Medications for nasal congestion are used to treat a stuffy nose caused by allergies and upper respiratory infections, such as the common cold and sinus infections. These work by reducing nasal inflammation and shrinking swollen nasal tissues. Common classes include intranasal corticosteroids and alpha-1 agonists. Intranasal corticosteroids, such as fluticasone propionate (Flonase) and mometasone (Nasonex), are available as nasal sprays. Alpha-1 agonists, such as pseudoephedrine (Sudafed) and oxymetazoline (Afrin), come in oral forms and as nasal sprays. These options provide different ways to help relieve your nasal congestion effectively.