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Compare Fludrocortisone vs. Proamatine

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Fludrocortisone (generic, brand name Florinef no longer available) and midodrine (generic, brand name Proamatine no longer available) are both prescription medications, but they treat different conditions and belong to different drug classes. Fludrocortisone is a corticosteroid used to treat Addison's disease and congenital adrenal hyperplasia by maintaining the balance of sodium, potassium, and water in your body. It is typically taken once daily and can cause side effects like high blood pressure and swelling. On the other hand, midodrine is an alpha-1 adrenergic receptor agonist used to treat orthostatic hypotension by tightening blood vessels to raise blood pressure. You need to take midodrine three times a day while upright, as it can dangerously raise blood pressure if taken while lying down. Unlike fludrocortisone, midodrine does not cause weight gain but can cause tingling sensations and goosebumps. Both medications are available in generic forms, making them more affordable options.

  • Fludrocortisone
    Midodrine
  • Fludrocortisone
    Midodrine

  • Summary of Fludrocortisone vs. Proamatine

    Summary for Corticosteroid
    Prescription only

    Fludrocortisone acetate is a corticosteroid. It's used to treat conditions where the body doesn't make enough of certain hormones, such as Addison's disease, in adults. Fludrocortisone is taken by mouth, typically once daily. Some side effects of this medication include high blood pressure and swelling from fluids. If you need to stop fludrocortisone, your provider will help lower your dose slowly over time to help avoid withdrawal symptoms. It's available as a lower-cost generic tablet.

    Summary for Alpha-1 adrenergic receptor agonist
    Prescription only

    Midodrine is used to treat symptoms of orthostatic hypotension (low blood pressure that happens when there's a change from a lying down or sitting position to a standing position). It belongs to a drug class that works by squeezing your blood vessels in order to raise your blood pressure. You should only take midodrine while you're upright because it can raise your blood pressure to dangerous levels if you take it while lying down. Midodrine can cause side effects like tingling or pricking feeling and goosebumps. Midodrine is available as a generic; there's no brand-name version of this medication.

  • Indications of Fludrocortisone vs. Proamatine

    Indications for
    •Addison's disease (adrenal insufficiency)
    •Congenital adrenal hyperplasia (a genetic condition that affects hormone production)
    Indications for
    •Symptomatic orthostatic hypotension

  • Pros and Cons of Fludrocortisone vs. Proamatine

    Pros and Const for Corticosteroid
    Pros
    •A first-choice treatment option for primary adrenal insufficiency
    •Available in a lower-cost generic form
    •Usually only taken once per day
    Cons
    •Need to taper dose before stopping completely
    •Can cause weight gain
    •Not FDA-approved for use in children
    Pros and Const for Alpha-1 adrenergic receptor agonist
    Pros
    •Older adults don't need to have their dose adjusted.
    •Raises blood pressure within an hour after taking
    •Available as a lower-cost generic
    Cons
    •Must take the medication while upright
    •Has to be taken multiple times a day
    •Not studied in children

  • Common Side Effects of Fludrocortisone vs. Proamatine

    Common Side Effects for
    •Swelling from fluid buildup in the body
    •High blood pressure
    Common Side Effects for
    •Tingling or pricking feeling (18%)
    •Goosebumps (13%)
    •Painful urination (13%)
    •Itchy skin (12%)
    •High blood pressure when lying down (7%)
    •Chills (5%)
    •Pain (5%)
    •Rash (2%)

  • Warnings of Fludrocortisone vs. Proamatine

    Common Side Effects for
    •Higher blood pressure and swelling
    •Weakening of bones
    •Poor adrenal gland function
    •Greater risk of infections
    •Eye problems
    •Mood and behavior changes
    •Stomach problems
    Common Side Effects for
    •Significant rise in blood pressure when lying down
    •Slow heart rate
    •Taking midodrine while having other health problems

  • Prices with our coupons for Fludrocortisone vs. Proamatine

    Learn more about Fludrocortisone
    Learn more about Midodrine

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