec ODT with other migraine medications?
Possibly, if your prescriber recommends it.
If you take Nurtec ODT regularly to prevent migraines, it’s safe to take a different type of medication if a migraine occurs. Common treatments include NSAIDs and triptans.
If Nurtec ODT is your rescue treatment when you get a migraine, you may take a different medication to help prevent them. Common options include topiramate (Topamax, Qudexy XR) and propranolol.
Nurtec ODT is a calcitonin gene-related peptide (CGRP) antagonist. In most cases, you shouldn’t take it with other oral CGRP antagonists (“gepants”), such as Ubrelvy (ubrogepant). There’s some evidence that taking one gepant for migraine prevention and a different gepant for migraine treatment may be OK. But you shouldn’t do this unless your prescriber tells you to.
Injectable CGRP antagonists are monoclonal antibodies that block CGRP in a different way than the oral gepants. Limited research suggests that combining these two types of medications may be effective, but more studies are underway to ensure it’s safe.
Everyone responds to migraine medications differently. So be sure to let your prescriber know if Nurtec ODT isn’t effective for you. They can add other medications or change your treatment if needed to improve your symptoms.
The bottom line
Nurtec ODT (rimegepant) is a medication that helps prevent or treat migraines. Serious Nurtec ODT interactions include clarithromycin (Biaxin XL), ketoconazole, and ritonavir (Norvir). These medications can raise Nurtec ODT levels in the body and should be avoided. You shouldn’t take Nurtec ODT with grapefruit juice, amiodarone (Nexterone, Pacerone), or cyclosporine (Gengraf, Neoral) for the same reason.
St. John’s wort and some anti-seizure medications can make Nurtec ODT less effective. You should avoid taking them together.
In some cases, you can still take Nurtec ODT with a medication it interacts with. You’ll just need to separate each dose of Nurtec ODT by at least 48 hours. Your prescriber should let you know if you need to do this based on your medication list. But be sure to let them know you’re taking Nurtec ODT if you’re starting a new medication.
Why trust our experts?
References
Aoh, Y., et al. (2024). Update on gepants for the treatment of chronic migraine. Journal of the Chinese Medical Association.
Carreras, E., et al. (2019). Table 31.1: CYP3A4 substrates, inhibitors and inducers commonly used in HSCT (non-limitative list). The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies.
Dixon, D. M., et al. (1996). Antifungal agents. Medical Microbiology.
DrugBank. (n.d.). Cytochrome P-450 CYP3A4 inducers (strong).
Loos, N. H. C., et al. (2022). The mechanism-based inactivation of CYP3A4 by Ritonavir: What mechanism? International Journal of Molecular Sciences.
Pfizer Laboratories div Pfizer Inc. (2023). Nurtec ODT [package insert].
Shah, T., et al. (2023). Calcitonin gene relating peptide inhibitors in combination for migraine treatment: A mini-review. Frontiers in Pain Research.
U.S. Food and Drug Administration. (2021). Grapefruit juice and some drugs don't mix.
Was this page helpful?
Related Articles
Browse medications
View AllResearch prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.