Key takeaways
Clobetasol (Clobex, Olux) and tacrolimus (Protopic) are both topical medications used to treat skin conditions, but they belong to different medication classes. Clobetasol is a corticosteroid used for conditions like psoriasis and eczema, while tacrolimus is an immunosuppressant specifically approved for moderate-to-severe eczema. Clobetasol is a super potent steroid available in various forms like cream, shampoo, and spray, and is typically used for up to 2 weeks (4 weeks for shampoo). Tacrolimus, on the other hand, is a non-steroid ointment available in two strengths and can be used for up to 6 weeks or longer under a prescriber's guidance. Clobetasol is available as a lower-cost generic and is not recommended for use on the face, armpits, or groin, whereas tacrolimus can be applied to these areas. Common side effects of clobetasol include burning and skin irritation, while tacrolimus may cause burning, itching, and flu-like symptoms. Clobetasol can lead to skin thinning and high blood sugar if used long-term, while tacrolimus carries a risk of skin infections and increased sensitivity to sunlight.
