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Compare Nystop vs. Clotrimazole

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Nystatin (Nystop, Nyamyc, Klayesta) and clotrimazole (Lotrimin AF) are both antifungal medications, but they have some key differences. Nystatin is available by prescription only and is used to treat yeast infections on the skin. It comes in various forms like cream, ointment, and powder, and is safe for all ages, including babies. On the other hand, clotrimazole is available over-the-counter and treats a wider range of fungal infections, such as athlete's foot, jock itch, and ringworm. Clotrimazole is suitable for adults and children over 2 years old. While both medications are generally well-tolerated, nystatin is specifically for yeast infections, whereas clotrimazole can treat multiple types of fungal infections. Additionally, clotrimazole might take up to a month to fully treat certain infections, whereas nystatin can start working within a few days.

drug combination

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  • Nystatin topical
    Clotrimazole (Lotrimin AF)
  • Nystatin topical
    Clotrimazole (Lotrimin AF)

  • Summary of Nystop vs. Clotrimazole

    Summary for Antifungal
    Prescription only

    Nystatin topical is a medication that's used on the skin to treat certain fungal skin infections (most commonly yeast infections). It's safe to use in people of all ages, including babies for diaper rash. Nystatin topical comes in different formulations: cream, ointment, and powder. It's available by prescription only and can't be purchased over the counter. Rarely, some people experience itching and burning where they applied the medication. But most people experience few to no side effects while using nystatin topical as directed.

    Summary for Antifungal

    Clotrimazole (Lotrimin AF) is an over-the-counter (OTC) antifungal cream that's applied to the skin to treat certain infections, such as ringworm and athlete's foot. Sometimes, a provider might also recommend this medication for diaper rash. Clotrimazole (Lotrimin AF) is for adults and children 2 years and older, unless otherwise directed by a provider. Most people experience few to no side effects while using clotrimazole (Lotrimin AF), though mild skin irritations have been reported.

  • Indications of Nystop vs. Clotrimazole

    Indications for
    •Treatment of fungal skin infections (yeast infection)
    Indications for

    Treatment and symptom relief (e.g., itching, irritation, redness) of the following fungal skin infections:

    •Athlete’s foot
    •Jock itch
    •Ringworm

  • Pros and Cons of Nystop vs. Clotrimazole

    Pros and Const for Antifungal
    Pros
    •Available as a lower-cost generic medication
    •Many formulations to choose from, such as ointment, cream, and powder
    •Generally well-tolerated
    •Safe to use for newborns
    Cons
    •Applied onto skin multiple times a day
    •Only treats some fungal skin infections, not bacterial or viral infections
    •Might not work as well as antifungal medications that are taken by mouth
    •Not clear whether it's safe to use during pregnancy or while breastfeeding
    Pros and Const for Antifungal
    Pros
    •Available as a generic, over-the-counter medication
    •Side effects are typically minor or mild
    •Can treat multiple fungal infections, including athlete's foot, ringworm, and jock itch
    Cons
    •Need to apply twice daily
    •Can take up to a month to treat athlete's foot
    •Need to speak with provider before using it on children under 2 years old

  • Common Side Effects of Nystop vs. Clotrimazole

    Common Side Effects for
    •Burning
    •Itching
    •Rash
    •Eczema (dry, bumpy skin)
    •Pain when applying the medication onto the skin
    Common Side Effects for
    •Skin irritations (e.g., itching, redness)

  • Warnings of Nystop vs. Clotrimazole

    Common Side Effects for
    •Allergic reaction
    •Use only on your skin
    Common Side Effects for
    •Use only on your skin

  • Prices with our coupons for Nystop vs. Clotrimazole

    Learn more about Nystatin topical
    Learn more about Clotrimazole

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