Desonide (DesOwen, DesRx, Verdeso) and triamcinolone (Triderm, Triasil, Tritocin, Kenalog) are both topical corticosteroids used to treat skin conditions like eczema. They work by reducing inflammation and calming the immune response. However, they differ in potency and usage. Desonide is a low-potency steroid available in forms like foam, gel, and ointment, and is safe for children as young as 3 months when using foam and gel. Triamcinolone is a medium-strength steroid available in cream, ointment, lotion, and spray, and is used for a wider range of inflammatory skin conditions, including psoriasis. Desonide is typically applied 2 to 4 times daily for up to 2 weeks (or 4 weeks for foam and gel), while triamcinolone's application frequency varies by formulation, ranging from 2 to 4 times daily. Both medications are available by prescription only and are available as a lower-cost generics. Common side effects for both include skin irritation and dryness, but triamcinolone may also cause excessive hair growth and acne-like bumps. Both medications should be used for short-term treatment to avoid side effects like skin thinning and hormonal changes.