Ketoconazole cream and Oravig (miconazole) are both antifungal medications used to treat fungal infections, but they differ in their specific uses and forms. Ketoconazole cream is applied topically to treat skin infections like ringworm, jock itch, athlete's foot, and seborrheic dermatitis, while Oravig (miconazole) is a buccal tablet used for oral thrush in the mouth and throat. Ketoconazole cream is applied directly to the skin once or twice daily, depending on the condition, and is available as a lower-cost generic. In contrast, Oravig (miconazole) is a prescription-only tablet that dissolves in the mouth over six hours and does not have a generic version. Common side effects of ketoconazole cream include itching and skin irritation, whereas Oravig (miconazole) can cause mouth discomfort, diarrhea, and headaches. Additionally, ketoconazole cream is not known to cause liver damage when used topically, unlike its oral form, while Oravig (miconazole) should be used with caution if you have a milk protein allergy.