Opioid-sudafed combinations are used to treat cough, nasal congestion, and sinus pressure. These medications work by combining an opioid, which helps to reduce coughing, with pseudoephedrine, a decongestant that relieves nasal and sinus congestion. These combinations are typically available in oral forms, such as tablets or liquid solutions. Examples include hydrocodone/pseudoephedrine (Rezira) and codeine/pseudoephedrine (Nucofed). You can choose the form that best fits your needs.